The Role of Molecular Diagnostics in the Management of Indeterminate Thyroid Nodules.
Joanna Klubo-Gwiezdzinska, Leonard Wartofsky
https://pubmed.ncbi.nlm.nih.gov/30032182Actively Recruiting
Age: 6Months - 98Years
All Genders
ID00001160
Studies on Thyroid Nodules and Thyroid Cancer
Led by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) · Updated on 2026-05-12
2500
Participants Needed
1
Research Sites
N/A
Total Duration
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AI-Summary
What this Trial Is About
Researchers are studying patients diagnosed with or suspected to have thyroid nodules or thyroid cancer to improve understanding of diagnosis and treatment methods. This observational study includes both adults and children and aims to assess current standard care alongside new techniques, including genetic research and evaluation of tumor markers. The study also examines the use of serum thyroglobulin measurements to detect tumor recurrence. Participants will undergo diagnostic imaging, fine needle aspiration biopsy, surgery, radioiodine scanning or therapy, and follow-up with tumor marker monitoring and imaging. Samples from benign nodules and cancerous tissue will be collected for research using microscopy, immunohistochemistry, proteomics, and molecular analysis. The study also evaluates the risks and benefits of radioiodine therapy and individualized treatment approaches. During the study, blood and urine samples will be collected in different thyroid function states for research purposes. Participants will receive evaluations of thyroid cancer and thyroid disorders as clinically indicated. The study involves routine clinical care assessments, including anatomical and functional imaging, tumor marker monitoring, and genetic studies. The overall goal is to gather data to improve diagnosis, therapy, and understanding of thyroid tumors and thyroid function effects on the body.
CONDITIONS
Brief Title
Studies on Tumors of the Thyroid
Who Can Participate
Age: 6Months - 98Years
All Genders
Eligibility Criteria
You may qualify if you...
- Male or female, adults or children 6 months or older
- Patients with known or suspected thyroid nodules and/or thyroid cancer
- At risk family members of patients with genetic susceptibility to thyroid cancer
You will not qualify if you...
- Serious medical conditions restricting diagnostic testing or therapy such as renal failure, congestive cardiac failure, or active non-thyroid cancer requiring intervention before thyroid cancer treatment
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
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2
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Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Diagnostic Evaluation
Duration - Varies based on clinical needs
Participants undergo diagnostic imaging, fine needle aspiration biopsy, and laboratory assessments to evaluate thyroid nodules or thyroid cancer as clinically indicated.
Visits occur as clinically indicated for imaging and biopsy assessments
Treatment and Monitoring
Duration - Varies depending on treatment and monitoring schedules
Participants who receive surgery, radioiodine scanning or therapy, and tumor marker monitoring are evaluated to assess treatment effects and risk/benefit ratio.
Visits occur as clinically indicated during treatment and monitoring phases
Long-term Monitoring
Duration - Long-term, based on clinical follow-up needs
Participants are followed with tumor marker monitoring and anatomical and functional imaging to observe the natural history and detect recurrence of thyroid tumors.
Follow-up visits occur as clinically indicated for ongoing monitoring
Trial Site Locations
Total: 1 location
1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892
Actively Recruiting
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Research Team
P
Padmasree Veeraraghavan, R.N.
J
Joanna Klubo-Gwiezdzinska, M.D.
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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Published Research Related To This Trial
Limited Utility of Circulating Cell-Free DNA Integrity as a Diagnostic Tool for Differentiating Between Malignant and Benign Thyroid Nodules With Indeterminate Cytology (Bethesda Category III).
Shilpa Thakur, Andrew Tobey, Brianna Daley...
https://pubmed.ncbi.nlm.nih.gov/31620364