Actively Recruiting
Study of Izalontamab Brengitecan (BMS-986507) Versus Platinum-Pemetrexed for EGFR-mutated Non-small Cell Lung Cancer After Failure of EGFR TKI Therapy (IZABRIGHT-Lung01)
Led by Bristol-Myers Squibb · Updated on 2026-04-16
596
Participants Needed
186
Research Sites
288 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
A Study of Izalontamab Brengitecan (BMS-986507) versus Platinum-Pemetrexed for EGFR-mutated Non-small Cell Lung Cancer after failure of EGFR TKI Therapy
CONDITIONS
Official Title
Study of Izalontamab Brengitecan (BMS-986507) Versus Platinum-Pemetrexed for EGFR-mutated Non-small Cell Lung Cancer After Failure of EGFR TKI Therapy (IZABRIGHT-Lung01)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Non-squamous NSCLC not suitable for curative treatment
- Confirmed EGFR mutation (exon 19 deletion or L858R mutation)
- Disease progression after 3rd-generation EGFR TKI therapy (e.g., osimertinib)
- Eligible for platinum-based chemotherapy with cisplatin or carboplatin plus pemetrexed
You will not qualify if you...
- Inadequate organ or bone marrow function
- Presence of leptomeningeal metastases or spinal cord compression
- Poorly controlled systemic medical conditions
- Other protocol-defined exclusion criteria
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 186 locations
1
Local Institution - 0279
Irvine, California, United States, 92612
Not Yet Recruiting
2
Local Institution - 0154
Orange, California, United States, 92868
Not Yet Recruiting
3
Shaw Cancer Center
Edwards, Colorado, United States, 81632
Actively Recruiting
4
Local Institution - 0085
Gainesville, Florida, United States, 32610
Withdrawn
5
Local Institution - 0142
Pembroke Pines, Florida, United States, 33028
Not Yet Recruiting
6
Piedmont Healthcare
Atlanta, Georgia, United States, 30318
Actively Recruiting
7
John B Amos Cancer Center
Columbus, Georgia, United States, 31904
Actively Recruiting
8
Local Institution - 0153
Chicago, Illinois, United States, 60612
Not Yet Recruiting
9
Dana-Farber Cancer Institute
Boston, Massachusetts, United States, 02215
Actively Recruiting
10
Washington University School of Medicine
St Louis, Missouri, United States, 63108
Actively Recruiting
11
Renown Regional Medical Center
Reno, Nevada, United States, 89502
Actively Recruiting
12
Perlmutter Cancer Center at NYU Langone Hospital - Long Island
Mineola, New York, United States, 11501
Actively Recruiting
13
NYU Langone Health
New York, New York, United States, 10016
Actively Recruiting
14
Local Institution - 0158
New York, New York, United States, 10065
Not Yet Recruiting
15
Rochester General Hospital Infectious Disease
Rochester, New York, United States, 14621
Actively Recruiting
16
University Hospitals Cleveland Medical Center
Cleveland, Ohio, United States, 44106
Actively Recruiting
17
Local Institution - 0284
Columbus, Ohio, United States, 43210
Not Yet Recruiting
18
Providence Cancer Institute Franz Clinic
Portland, Oregon, United States, 97213
Actively Recruiting
19
Providence St. Vincent Medical Center
Portland, Oregon, United States, 97225
Actively Recruiting
20
Local Institution - 0171
Portland, Oregon, United States, 97239
Not Yet Recruiting
21
Hospital of the University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104
Actively Recruiting
22
Local Institution - 0088
Pittsburgh, Pennsylvania, United States, 15212
Not Yet Recruiting
23
Local Institution - 0268
Chattanooga, Tennessee, United States, 37404
Withdrawn
24
Tennessee Oncology
