Actively Recruiting
A Phase 2, Multicenter, Platform Study of Targeted Therapies for the Treatment of Adult Subjects With Moderately to Severely Active Rheumatoid Arthritis
Led by AbbVie · Updated on 2026-06-04
180
Participants Needed
92
Research Sites
39 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Rheumatoid Arthritis (RA) is a long-lasting inflammatory condition that causes joint pain, stiffness, swelling, and loss of function. Researchers are evaluating the effectiveness and safety of targeted treatments for adults with moderately to severely active RA who have not responded adequately to one or two prior biologic or targeted synthetic disease-modifying antirheumatic drugs (b/tsDMARDs). This study involves three substudies. Substudy 1 compares lutikizumab given alone to a placebo, Substudy 2 compares ravagalimab alone to a placebo, and Substudy 3 compares a combination of lutikizumab and ravagalimab to a placebo. Participants receive these treatments as subcutaneous injections. Approximately 180 adults will be randomly assigned to one of these treatment groups across about 65 locations worldwide. Participants will attend regular visits at clinics during the study where their response to treatment will be assessed through medical exams, blood tests, side effect monitoring, and questionnaires. The main outcomes measured include the percentage of participants achieving a 50% improvement in symptoms by week 12 and the number of participants experiencing adverse events up to about week 22. The study plans to end in November 2027.
CONDITIONS
Brief Title
A Study to Evaluate Different Targeted Therapies for Patients With Rheumatoid Arthritis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 years or older
- Diagnosed with moderately to severely active rheumatoid arthritis
- Previously treated for at least 3 months with one or two biologic or targeted synthetic disease-modifying antirheumatic drugs
- Currently on a stable dose of methotrexate
You will not qualify if you...
- Taking NSAIDs, acetaminophen, low-potency opioids, oral corticosteroids (≤10 mg/day prednisone equivalent), or inhaled corticosteroids unless on stable doses for at least 1 week prior to baseline
- History of arthritis starting before age 17 or diagnosed with inflammatory joint disease other than rheumatoid arthritis
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 12 weeks
Participants receive targeted therapies including Lutikizumab, Ravagalimab, or matching placebo injections to treat moderately to severely active rheumatoid arthritis.
Regular visits throughout 12 weeks for treatment administration and monitoring
Duration - Up to approximately 10 weeks following treatment
Participants are monitored for adverse events and treatment response up to approximately 22 weeks after starting treatment.
Visits for safety monitoring and assessment of adverse events
Trial Site Locations
Total: 92 locations
1
Sun Valley Arthritis Center /ID# 278331
Peoria, Arizona, United States, 85381
Actively Recruiting
2
Arensia Research Clinic /ID# 280896
Phoenix, Arizona, United States, 85015
Not Yet Recruiting
3
Private Practice - Dr. David S. Hallegua /ID# 277608
Beverly Hills, California, United States, 90211
Actively Recruiting
4
Advanced Clinical Research Center, LLC dba TriWest Research Associates /ID# 277826
Chula Vista, California, United States, 91910
Actively Recruiting
5
Newport Huntington Medical Group /ID# 272439
Huntington Beach, California, United States, 92648-5994
Actively Recruiting
6
Cohen Medical Centers /ID# 278341
Thousand Oaks, California, United States, 91360
Actively Recruiting
7
The Lundquist Institute /ID# 272481
Torrance, California, United States, 90502
Actively Recruiting
8
Inland Rheumatology and Osteoporosis Medical Group /ID# 272449
Upland, California, United States, 91786
Actively Recruiting
9
Tekton Research - Fort Collins - East Harmony Road /ID# 272472
Fort Collins, Colorado, United States, 80528
Actively Recruiting
10
Highlands Advanced Rheumatology And Arthritis Center - Avon Park /ID# 272298
Avon Park, Florida, United States, 33825
Actively Recruiting
11
Clinical Research Of West Florida - Phase I Unit /ID# 272428
Clearwater, Florida, United States, 33765
Actively Recruiting
12
Neoclinical Research - Hialeah /ID# 272070
Hialeah, Florida, United States, 33016
Actively Recruiting
13
South Florida Rheumatology /ID# 278339
