Actively Recruiting
A Single-cell Approach to Identify Biomarkers of Pulmonary Toxicity for Immune Checkpoint Blockade
Led by Universitaire Ziekenhuizen KU Leuven · Updated on 2024-07-01
60
Participants Needed
1
Research Sites
260 weeks
Total Duration
On this page
Sponsors
U
Universitaire Ziekenhuizen KU Leuven
Lead Sponsor
K
KU Leuven
Collaborating Sponsor
AI-Summary
What this Trial Is About
The main goal of this prospective non-interventional exploratory monocentric study is to characterize the immune cell composition of bronchoalveolar lavage (BAL) fluid from cancer patients experiencing cancer therapy-induced pneumonitis on a single-cell scale. These mechanistic insights can directly lead to putative diagnostic biomarkers and therapeutic targets. A second highly clinically relevant hypothesis is that single-cell profiling of blood samples will reveal circulating biomarkers of ICB toxicity, making non-invasive diagnosis feasible.
CONDITIONS
Official Title
A Single-cell Approach to Identify Biomarkers of Pulmonary Toxicity for Immune Checkpoint Blockade
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 years or older
- Receiving or have received cancer treatment according to guidelines
- Undergoing bronchoscopy with bronchoalveolar lavage for possible cancer treatment-induced pneumonitis
- Not currently participating in other clinical trials
- Signed informed consent form
You will not qualify if you...
- Samples collected are of poor quality or not suitable for single-cell analysis, as determined by laboratory specialists
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Universitaire Ziekenhuizen Leuven
Leuven, Flemish Brabant, Belgium, 3000
Actively Recruiting
Research Team
E
Els Wauters, MD, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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