One slide fits all: the versatility of slide tracheoplasty with cardiopulmonary bypass support for airway reconstruction in children.
Peter B Manning, Michael J Rutter, Asher Lisec...
https://pubmed.ncbi.nlm.nih.gov/21055774Actively Recruiting
Phase Not Applicable
All Genders
ID06917222
Slide Tracheoplasty Versus Tracheal Resection Anastomosis in Acquired Tracheal Stenosis
Led by Mansoura University Hospital ยท Updated on 2025-09-25
30
Participants Needed
1
Research Sites
8 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are comparing two surgical methods, slide tracheoplasty and tracheal resection anastomosis, to treat patients with acquired tracheal stenosis, a condition that narrows the airway and can cause breathing difficulties. The study aims to evaluate which procedure offers better clinical outcomes for patients with this condition, including those with subglottic stenosis. This randomized, single-blind trial is sponsored by Mansoura University Hospital. The study involves two groups: one receiving slide tracheoplasty and the other undergoing tracheal resection anastomosis. Both procedures are surgical techniques intended to manage tracheal stenosis. Patients will be randomly assigned to one of these two experimental treatment groups. The trial does not specify additional treatment details or dosing as these are procedural interventions. Participants will be monitored for up to six months, with the primary outcome being the success rate of the procedure assessed between three to six months after surgery. Secondary outcomes include complication rates, duration of hospital stay, and time to decannulation, all measured up to three months post-treatment. This monitoring will help determine the effectiveness and safety of each surgical method for airway obstruction caused by tracheal stenosis.
CONDITIONS
Brief Title
Slide Tracheoplasty Versus Tracheal Resection Anastomosis in Acquired Tracheal Stenosis
Who Can Participate
All Genders
Eligibility Criteria
You may qualify if you...
- All patients with grade III or IV acquired tracheal stenosis regardless of age or sex
- Patients with symptomatic high grade II acquired laryngotracheal stenosis after failure of endoscopic treatments
- Clinical need for surgery due to airway obstruction symptoms
- Suitable candidates for surgical intervention
You will not qualify if you...
- Congenital tracheal stenosis
- Malignant tracheal stenosis
- Severe other health conditions that prevent surgery
- Patients who do not agree to sign consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Surgery and Immediate Post-operative Care
Duration - Up to 3 months
Participants undergo either slide tracheoplasty or tracheal resection anastomosis to manage tracheal stenosis followed by immediate post-operative care.
Hospital stay and follow-up visits during recovery period
Post-operative Follow-up
Duration - 3 to 6 months
Participants are monitored for procedure success, complications, and recovery including time to decannulation after surgery.
Regular follow-up visits over 3 to 6 months after surgery
Trial Site Locations
Total: 1 location
1
Eslam Hamed
Al Mansurah, Egypt
Actively Recruiting
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Research Team
E
Eslam Hamed Abdou, Assistant lecturer
A
Ahmed Elsobki, Associated professor
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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Published Research Related To This Trial
Tracheal and bronchial stenoses and other obstructive conditions.
Claudia Schweiger, Aliza P Cohen, Michael J Rutter
https://pubmed.ncbi.nlm.nih.gov/28066618Diagnosis and management of laryngotracheal stenosis.
Matthew M Smith, Robin T Cotton
https://pubmed.ncbi.nlm.nih.gov/29969925Slide tracheoplasty for congenital funnel-shaped tracheal stenosis.
V Tsang, A Murday, C Gillbe...
https://pubmed.ncbi.nlm.nih.gov/2818051Systematic Review of Slide Tracheoplasty Outcomes.
Habib G Zalzal, Hengameh K Behzadpour, James Leonard...
https://pubmed.ncbi.nlm.nih.gov/35723210Tracheal stenosis.
J P Bocage, R Caccavale, R Lewis...
https://pubmed.ncbi.nlm.nih.gov/2395535Cervical slide tracheoplasty.
Alessandro de Alarcon, Michael J Rutter
https://pubmed.ncbi.nlm.nih.gov/22986713Endoscopic treatment of tracheal stenosis.
Lutz Freitag, Kaid Darwiche
https://pubmed.ncbi.nlm.nih.gov/24295657Surgical treatment of postintubation tracheal injuries.
H C Grillo
https://pubmed.ncbi.nlm.nih.gov/502569Acquired tracheal stenosis: Cervical slide tracheoplasty.
Carol Li, Michael J Rutter
https://pubmed.ncbi.nlm.nih.gov/34172213