Actively Recruiting
A Study of Biological, Genetic, and Constitutional Factors and Non-invasive Monitoring to Assess Personal Cancer Risks
Led by Fondazione del Piemonte per l'Oncologia · Updated on 2026-03-13
850
Participants Needed
1
Research Sites
204 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The PRO-ACTIVE study aims to develop a clinical-translational program in the field of cancer prevention in all its phases (primary, secondary, and tertiary) to intervene before the clinical and radiological manifestation of the disease. It starts with risk prediction and leads to early diagnosis of the disease or recurrence in the subclinical phase. The PRO-ACTIVE study includes the following activities: * WP1: Integrated DNA-RNA approach for the identification of hereditary markers of predisposition to tumors * WP2: Global biological and molecular analysis of the host and tumor for the prevention and monitoring of recurrences * WP3: Analysis of the immunological status for the diagnosis of primary prevention and relapses in correlation to genetic and environmental factors * WP4: Study of the tumor microenvironment for recurrence prediction
CONDITIONS
Official Title
A Study of Biological, Genetic, and Constitutional Factors and Non-invasive Monitoring to Assess Personal Cancer Risks
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age >18 years
- Patients with breast cancer, including those meeting AIOM criteria for BRCA testing and patients with lobular breast cancer
- Patients with radically resected colon cancer, including stage III colon cancer with vascular invasion
- Patients with ovarian carcinomas
- Patients with metastatic melanoma
- Patients with stage IIB and IIIA non-small cell lung cancer
You will not qualify if you...
- Age <18 years
- Unwillingness or inability to give informed consent
AI-Screening
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Trial Site Locations
Total: 1 location
1
Fondazione del Piemonte per l'Oncologia-IRCCS Candiolo
Candiolo, Turin, Italy, 10060
Actively Recruiting
Research Team
V
Vanesa Gregorc, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
5
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