Hollywood, Florida, United States, 33026
Actively Recruiting
14
Swati Shah, MD Rheumatology /ID# 273624
Jacksonville, Florida, United States, 32257
Actively Recruiting
15
Life Clinical Trials - Colonial Drive - Margate /ID# 272589
Margate, Florida, United States, 33063
Actively Recruiting
16
HMD Research LLC /ID# 272432
Orlando, Florida, United States, 32819
Actively Recruiting
17
Vitalia Research /ID# 272478
Palm Beach Gardens, Florida, United States, 33410
Actively Recruiting
18
Clinical Research Of West Florida - Tampa - North Howard Avenue /ID# 272755
Tampa, Florida, United States, 33606
Actively Recruiting
19
Northwestern Medicine - Northwestern Memorial Hospital /ID# 275422
Chicago, Illinois, United States, 60611
Actively Recruiting
20
Deerbrook Medical Associates /ID# 273439
Libertyville, Illinois, United States, 60048
Actively Recruiting
21
Advanced Quality Medical Research /ID# 277824
Orland Park, Illinois, United States, 60462
Actively Recruiting
22
Arnold Arthritis & Rheumatology /ID# 278354
Skokie, Illinois, United States, 60076
Actively Recruiting
23
Willow Rheumatology and Wellness /ID# 272691
Willowbrook, Illinois, United States, 60527
Actively Recruiting
24
Accurate Clinical Research (SMO/Network/Consortium) /ID# 272650
Lake Charles, Louisiana, United States, 70605
Actively Recruiting
25
AA Medical Research Center - Grand Blanc /ID# 272496
Grand Blanc, Michigan, United States, 48439
Actively Recruiting
26
Sahni Rheumatology & Therapy /ID# 278352
West Long Branch, New Jersey, United States, 07764
Actively Recruiting
27
Albuquerque Center For Rheumatology /ID# 272301
Albuquerque, New Mexico, United States, 87102
Actively Recruiting
28
Northwell Health Physician Partners Rheumatology At Great Neck /ID# 275621
Great Neck, New York, United States, 11021
Actively Recruiting
29
Joint And Muscle Research Institute /ID# 277290
Charlotte, North Carolina, United States, 28204
Actively Recruiting
30
DJL Clinical Research - Charlotte /ID# 272387
Charlotte, North Carolina, United States, 28211-1064
Actively Recruiting
31
Cape Fear Arthritis Care /ID# 272076
Leland, North Carolina, United States, 28451
Not Yet Recruiting
32
Paramount Medical Research and Consulting /ID# 272474
Middleburg Heights, Ohio, United States, 44130
Actively Recruiting
33
Altoona Center For Clinical Research /ID# 272479
Duncansville, Pennsylvania, United States, 16635
Actively Recruiting
34
Low Country Rheumatology /ID# 277607
Summerville, South Carolina, United States, 29486
Actively Recruiting
35
West Tennessee Research Institute /ID# 272453
Jackson, Tennessee, United States, 38305
Actively Recruiting
36
Arthritis & Rheumatology Research Institute /ID# 272299
Allen, Texas, United States, 75013
Actively Recruiting
37
Tekton Research - West Gate /ID# 272270
Austin, Texas, United States, 78745
Actively Recruiting
38
Trinity Universal Research Associates - Carrollton /ID# 272577
Carrollton, Texas, United States, 75007
Actively Recruiting
39
Arthritis Care Of Texas /ID# 277961
Corpus Christi, Texas, United States, 78415
Actively Recruiting
40
Accurate Clinical Research - Houston /ID# 272271
Houston, Texas, United States, 77089-6142
Actively Recruiting
41
Private Practice - Dr. Laila A. Hassan /ID# 272297
Houston, Texas, United States, 77089
Actively Recruiting
42
Biopharma Informatic /ID# 279189
Katy, Texas, United States, 77494
Actively Recruiting
43
Southwest Rheumatology Research /ID# 272268
Mesquite, Texas, United States, 75150
Actively Recruiting
44
Texas Rheumatology Research Institute Llc /Id# 278010
Plano, Texas, United States, 75024
Actively Recruiting
45
Epic Medical Research /ID# 272656
Red Oak, Texas, United States, 75154
Actively Recruiting
46
Texas Digestive Disease Consultants - Southlake /ID# 277652
Southlake, Texas, United States, 76092
Not Yet Recruiting
47
DM Clinical Research - Tomball /ID# 272452
Tomball, Texas, United States, 77375
Actively Recruiting
48
DM Clinical Research -Tomball RCH /ID# 281787
Tomball, Texas, United States, 77377
Actively Recruiting
49
Annapolis Rheumatology /ID# 279144
Fairfax, Virginia, United States, 22311
Not Yet Recruiting
50
Hoskinson Health & Wellness Clinic /ID# 281689
Gillette, Wyoming, United States, 82718
Not Yet Recruiting
51
Care Clinic - Calgary /ID# 274405
Calgary, Alberta, Canada, T2N 4L7
Actively Recruiting
52
Centre Hospitalier Universite De Sherbrooke - Hotel-Dieu Hospital /ID# 273711
Sherbrooke, Quebec, Canada, J1G 2E8
