Actively Recruiting
A Study to Evaluate Different Targeted Therapies for Patients With Rheumatoid Arthritis
Led by AbbVie · Updated on 2026-05-13
180
Participants Needed
71
Research Sites
123 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Rheumatoid Arthritis (RA) is a chronic inflammatory disease causing pain, stiffness, swelling and loss of joint function. This study will evaluate the efficacy and safety of targeted therapies through a series of substudies for the treatment of moderately to severely active Rheumatoid Arthritis (RA). This study currently includes 3 substudies evaluating different treatments in participants with RA. Substudy 1 will evaluate lutikizumab monotherapy (treatment given alone) compared to placebo (looks like the study treatment but contains no medicine). Substudy 2 will evaluate ravagalimab monotherapy compared to placebo and Substudy 3 will evaluate lutikizumab and ravagalimab combination therapy (treatments given together) compared to placebo. Approximately 180 participants who have failed 1 or 2 biologic/targeted synthetic disease-modifying antirheumatic drug (tsDMARD) therapies will be enrolled in the study at approximately 65 sites worldwide. There may be higher treatment burden for participants in this trial compared to their standard of care treatment without participating in this study. Participants will attend regular visits during the study at a hospital or clinic. The effect of the treatment will be checked by medical assessments, blood tests, checking for side effects and completing questionnaires.
CONDITIONS
Official Title
A Study to Evaluate Different Targeted Therapies for Patients With Rheumatoid Arthritis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Treated for 3 months or more with at least one biologic or targeted synthetic disease-modifying antirheumatic drug (b/tsDMARD) but still have active rheumatoid arthritis or stopped treatment due to intolerance or toxicity
- Used no more than two prior b/tsDMARD therapies
- Currently on a stable dose of methotrexate (MTX)
You will not qualify if you...
- Taking NSAIDs, acetaminophen, low-potency opioids, oral corticosteroids (up to 10 mg/day prednisone equivalent), or inhaled corticosteroids but not on stable doses for at least 1 week before baseline visit
- History of arthritis starting before age 17 or diagnosis of inflammatory joint disease other than rheumatoid arthritis
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 71 locations
1
Sun Valley Arthritis Center /ID# 278331
Peoria, Arizona, United States, 85381
Actively Recruiting
2
Private Practice - Dr. David S. Hallegua /ID# 277608
Beverly Hills, California, United States, 90211
Actively Recruiting
3
Advanced Clinical Research Center, LLC dba TriWest Research Associates /ID# 277826
Chula Vista, California, United States, 91910
Actively Recruiting
4
Newport Huntington Medical Group /ID# 272439
Huntington Beach, California, United States, 92648-5994
Actively Recruiting
5
Cohen Medical Centers /ID# 278341
Thousand Oaks, California, United States, 91360
Actively Recruiting
6
The Lundquist Institute /ID# 272481
Torrance, California, United States, 90502
Actively Recruiting
7
Inland Rheumatology & Osteoporosis Medical Group /ID# 272449
Upland, California, United States, 91786
Actively Recruiting
8
Tekton Research - Fort Collins - East Harmony Road /ID# 272472
Fort Collins, Colorado, United States, 80528
Actively Recruiting
9
Highlands Advanced Rheumatology And Arthritis Center - Avon Park /ID# 272298
