Actively Recruiting
A Real-world Study to Explore Personalized Treatment for Patients With Recurrent Gynecological Malignancies Based on Molecular Profiling and Multidisciplinary Team Consultation
Led by Sun Yat-sen University · Updated on 2025-08-27
200
Participants Needed
2
Research Sites
26 weeks
Total Duration
On this page
Sponsors
S
Sun Yat-sen University
Lead Sponsor
C
Cancer Hospital Chinese Academy of Medical Science, Shenzhen Center
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are investigating whether genomic sequencing combined with molecular tumor boards can improve treatment responses in patients with recurrent ovarian, cervical, or endometrial cancer. This real-world observational study has two parts: a retrospective analysis of past patients treated since January 2022, and a prospective study enrolling 200 patients to observe personalized treatment plans guided by molecular profiling and multidisciplinary consultation. In the retrospective part, data such as tumor genomic sequences, medical histories, treatment recommendations, and therapies used will be reviewed. The prospective part involves collecting tumor tissue and blood samples for next-generation sequencing to determine molecular profiles. An expert panel will suggest individualized treatments based on these profiles and patient data, while attending physicians will finalize treatment plans considering patient preferences, comorbidities, medication risks, insurance coverage, and available clinical trials. Participants will be followed for clinical outcomes, including overall response rates assessed after treatment cycles of 21 to 28 days. Researchers will also track progression-free survival and overall survival over two years. The study includes multidisciplinary consultations and molecular profiling to evaluate the effectiveness of personalized therapies, with the aim of improving care for patients with recurrent gynecological cancers.
CONDITIONS
Brief Title
A Study to Explore Personalized Treatment for Patients With Recurrent Gynecological Malignancies Based on MTB
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with recurrent ovarian, cervical, or endometrial cancer referred for multidisciplinary consultation by a gynecological oncologist
- Presence of at least one evaluable lesion
- Willingness to participate in multidisciplinary consultation
- Age 18 years or older
- Sufficient tumor tissue for next-generation sequencing with tumor content greater than 32%
- Informed consent provided indicating understanding of study procedures and willingness to participate
You will not qualify if you...
- Patients with concurrent malignancies
- Pregnant patients
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Varies depending on individual consultation schedules
Participants undergo molecular profiling of tumor tissue and multidisciplinary consultations to explore personalized treatment options.
1 to 3 visits depending on molecular profiling and consultation needs
Duration - Up to 2 years
Participants are monitored over time to assess treatment response and survival outcomes.
Assessments at the end of each treatment cycle (approximately every 3 to 4 weeks) and periodic follow-up visits
Trial Site Locations
Total: 2 locations
1
Sun Yat'sen University Cancer Center
Guangzhou, Guangdong, China, 510000
Actively Recruiting
2
Cancer Hospital Chinese Academy of Medical Sciences,Shenzhen Center
Shenzhen, Guangdong, China, 518000
Actively Recruiting
Research Team
X
Xiaolin Luo, PhD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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