Nashville, Tennessee, United States, 37203
Actively Recruiting
25
Local Institution - 0025
Houston, Texas, United States, 77030
Not Yet Recruiting
26
Local Institution - 0173
San Antonio, Texas, United States, 78229
Not Yet Recruiting
27
University of Virginia Health System
Charlottesville, Virginia, United States, 22908
Actively Recruiting
28
Virginia Commonwealth University (Vcu)
Richmond, Virginia, United States, 23219
Actively Recruiting
29
Local Institution - 0008
Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina, C1426ANZ
Not Yet Recruiting
30
Local Institution - 0004
ABB, Buenos Aires F.D., Argentina, C1199ABB
Not Yet Recruiting
31
Local Institution - 0094
Córdoba, Córdoba Province, Argentina, 5016
Not Yet Recruiting
32
Local Institution - 0280
Wilrijk, Antwerpen, Belgium, 2610
Not Yet Recruiting
33
Local Institution - 0161
Auderghem, Bruxelles-Capitale, Région de, Belgium, 1160
Not Yet Recruiting
34
Local Institution - 0022
Yvoir, Namur, Belgium, 5530
Not Yet Recruiting
35
Local Institution - 0023
Ghent, Oost-Vlaanderen, Belgium, 9000
Not Yet Recruiting
36
Local Institution - 0024
Sint-Niklaas, Oost-Vlaanderen, Belgium, B-9100
Not Yet Recruiting
37
Local Institution - 0190
Calgary, Alberta, Canada, T2N 5G2
Not Yet Recruiting
38
Princess Margaret Cancer Centre
Toronto, Ontario, Canada, M5G 2M9
Actively Recruiting
39
Local Institution - 0184
Chicoutimi, Quebec, Canada, G7H 5H6
Not Yet Recruiting
40
Local Institution - 0185
Montreal, Quebec, Canada, H4J 1C5
Not Yet Recruiting
41
Local Institution - 0006
Santiago, Santiago Metropolitan, Chile, 0
Not Yet Recruiting
42
Local Institution - 0005
Santiago, Santiago Metropolitan, Chile, 7500921
Not Yet Recruiting
43
Local Institution - 0007
Santiago, Santiago Metropolitan, Chile, 8420383
Not Yet Recruiting
44
Local Institution - 0244
Beijing, Beijing Municipality, China, 100142
Not Yet Recruiting
45
Local Institution - 0259
Chongqing, Chongqing Municipality, China, 400030
Not Yet Recruiting
46
Fujian Cancer Hospital
Fuzhou, Fujian, China, 350014
Actively Recruiting
47
Jiangmen Center Hospital
Jiangmen, Guangdong, China, 0
Actively Recruiting
48
Local Institution - 0271
Anyang, Henan, China, 455000
Not Yet Recruiting
49
Local Institution - 0261
Luoyang, Henan, China, 471003
Not Yet Recruiting
50
Local Institution - 0267
Jingzhou, Hubei, China, 0
Not Yet Recruiting
51
Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology
Wuhan, Hubei, China, 430030
Actively Recruiting
52
Local Institution - 0255
Changsha, Hunan, China, 410013
Not Yet Recruiting
53
Local Institution - 0256
Xuzhou, Jiangsu, China, 221009
Not Yet Recruiting
54
Local Institution - 0247
Nanchang, Jiangxi, China, 330209
Not Yet Recruiting
55
Local Institution - 0246
Changchun, Jilin, China, 130000
Not Yet Recruiting
56
Local Institution - 0257
Shenyang, Liaoning, China, 110001
Not Yet Recruiting
57
Local Institution - 0248
Jinan, Shandong, China, 250117
Not Yet Recruiting
58
Local Institution - 0250
Shanghai, Shanghai Municipality, China, 200030
Not Yet Recruiting
59
Shanxi Cancer Hospital
Taiyuan, Shanxi, China, 030000
Actively Recruiting
60
Local Institution - 0252
Hangzhou, Zhejiang, China, 310022
Not Yet Recruiting
61
Local Institution - 0251
Linhai, Zhejiang, China, 317000
Not Yet Recruiting
62
Local Institution - 0260
Nanning, China, 530021
Not Yet Recruiting
63
Local Institution - 0249
Shanghai, China, 200032
Not Yet Recruiting
64
Local Institution - 0229
Valledupar, Cesar Department, Colombia, 200001