Avon Park, Florida, United States, 33825
Actively Recruiting
10
Clinical Research Of West Florida - Phase I Unit /ID# 272428
Clearwater, Florida, United States, 33765
Actively Recruiting
11
Neoclinical Research - Hialeah /ID# 272070
Hialeah, Florida, United States, 33016
Actively Recruiting
12
South Florida Rheumatology /ID# 278339
Hollywood, Florida, United States, 33026
Actively Recruiting
13
Swati Shah, MD Rheumatology /ID# 273624
Jacksonville, Florida, United States, 32257
Actively Recruiting
14
Life Clinical Trials /ID# 272589
Margate, Florida, United States, 33063
Actively Recruiting
15
HMD Research LLC /ID# 272432
Orlando, Florida, United States, 32819
Actively Recruiting
16
Clinical Research Of West Florida - Tampa - North Howard Avenue /ID# 272755
Tampa, Florida, United States, 33606
Actively Recruiting
17
Northwestern Medicine - Northwestern Memorial Hospital /ID# 275422
Chicago, Illinois, United States, 60611
Actively Recruiting
18
Deerbrook Medical Associates /ID# 273439
Libertyville, Illinois, United States, 60048
Actively Recruiting
19
Advanced Quality Medical Research /ID# 277824
Orland Park, Illinois, United States, 60462
Actively Recruiting
20
Willow Rheumatology and Wellness, PLLC /ID# 272691
Willowbrook, Illinois, United States, 60527
Actively Recruiting
21
Accurate Clinical Research (SMO/Network/Consortium) /ID# 272650
Lake Charles, Louisiana, United States, 70605
Actively Recruiting
22
AA Medical Research Center - Grand Blanc /ID# 272496
Grand Blanc, Michigan, United States, 48439
Actively Recruiting
23
Albuquerque Center For Rheumatology /ID# 272301
Albuquerque, New Mexico, United States, 87102
Actively Recruiting
24
Joint And Muscle Research Institute /ID# 277290
Charlotte, North Carolina, United States, 28204
Actively Recruiting
25
DJL Clinical Research, PLLC /ID# 272387
Charlotte, North Carolina, United States, 28211-1064
Actively Recruiting
26
Paramount Medical Research and Consulting /ID# 272474
Middleburg Heights, Ohio, United States, 44130
Actively Recruiting
27
Altoona Center For Clinical Research /ID# 272479
Duncansville, Pennsylvania, United States, 16635
Actively Recruiting
28
Low Country Rheumatology /ID# 277607
Summerville, South Carolina, United States, 29486
Actively Recruiting
29
West Tennessee Research Institute /ID# 272453
Jackson, Tennessee, United States, 38305
Actively Recruiting
30
Arthritis & Rheumatology Research Institute /ID# 272299
Allen, Texas, United States, 75013
Actively Recruiting
31
Tekton Research - West Gate /ID# 272270
Austin, Texas, United States, 78745
Actively Recruiting
32
Trinity Universal Research Associates - Carrollton /ID# 272577
Carrollton, Texas, United States, 75007
Actively Recruiting
33
Arthritis Care Of Texas /ID# 277961
Corpus Christi, Texas, United States, 78415
Actively Recruiting
34
Accurate Clinical Research - Houston /ID# 272271
Houston, Texas, United States, 77089-6142
Actively Recruiting
35
Private Practice - Dr. Laila A. Hassan /ID# 272297
Houston, Texas, United States, 77089
Actively Recruiting
36
Southwest Rheumatology Research /ID# 272268
Mesquite, Texas, United States, 75150
Actively Recruiting
37
Texas Rheumatology Research Institute Llc /Id# 278010
Plano, Texas, United States, 75024
Actively Recruiting
38
Epic Medical Research /ID# 272656
Red Oak, Texas, United States, 75154
Actively Recruiting
39
DM Clinical Research - Tomball /ID# 272452
Tomball, Texas, United States, 77375
Actively Recruiting
40
