Frontline sigvotatug vedotin plus pembrolizumab vs pembrolizumab for non-small cell lung cancer with PD-L1 tumor proportion score ≥50%: phase III study design.
Martin Reck, Shun Lu, Kenneth J O'Byrne...
https://pubmed.ncbi.nlm.nih.gov/41388832Actively Recruiting
Phase 3
Age: 18Years +
All Genders
ID06758401
A Phase 3 Study of Sigvotatug Vedotin Plus Pembrolizumab Versus Pembrolizumab Alone as First Treatment for PD-L1 High Advanced or Metastatic Non-Small Cell Lung Cancer
Led by Pfizer · Updated on 2026-04-20
714
Participants Needed
329
Research Sites
25 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating a new combination treatment of Sigvotatug Vedotin plus pembrolizumab compared to pembrolizumab alone in people with non-small cell lung cancer (NSCLC) that has high levels of PD-L1 protein. This study focuses on patients with advanced NSCLC (Stage 3 or 4) where PD-L1 is present in at least 50% of the cancer cells. The aim is to see how these treatments work as first-line therapy for this type of lung cancer. Participants will receive pembrolizumab through an intravenous infusion every 6 weeks at the study clinic. Half of the participants will also receive Sigvotatug Vedotin every 2 weeks by intravenous infusion alongside pembrolizumab. Pembrolizumab treatment can continue for up to about two years, while those receiving Sigvotatug Vedotin may continue until their cancer no longer responds to the treatment. During the study, participants will visit the clinic regularly for monitoring and treatment. Researchers will measure overall survival and progression-free survival, with assessments done by independent review and investigators over approximately two years and up to four years for some outcomes. They will also track responses to treatment, side effects, and drug levels in the blood to better understand how the treatments affect patients with NSCLC.
CONDITIONS
Brief Title
This is a Study to Learn About How the Combination of the Study Medicines Sigvotatug Vedotin Plus Pembrolizumab Works in People With Non-small Cell Lung Cancer With High Levels of PD-L1.
Who Can Participate
Age: 18Years +
All Genders
Eligibility Criteria
You may qualify if you...
- Have pathologically confirmed Stage IIIB, IIIC, or IV non-small cell lung cancer not suitable for surgery or definitive chemoradiation
- For non-squamous NSCLC, documented negative test results for EGFR, ALK, ROS1, and no known alterations in NTRK, BRAF, RET, MET
- Tumor has PD-L1 expression in 50% or more of tumor cells
- Measurable disease based on RECIST v1.1 criteria
- Eligible for pembrolizumab monotherapy according to local guidelines
- Acute effects of prior therapy resolved to baseline or Grade 1 or less (except non-safety-risk adverse events)
You will not qualify if you...
- Life expectancy less than 3 months
- Medical or psychiatric conditions increasing risk for study participation
- History of another cancer within 3 years or residual disease from prior cancer
- Known allergy or intolerance to sigvotatug vedotin or pembrolizumab components
- Respiratory conditions including noninfectious or drug-induced interstitial lung disease or pneumonitis, DLCO less than 50%, or severe pulmonary disease unrelated to cancer
- Active central nervous system lesions; treated brain metastases allowed if inactive and less than 0.5 cm
- Recent major surgery within 21 days or minor surgery within 7 days before first dose
- Receipt of live vaccine within 30 days before first dose
- Pre-existing peripheral neuropathy Grade 2 or higher
- Uncontrolled diabetes mellitus with high HbA1c or symptoms
- Prior immune-related adverse events causing PD-(L)1 discontinuation or requiring high-dose steroids or immunosuppressive therapy
- Autoimmune disease requiring systemic treatment in past 2 years
- Prior solid organ or bone marrow transplantation
- Current high-dose steroid or immune suppressant use
- Prior therapy with MMAE-derived drugs, IB6 agents, or systemic therapy for advanced NSCLC (with some exceptions for adjuvant therapy)
- Recent radiotherapy or chemotherapy within specified timeframes
- History or current infection including active HIV, HBV, or HCV
- Severe uncontrolled heart or brain blood vessel conditions in past 6 months
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
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Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Treatment
Duration - Up to 4 years or until disease progression or discontinuation
Participants receive the study medicines, Sigvotatug Vedotin plus Pembrolizumab or Pembrolizumab alone, administered as IV infusions to treat non-small cell lung cancer.
Multiple infusion visits according to treatment cycles
Follow-up
Duration - Approximately 2 years
Participants are monitored for overall survival, disease progression, and safety after treatment ends.