Not Yet Recruiting
65
Local Institution - 0228
Bogotá, Cundinamarca, Colombia, 111511
Not Yet Recruiting
66
Local Institution - 0227
Montería, Departamento de Córdoba, Colombia, 230002
Not Yet Recruiting
67
Local Institution - 0226
Cali, Valle del Cauca Department, Colombia, 760032
Not Yet Recruiting
68
Local Institution - 0014
Strasbourg, Alsace, France, 67091
Not Yet Recruiting
69
Local Institution - 0017
Toulouse, Haute-Garonne, France, 31059
Not Yet Recruiting
70
Local Institution - 0010
Lille, Hauts-de-France, France, 59037
Not Yet Recruiting
71
Local Institution - 0018
La Tronche, Isère, France, 38700
Not Yet Recruiting
72
Local Institution - 0170
Saint-Herblain, Loire-Atlantique, France, 44805
Not Yet Recruiting
73
Local Institution - 0162
Bron, Rhône, France, 69677
Not Yet Recruiting
74
Local Institution - 0019
Villejuif, Val-de-Marne, France, 94800
Not Yet Recruiting
75
Local Institution - 0012
Marseille, France, 13915
Not Yet Recruiting
76
Local Institution - 0278
Nantes, France, 44200
Not Yet Recruiting
77
Local Institution - 0011
Paris, France, 75248
Not Yet Recruiting
78
Local Institution - 0015
Paris, France, 75970
Not Yet Recruiting
79
Local Institution - 0207
Esslingen am Neckar, Baden-Wurttemberg, Germany, 73730
Not Yet Recruiting
80
Local Institution - 0238
Esslingen am Neckar, Baden-Wurttemberg, Germany, 73730
Not Yet Recruiting
81
Local Institution - 0212
Stuttgart, Baden-Wurttemberg, Germany, 70376
Not Yet Recruiting
82
Local Institution - 0236
Donauwörth, Bavaria, Germany, 86609
Not Yet Recruiting
83
Local Institution - 0209
Oldenburg, Lower Saxony, Germany, 26121
Not Yet Recruiting
84
Local Institution - 0213
Cologne, North Rhine-Westphalia, Germany, 51109
Not Yet Recruiting
85
Local Institution - 0208
Chemnitz, Saxony, Germany, 09116
Not Yet Recruiting
86
Local Institution - 0274
Kiel, Schleswig-Holstein, Germany, 24105
Not Yet Recruiting
87
Local Institution - 0211
Berlin, Germany, 13125
Not Yet Recruiting
88
Local Institution - 0215
Gauting, Germany, 82131
Not Yet Recruiting
89
Local Institution - 0242
Hamburg, Germany, 22307
Not Yet Recruiting
90
Local Institution - 0210
Heidelberg, Germany, 69126
Not Yet Recruiting
91
Local Institution - 0239
Kassel, Germany, 34125
Not Yet Recruiting
92
Local Institution - 0241
Ulm, Germany, 89081
Not Yet Recruiting
93
Local Institution - 0054
Athens, Attikí, Greece, 115 27
Not Yet Recruiting
94
Local Institution - 0060
Chaïdári, Attikí, Greece, 124 62
Not Yet Recruiting
95
Local Institution - 0056
Thessaloniki, Kentrikí Makedonía, Greece, 540 07
Not Yet Recruiting
96
Local Institution - 0062
Thessaloniki, Thessaloníki, Greece, 570 10
Not Yet Recruiting
97
Local Institution - 0083
Ahmedabad, Gujarat, India, 380016
Withdrawn
98
Local Institution - 0073
Ahmedabad, Gujarat, India, 380054
Not Yet Recruiting
99
Local Institution - 0072
Gurugram, Haryana, India, 122001
Withdrawn
100
Local Institution - 0069
Bengaluru, Karnataka, India, 560017
Not Yet Recruiting
101
Local Institution - 0077
Mumbai, Maharashtra, India, 400 057
Not Yet Recruiting
102
Local Institution - 0071
Mumbai, Maharashtra, India, 400012
Not Yet Recruiting
103
Local Institution - 0097
Nagpur, Maharashtra, India, 440001
Not Yet Recruiting
104
Local Institution - 0070
New Delhi, National Capital Territory of Delhi, India, 110029
Not Yet Recruiting
105
Local Institution - 0078
Howrah, West Bengal, India, 711103
Withdrawn
106
Local Institution - 0028
Ravenna, Emilia-Romagna, Italy, 48121
