Visual Outcome Evaluation and Genetic Analysis: Shanghai High Myopia Study

What this Trial Is About

This research aims to evaluate the long-term visual outcomes after cataract surgery in patients with high myopia compared to those with age-related cataract and ametropic cataract. It focuses on understanding the differences in clinical features and prognosis among these groups. Additionally, the study investigates genetic and environmental factors that may contribute to the development and progression of high myopic cataract using a large-scale clinical database. Participants are grouped into three categories: high myopic cataract, age-related cataract, and ametropic cataract patients. Researchers will analyze genetic variations by sequencing selected genes related to cataract pathogenesis, vitreoretinopathy, and postoperative complications. The study uses comprehensive clinical data and biological samples to explore single nucleotide polymorphisms and their correlation with clinical characteristics. During the study, participants will undergo ophthalmic examinations and follow-up evaluations for up to five years after surgery to assess visual outcomes. Genetic diversity will be analyzed within six months post-surgery. The study monitors clinical phenotypes, visual results, and genetic markers to better understand the disease and improve prevention and prognosis. Participant involvement includes clinical assessments and sample collection, and the study duration spans from surgery through long-term follow-up.

Shanghai High Myopia Study