Care Clinic - Calgary /ID# 274405
Calgary, Alberta, Canada, T2N 4L7
Actively Recruiting
41
Dr. Latha Naik Medical Professional Corporation /ID# 274403
Saskatoon, Saskatchewan, Canada, S7H 0P4
Actively Recruiting
42
L.K.N. Arthrocentrum /ID# 271932
Hlučín, Moravian-Silesian Region, Czechia, 748 01
Actively Recruiting
43
MEDICAL PLUS Research s.r.o /ID# 271926
Uherské Hradiště, Czechia, 686 01
Actively Recruiting
44
PV Medical Services s.r.o. /ID# 271934
Zlín, Czechia, 760 01
Actively Recruiting
45
Rheumateam Lahn-Dill-Siegerland /ID# 274858
Wetzlar, Hesse, Germany, 35578
Actively Recruiting
46
Universitaetsklinikum Bonn /ID# 272808
Bonn, North Rhine-Westphalia, Germany, 53127
Actively Recruiting
47
Krankenhaus Porz Am Rhein /ID# 272903
Cologne, North Rhine-Westphalia, Germany, 51149
Actively Recruiting
48
MVZ Rheumatologie und Autoimmunmedizin in Hamburg /ID# 272795
Hamburg, Germany, 20095
Actively Recruiting
49
Complex Rendelo Med Zrt. /ID# 272859
Székesfehérvár, Fejér, Hungary, 8000
Actively Recruiting
50
Vital-Medicina Kft. /ID# 272858
Veszprém, Fejér, Hungary, 8200
Actively Recruiting
51
Semmelweis Egyetem Reumatológiai és Immunológiai Klinika /ID# 273212
Budapest, Hungary, 1023
Actively Recruiting
52
Szegedi Tudomanyegyetem /ID# 272865
Szeged, Hungary, 6720
Actively Recruiting
53
Mics Centrum Medyczne Bydgoszcz /ID# 272975
Bydgoszcz, Kuyavian-Pomeranian Voivodeship, Poland, 85-068
Actively Recruiting
54
Malopolskie Centrum Kliniczne /ID# 272965
Krakow, Lesser Poland Voivodeship, Poland, 30-149
Actively Recruiting
55
Centrum Medyczne Reuma Park /ID# 272968
Warsaw, Masovian Voivodeship, Poland, 02-665
Actively Recruiting
56
Centrum Kliniczno-Badawcze J.Brzezicki, B. Gornikiewicz-Brzezicka Lekarze Spolka /ID# 272966
Elblag, Warmian-Masurian Voivodeship, Poland, 82-300
Actively Recruiting
57
Clinical Research Investigator Group /ID# 274821
Bayamón, Puerto Rico, 00960
Actively Recruiting
58
Centro Reumatologico De Caguas /ID# 277918
Caguas, Puerto Rico, 00725
Actively Recruiting
59
Reuviva Research Center /ID# 277140
Guaynabo, Puerto Rico, 00968-8050
Actively Recruiting
60
Santurce Clinical Trials and Infusion Center /ID# 277927
San Juan, Puerto Rico, 00909
Actively Recruiting
61
GCM Medical Group, PSC /ID# 273016
San Juan, Puerto Rico, 00917
Actively Recruiting
62
MEDMAN s.r.o. /ID# 278688
Martin, Žilina Region, Slovakia, 036 01
Actively Recruiting
63
SoonChunHyang University Hospital Cheonan /ID# 277624
Cheonan-si, Chungcheongnam-do, South Korea, 31151
Actively Recruiting
64
Ajou University Hospital /ID# 273647
Suwon, Gyeonggido, South Korea, 16499
Actively Recruiting
65
Hanyang University Seoul Hospital /ID# 273625
Seoul, Seoul Teugbyeolsi, South Korea, 04763
Actively Recruiting
66
SMG-SNU Boramae Medical Center /ID# 273627
Seoul, Seoul Teugbyeolsi, South Korea, 07061
Actively Recruiting
67
Complejo Hospitalario Universitario A Coruña /ID# 272609
A Coruña, A Coruna, Spain, 15006
Actively Recruiting
68
Hospital Universitari Parc Tauli /ID# 272607
Sabadell, Barcelona, Spain, 08208
Actively Recruiting
69
Hospital de Basurto /ID# 272610
Bilbao, Vizcaya, Spain, 48013
Actively Recruiting
70
Hospital General Universitario Gregorio Maranon /ID# 272616
Madrid, Spain, 28007
Actively Recruiting
71
Consorci Hospital General Universitario de Valencia /ID# 272615
Valencia, Spain, 46014
Actively Recruiting
Research Team
A
ABBVIE CALL CENTER
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
6
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here