Not Yet Recruiting
107
Local Institution - 0036
Aviano, Friuli Venezia Giulia, Italy, 33081
Not Yet Recruiting
108
Local Institution - 0031
Orbassano, Piedmont, Italy, 10043
Not Yet Recruiting
109
Local Institution - 0277
Candiolo, Torino, Italy, 10060
Not Yet Recruiting
110
Local Institution - 0137
Avellino, Italy, 83100
Not Yet Recruiting
111
Local Institution - 0032
Milan, Italy, 20141
Not Yet Recruiting
112
Local Institution - 0034
Naples, Italy, 80131
Not Yet Recruiting
113
Local Institution - 0029
Parma, Italy, 43126
Not Yet Recruiting
114
Local Institution - 0196
Nagoya, Aichi-ken, Japan, 464-8681
Not Yet Recruiting
115
Local Institution - 0191
Kashiwa, Chiba, Japan, 277-8577
Not Yet Recruiting
116
Local Institution - 0203
Tōon, Ehime, Japan, 791-0295
Not Yet Recruiting
117
Local Institution - 0201
Kurume, Fukuoka, Japan, 830-0011
Not Yet Recruiting
118
Local Institution - 0217
Sapporo, Hokkaido, Japan, 003-0804
Not Yet Recruiting
119
Local Institution - 0199
Nishinomiya, Hyōgo, Japan, 663-8501
Not Yet Recruiting
120
Local Institution - 0193
Yokohama, Kanagawa, Japan, 2418515
Not Yet Recruiting
121
Local Institution - 0192
Sendai, Miyagi, Japan, 9810914
Not Yet Recruiting
122
Local Institution - 0200
Kurashiki, Okayama-ken, Japan, 710-8602
Not Yet Recruiting
123
Local Institution - 0198
Hirakata, Osaka, Japan, 573-1191
Not Yet Recruiting
124
Local Institution - 0204
Ōsaka-sayama, Osaka, Japan, 589-8511
Not Yet Recruiting
125
Local Institution - 0194
Ina-machi, Saitama, Japan, 362-0806
Withdrawn
126
Local Institution - 0197
Hamamatsu, Shizuoka, Japan, 431-3192
Not Yet Recruiting
127
Local Institution - 0195
Nagaizumi-cho,Sunto-gun, Shizuoka, Japan, 411-8777
Not Yet Recruiting
128
Local Institution - 0202
Koto-ku, Tokyo, Japan, 135-8550
Not Yet Recruiting
129
Local Institution - 0225
Mexico City, Mexico City, Mexico, 03100
Not Yet Recruiting
130
Local Institution - 0224
Oaxaca City, Oaxaca, Mexico, 68020
Not Yet Recruiting
131
Local Institution - 0222
Chihuahua City, Mexico, 31203
Not Yet Recruiting
132
Local Institution - 0223
Mexico City, Mexico, 14210
Not Yet Recruiting
133
Local Institution - 0163
Harderwijk, Gelderland, Netherlands, 3844 DG
Not Yet Recruiting
134
Local Institution - 0216
Amsterdam, North Holland, Netherlands, 1066 CX
Not Yet Recruiting
135
Local Institution - 0164
Amsterdam, North Holland, Netherlands, 1081 HV
Not Yet Recruiting
136
Local Institution - 0103
Drammen, Buskerud, Norway, 3004
Not Yet Recruiting
137
Local Institution - 0106
Bergen, Hordaland, Norway, 5021
Not Yet Recruiting
138
Local Institution - 0105
Oslo, Norway, 0450
Not Yet Recruiting
139
Local Institution - 0220
Lublin, Lublin Voivodeship, Poland, 20-954
Not Yet Recruiting
140
Local Institution - 0231
Gdynia, Pomeranian Voivodeship, Poland, 81-519
Not Yet Recruiting
141
Local Institution - 0219
Bydgoszcz, Poland, 85796
Not Yet Recruiting
142
Local Institution - 0120
Bucharest, Bucharest, Romania, 013812
Not Yet Recruiting
143
Local Institution - 0123
Bucharest, Bucharest, Romania, 022328
Not Yet Recruiting
144
Local Institution - 0132
Florești, Cluj, Romania, 407280
Not Yet Recruiting
145
Local Institution - 0130
Craiova, Dolj, Romania, 200746
Not Yet Recruiting
146
Local Institution - 0115
Bucharest, Romania, 020335
Not Yet Recruiting
147
Local Institution - 0133
Cluj-Napoca, Romania, 400015
Not Yet Recruiting
148
Local Institution - 0124
Iași, Romania, 700106
Not Yet Recruiting
149
Local Institution - 0119
Iași, Romania, 700483
