Actively Recruiting
Study of Extracellular Vesicles (EV) in Patients Undergoing CAR-T Cell Therapies
Led by IRCCS Azienda Ospedaliero-Universitaria di Bologna · Updated on 2024-12-27
100
Participants Needed
1
Research Sites
104 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Patients with refractory/relapse hematologic oncology disease may benefit from innovative therapy such as Car-T cells. Factors strongly predictive of outcome and response are unknown. Extracellular vesicles are recognized as a mode of intercellular communication and are reminiscent of the cell of origin. They are currently candidates to be biomarkers for this biomarker of phenomena occurring in tissues. The working hypothesis is that they may be predictive of outcome and toxicity, as some preliminary data have suggested. Therefore, the aim of the study concerns I dentification of potential CAR-EV biomarkers associated with neurological toxicity after infusion of CAR-T cells.
CONDITIONS
Official Title
Study of Extracellular Vesicles (EV) in Patients Undergoing CAR-T Cell Therapies
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with any hematological malignancies (refractory/relapsed B cell lymphoma, B cell acute leukemia, or multiple myeloma) undergoing or planned for CAR-T cell infusion with a CAR-T cell product
- Age 18 years or older
- Provided written consent to participate in the study
You will not qualify if you...
- None
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
IRCCS Azienda Ospedaliero-Universitaria di Bologna
Bologna, Bologna, Italy, 40138
Actively Recruiting
Research Team
F
Francesca Bonifazi
CONTACT
E
Enrica Tomassini
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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