Identification of the Sources and Mechanisms of Energy Compensation in Humans

What this Trial Is About

This research aims to understand how moderate to high intensity exercise affects energy expenditure, energy intake, and food preferences in healthy young adult males aged 18 to 40. The study explores the complex balance between energy used and energy consumed, focusing on whether exercise influences basal metabolism and macronutrient choices. Researchers will also examine how body composition impacts the body's compensation mechanisms related to energy balance. Participants will undergo body composition testing including measurements of weight, height, fat mass, bone mass, lean mass, and 3D body parameters after fasting for at least 10 hours. They will wear continuous glucose monitors, motion monitoring devices, and ambient temperature sensors during the 14-day study. The study includes two main trials: a control day with no exercise and an exercise day involving 30 minutes of cycling at moderate to high intensity. During both days, energy intake will be measured through controlled meals, and metabolic rates will be assessed hourly using indirect calorimetry. Blood samples, sweat, urine, and feces will be collected at specific times for metabolic and hormone analysis. Participants will visit the lab for body composition scans and testing, followed by controlled meal tests while monitoring metabolic rates and subjective hunger through questionnaires. Blood glucose levels will be continuously monitored for four days, and physical activity and environmental temperature data will be collected for the full 14-day period. The main outcomes measured include macronutrient preferences, energy intake, and basal metabolic rate during controlled meal times and exercise sessions. Safety measures such as blood pressure and body temperature are also recorded to assess overall metabolic responses throughout the study.

Sources and Mechanisms of Energy Compensation