Actively Recruiting

Age: 19Years +
All Genders
ID05856786

To Study the Effects of Refractive Surgery on Optical Coherence Tomography (OCT) Measurements in the Eye: A Pilot Study

Led by University of Nebraska · Updated on 2026-03-18

33

Participants Needed

1

Research Sites

N/A

Total Duration

On this page

AI-Summary

What this Trial Is About

Refractive surgeries such as Lasik are commonly used to correct focusing problems like myopia, or nearsightedness. Patients who undergo these surgeries often need monitoring for other eye conditions such as myopic maculopathy or glaucoma using optical coherence tomography (OCT). This research aims to study how refractive surgery might affect OCT measurements in the eye, as changes in the eye's refractive status could influence the test results, but this effect has not been well studied before. The study includes patients aged 19 years or older who are scheduled for refractive surgery. Each patient will have OCT scans performed before the surgery, one day after, and one week after the procedure. The study will analyze changes in macular thickness and other ocular parameters by comparing these measurements over time. Participants will undergo OCT scans at three time points: baseline before surgery, 1 day after surgery, and 1 week after surgery. Researchers will measure macular thickness as the primary outcome and also assess secondary outcomes such as choroidal thickness, visual acuity, central corneal thickness, anterior chamber depth, and keratometry. The study will monitor these eye parameters closely to understand any changes following refractive surgery.

CONDITIONS

Brief Title

To Study the Effects of Refractive Surgery on OCT Measurements in the Eye

Who Can Participate

Age: 19Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Patients undergoing refractive surgery
  • For patients undergoing bilateral eye surgery, the one with higher degree of ametropia will be included
  • Patients aged 19 years or older
Not Eligible

You will not qualify if you...

  • Astigmatism more than 3 Diopters
  • Visual acuity worse than 20/25
  • Patients with unstable visual fixation
  • Severe dry eye

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Surgery and Immediate Post-operative Care

Duration - 1 day

Participants undergo refractive surgery and receive immediate post-operative care.

1 visit (in-person)

Post-operative Follow-up

Duration - 1 week

Participants have follow-up visits to monitor changes in eye parameters after surgery using optical coherence tomography (OCT).

2 visits (1 day and 1 week after surgery, in-person)

Trial Site Locations

Total: 1 location

1

Unversity of Nebraska Medical Center

Omaha, Nebraska, United States, 68105

Actively Recruiting

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Research Team

P

Pukhraj P Rishi, MBBS

T

Tolulope A Fashina, MD

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

1

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Published Research Related To This Trial

Evaluation of the change in retinal thickness after femtosecond laser-assisted laser in situ keratomileusis and photorefractive keratectomy.

Cemal Ozsaygili, Orhan Altunel, Necati Duru

https://pubmed.ncbi.nlm.nih.gov/34231433

Evaluation of peripapillary - macular microvascularity and choroidal vascularity index after refractive surgery.

Gülay Yalçınkaya, Burçin Kepez Yıldız, İhsan Çakır...

https://pubmed.ncbi.nlm.nih.gov/34995787