Actively Recruiting

Phase Not Applicable
Age: 16Years - 55Years
All Genders
Healthy Volunteers
NCT06036316

Study of Language Disorders and Interactions Between Mnesic Capabilities and Semantic Competencies in Patients With Psychosis

Led by Centre Psychothérapique de Nancy · Updated on 2026-03-27

90

Participants Needed

1

Research Sites

122 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

This research concerns the study of language disorders of patients present in the spectrum of psychosis. It is indeed accepted that psychotic disorders are associated with language difficulties, which are only poorly highlighted thanks to reusable tools in clinical practice. These language disorders impact communication, and concern many linguistic domains, thus covering phonology, lexicon, semantics, morphosyntax and pragmatics. It therefore seems relevant to characterize these language disorders and to assess to what extent they interact with the other symptoms of the pathology, in particular the course of the thought disorder and the neuropsychological symptoms. In addition, this study is particularly interested in the interactions between working memory capacities and those related to syntax. It is intended for different patients suffering from psychotic disorders of different intensities, treated in the Psychotherapeutic Center of Nancy. Patients suffering from at-risk mental state (ARMS), first episode of psychosis (FEP) or schizophrenia will benefit from a complete language assessment, evaluating each domain mentioned above, on the expressive and understanding sides. The results of the language assessment will be compared with those of a control group in the same tests. They will also be analyzed with regard to the neuropsychological and psychiatric elements noted in the patient's medical file, in order to highlight possible associations between language skills, neuropsychological and psychiatric symptoms in this patient population.

CONDITIONS

Official Title

Study of Language Disorders and Interactions Between Mnesic Capabilities and Semantic Competencies in Patients With Psychosis

Who Can Participate

Age: 16Years - 55Years
All Genders
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  • Patient affiliated or entitled to a social security scheme
  • Patient having received informed information on the study and having co-signed a consent to participate
  • For minors, at least one parent or guardian informed and not objecting to participation
  • Native language is French
  • For ARMS and FEP patients: age between 16 and 35 years
  • ARMS or FEP criteria met as defined by CAARMS or SPI-A
  • For patients with schizophrenia: age between 16 and 55 years
  • Diagnosis of schizophrenia per DSM V
  • Meet criteria for Disorganization of Speech and Formal Thought Disorder as defined by the TLC Rating Scale
  • For healthy volunteers: age between 16 and 55 years
  • Parental authorization for minors
Not Eligible

You will not qualify if you...

  • Pregnant, parturient, or nursing mother
  • Person deprived of liberty by legal decision
  • Person in life-threatening emergency
  • Adult under legal protection (guardianship, curatorship, safeguard of justice)
  • Adult unable to consent and not under legal protection
  • Impairment preventing participation or understanding of information
  • Abuse or dependence on any substance excluding cannabis
  • For healthy volunteers: evolving psychiatric pathology (DSM IV axis I) except anxiety disorder
  • Presence of developmental disorder of oral or written language

AI-Screening

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Trial Site Locations

Total: 1 location

1

Centre Psychothérapeutique de Nancy

Laxou, France, France, 54520

Actively Recruiting

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Research Team

A

Anaëlle PAJAUD

CONTACT

N

Naoual MELLOUKI, PhD

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

NON_RANDOMIZED

Model

PARALLEL

Primary Purpose

DIAGNOSTIC

Number of Arms

3

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