Not Yet Recruiting
150
Local Institution - 0263
Singapore, Singapore, 169610
Not Yet Recruiting
151
Local Institution - 0262
Singapore, Singapore, 308442
Not Yet Recruiting
152
Local Institution - 0089
Cheongju-si, Chungcheongbuk-do [Chungbuk], South Korea, 28644
Not Yet Recruiting
153
Local Institution - 0043
Goyang-si, Kyǒnggi-do, South Korea, 10408
Not Yet Recruiting
154
Local Institution - 0044
Seongnam, Kyǒnggi-do, South Korea, 13620
Not Yet Recruiting
155
Local Institution - 0046
Suwon, Kyǒnggi-do, South Korea, 16247
Not Yet Recruiting
156
Local Institution - 0095
Seoul, Seoul-teukbyeolsi [Seoul], South Korea, 03080
Not Yet Recruiting
157
Local Institution - 0045
Seoul, Seoul-teukbyeolsi [Seoul], South Korea, 03722
Not Yet Recruiting
158
Local Institution - 0092
Seoul, Seoul-teukbyeolsi [Seoul], South Korea, 05505
Not Yet Recruiting
159
Local Institution - 0042
Seoul, Seoul-teukbyeolsi [Seoul], South Korea, 06351
Not Yet Recruiting
160
Local Institution - 0218
Barcelona, Barcelona [Barcelona], Spain, 08035
Not Yet Recruiting
161
Local Institution - 0177
Barcelona, Catalunya [Cataluña], Spain, 08041
Not Yet Recruiting
162
Local Institution - 0175
Madrid, Madrid, Comunidad de, Spain, 28009
Not Yet Recruiting
163
Local Institution - 0206
Madrid, Madrid, Comunidad de, Spain, 28041
Not Yet Recruiting
164
Local Institution - 0176
Madrid, Madrid, Comunidad de, Spain, 28046
Not Yet Recruiting
165
Local Institution - 0181
Majadahonda, Madrid, Comunidad de, Spain, 28222
Not Yet Recruiting
166
Local Institution - 0178
Málaga, Spain, 29011
Not Yet Recruiting
167
Local Institution - 0182
Seville, Spain, 41013
Not Yet Recruiting
168
Local Institution - 0180
Valencia, Spain, 46026
Not Yet Recruiting
169
Local Institution - 0179
Zaragoza, Spain, 50009
Not Yet Recruiting
170
Kantonsspital Baden
Baden, Canton of Aargau, Switzerland, 5404
Actively Recruiting
171
Cantonal Hospital St.Gallen
Sankt Gallen, Canton of St. Gallen, Switzerland, 9007
Actively Recruiting
172
Local Institution - 0189
Bellinzona, Switzerland, 6500
Not Yet Recruiting
173
E-Da hospital
Kaohsiung City, Taiwan, 82445
Actively Recruiting
174
Taichung Veterans General Hospital
Taichung, Taiwan, 407
Actively Recruiting
175
National Cheng Kung University Hospital
Tainan, Taiwan, 704
Actively Recruiting
176
National Taiwan University Hospital
Taipei, Taiwan, 10002
Actively Recruiting
177
Taipei Medical University Hospital
Taipei, Taiwan, 110
Actively Recruiting
178
Taipei Veterans General Hospital
Taipei, Taiwan, 11217
Actively Recruiting
179
Local Institution - 0265
Bangkok, Bangkok, Thailand, 10700
Not Yet Recruiting
180
Local Institution - 0272
Mueng, Changwat Khon Kaen, Thailand, 40002
Not Yet Recruiting
181
Local Institution - 0264
Bangkok, Thailand, 10330
Not Yet Recruiting
182
Local Institution - 0266
Songkhla, Thailand, 90110
Not Yet Recruiting
183
Local Institution - 0110
Glasgow, Glasgow City, United Kingdom, G12 0YN
Not Yet Recruiting
184
Local Institution - 0061
London, Kensington and Chelsea, United Kingdom, SW3 6JJ
Not Yet Recruiting
185
Local Institution - 0140
London, London, City of, United Kingdom, E1 1RD
Not Yet Recruiting
186
Local Institution - 0281
Sulton, Surrey, United Kingdom, SM25PT
Not Yet Recruiting
Research Team
B
BMS Clinical Trials Contact Center www.BMSClinicalTrials.com
CONTACT
F
First line of the email MUST contain NCT # and Site #.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
5
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