Actively Recruiting
53
Dr. Latha Naik Medical Professional Corporation /ID# 274403
Saskatoon, Saskatchewan, Canada, S7H 0P4
Actively Recruiting
54
L.K.N. Arthrocentrum /ID# 271932
Hlučín, Moravian-Silesian Region, Czechia, 748 01
Actively Recruiting
55
MEDICAL PLUS Research s.r.o /ID# 271926
Uherské Hradiště, Czechia, 686 01
Actively Recruiting
56
PV Medical Services s.r.o. /ID# 271934
Zlín, Czechia, 760 01
Actively Recruiting
57
Rheumateam Lahn-Dill-Siegerland /ID# 274858
Wetzlar, Hesse, Germany, 35578
Actively Recruiting
58
Universitaetsklinikum Bonn /ID# 272808
Bonn, North Rhine-Westphalia, Germany, 53127
Actively Recruiting
59
Krankenhaus Porz Am Rhein /ID# 272903
Cologne, North Rhine-Westphalia, Germany, 51149
Actively Recruiting
60
Mvz Rheuma /ID# 272795
Hamburg, Germany, 20095
Actively Recruiting
61
Szegedi Tudomanyegyetem /ID# 272865
Szeged, Csongrád megye, Hungary, 6720
Actively Recruiting
62
Complex Rendelo Med Zrt. /ID# 272859
Székesfehérvár, Fejér, Hungary, 8000
Actively Recruiting
63
Vital-Medicina Kft. /ID# 272858
Veszprém, Fejér, Hungary, 8200
Actively Recruiting
64
Semmelweis Egyetem Reumatológiai és Immunológiai Klinika /ID# 273212
Budapest, Hungary, 1023
Actively Recruiting
65
Revita Reumatologiai Rendelo (Revita Kft.) /ID# 281247
Budapest, Hungary, 1027
Actively Recruiting
66
Qualiclinic /ID# 281259
Budapest, Hungary, 1134
Actively Recruiting
67
Medicover Integrated Clinical Services - Bydgoszcz (SMO/Network/Consortium) /ID# 272975
Bydgoszcz, Kuyavian-Pomeranian Voivodeship, Poland, 85-068
Actively Recruiting
68
Szpital Uniwersytecki Nr 2 Im. Dr Jana Biziela W Bydgoszczy /ID# 281180
Bydgoszcz, Kuyavian-Pomeranian Voivodeship, Poland, 85-168
Actively Recruiting
69
Malopolskie Centrum Kliniczne /ID# 272965
Krakow, Lesser Poland Voivodeship, Poland, 30-149
Actively Recruiting
70
Centrum Nowoczesnych Terapii Dobry Lekarz sp.z.o.o. /ID# 281209
Krakow, Lesser Poland Voivodeship, Poland, 31-011
Actively Recruiting
71
Centrum Medyczne Reuma Park /ID# 272968
Warsaw, Masovian Voivodeship, Poland, 02-665
Actively Recruiting
72
Centrum Kliniczno-Badawcze J.Brzezicki, B. Gornikiewicz-Brzezicka Lekarze Spolka /ID# 272966
Elblag, Warmian-Masurian Voivodeship, Poland, 82-300
Actively Recruiting
73
Etyka Osrodek Badan Klinicznych /ID# 272974
Olsztyn, Warmian-Masurian Voivodeship, Poland, 10-117
Actively Recruiting
74
Clinical Research Investigator Group /ID# 274821
Bayamón, Puerto Rico, 00960
Actively Recruiting
75
Centro Reumatologico De Caguas /ID# 277918
Caguas, Puerto Rico, 00725
Actively Recruiting
76
Reuviva Research Center /ID# 277140
Guaynabo, Puerto Rico, 00968-8050
Actively Recruiting
77
Clinical Research Puerto Rico /ID# 281346
San Juan, Puerto Rico, 00909-1738
Actively Recruiting
78
Santurce Clinical Trials and Infusion Center /ID# 277927
San Juan, Puerto Rico, 00909
Actively Recruiting
79
GCM Medical Group, PSC /ID# 273016
San Juan, Puerto Rico, 00917
Actively Recruiting
80
MEDMAN s.r.o. /ID# 278688
Martin, Žilina Region, Slovakia, 036 01
Actively Recruiting
81
SoonChunHyang University Hospital Cheonan /ID# 277624
Cheonan-si, Chungcheongnam-do, South Korea, 31151
Actively Recruiting
82
Ajou University Hospital - Suwon-si /ID# 273647
Suwon, Gyeonggido, South Korea, 16499
Actively Recruiting
83
Hanyang University Seoul Hospital /ID# 273625
Seoul, Seoul Teugbyeolsi, South Korea, 04763
Actively Recruiting
84
SMG-SNU Boramae Medical Center /ID# 273627
Seoul, Seoul Teugbyeolsi, South Korea, 07061
Actively Recruiting
85
Complejo Hospitalario Universitario A Coruña /ID# 272609
A Coruña, A Coruna, Spain, 15006
Actively Recruiting
86
Hospital Universitari Parc Tauli /ID# 272607
Sabadell, Barcelona, Spain, 08208
Actively Recruiting
87
Hospital Universitario de Valme /ID# 281266
Seville, Sevilla, Spain, 41014
Actively Recruiting
88
Hospital de Basurto /ID# 272610
Bilbao, Vizcaya, Spain, 48013
Actively Recruiting
89
Hospital Universitario Reina Sofia /ID# 272613
Córdoba, Spain, 14004
Actively Recruiting
90
Hospital General Universitario Gregorio Maranon /ID# 272616
Madrid, Spain, 28007
Actively Recruiting
91
Consorci Hospital General Universitario de Valencia /ID# 272615
Valencia, Spain, 46014
Actively Recruiting
92
Taoyuan General Hospital /ID# 280044
Taoyuan City, Taiwan, 330
Actively Recruiting
Research Team
A
ABBVIE CALL CENTER
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
6
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