Periodic follow-up visits for assessments
Trial Site Locations
Total: 329 locations
1
Providence St. Jude Medical Center Virginia K. Crosson Cancer Center and Infusion Center
Fullerton, California, United States, 92835
Actively Recruiting
2
Providence St. Jude Medical Center
Fullerton, California, United States, 92835
Actively Recruiting
3
St. Jude Heritage Medical Group - Fullerton Plaza Multi-Specialty Clinic (Pulmonary Function Test)
Fullerton, California, United States, 92835
Actively Recruiting
4
Intermountain Health Cancer Center Lutheran Hospital
Golden, Colorado, United States, 80401
Actively Recruiting
5
Cancer Centers of Colorado St. Mary's Regional Hospital
Grand Junction, Colorado, United States, 81501
Actively Recruiting
6
Intermountain Health St. Mary's Regional Hospital
Grand Junction, Colorado, United States, 81501
Actively Recruiting
7
Intermountain Health
Grand Junction, Colorado, United States, 81505
Actively Recruiting
8
Intermountain Health Lutheran Hospital
Wheat Ridge, Colorado, United States, 80401
Actively Recruiting
9
Washington DC Veterans Affairs Medical Center
Washington D.C., District of Columbia, United States, 20422
Actively Recruiting
10
Mid Florida Hematology and Oncology Center
Orange City, Florida, United States, 32763
Actively Recruiting
11
BRCR Global
Plantation, Florida, United States, 33322
Actively Recruiting
12
Endeavor Health
Elmhurst, Illinois, United States, 60126
Actively Recruiting
13
Hope and Healing Cancer Services
Hinsdale, Illinois, United States, 60521
Actively Recruiting
14
Endeavor Health
Naperville, Illinois, United States, 60540
Actively Recruiting
15
Hope and Healing Cancer Services
New Lenox, Illinois, United States, 60451
Actively Recruiting
16
Maine Medical Center
Portland, Maine, United States, 04102
Actively Recruiting
17
MaineHealth Cancer Care - Scarborough
Scarborough, Maine, United States, 04074
Actively Recruiting
18
MaineHealth Cancer Care and IV Therapy - South Portland
South Portland, Maine, United States, 04106
Actively Recruiting
19
Minnesota Oncology Hematology, PA
Burnsville, Minnesota, United States, 55337
Actively Recruiting
20
Minnesota Oncology Hematology PA
Coon Rapids, Minnesota, United States, 55433
Actively Recruiting
21
M Health Fairview Cancer Clinic-Edina
Edina, Minnesota, United States, 55435
Actively Recruiting
22
Minnesota Oncology Hematology PA
Edina, Minnesota, United States, 55435
Actively Recruiting
23
Minnesota Oncology Hematology PA
Maple Grove, Minnesota, United States, 55369
Actively Recruiting
24
M Health Fairview St. John's Hospital
Maplewood, Minnesota, United States, 55109
Actively Recruiting
25
Minnesota Oncology Hematology PA
Maplewood, Minnesota, United States, 55109
Actively Recruiting
26
Hennepin County Medical Center
Minneapolis, Minnesota, United States, 55415
Actively Recruiting
27
North Memorial Health Cancer Center
Robbinsdale, Minnesota, United States, 55422
Actively Recruiting
28
Metro Minnesota Community Oncology Research Consortium (MMCORC)
Saint Louis Park, Minnesota, United States, 55426
Actively Recruiting
29
Park Nicollet Frauenshuh Cancer Center
Saint Louis Park, Minnesota, United States, 55426
Actively Recruiting
30
Regions Hospital
Saint Paul, Minnesota, United States, 55101
Actively Recruiting
31
Minnesota Oncology Hematology, P.A. Cornerstone Medical Specialty Center
Woodbury, Minnesota, United States, 55125
Actively Recruiting
32
Jackson Oncology Associates, PLLC
Jackson, Mississippi, United States, 39202
Actively Recruiting
33
Jackson Oncology Associates, PLLC
Jackson, Mississippi, United States, 39216
Actively Recruiting
34
Oncology Hematology West, PC dba Nebraska Cancer Specialists - Fremont
Fremont, Nebraska, United States, 68025
Actively Recruiting
35
Oncology Hematology West, PC dba Nebraska Cancer Specialists - Grand Island
Grand Island, Nebraska, United States, 68803
Actively Recruiting
36
Oncology Hematology West, PC dba Nebraska Cancer Specialists - Regional
Grand Island, Nebraska, United States, 68803
Actively Recruiting
37
Cancer Partners of Nebraska - April Sampson Cancer Center
Lincoln, Nebraska, United States, 68516
Actively Recruiting
38
Oncology Hematology West P.C. dba Nebraska Cancer Specialists - Methodist
Omaha, Nebraska, United States, 68114
Actively Recruiting
39
Oncology Hematology West, PC dba Nebraska Cancer Specialists - Bergan
Omaha, Nebraska, United States, 68124
Actively Recruiting
40
Oncology Hematology West P.C. dba Nebraska Cancer Specialists
Omaha, Nebraska, United States, 68130
Actively Recruiting
41
Hematology Oncology Associates of Rockland
Nyack, New York, United States, 10960
Actively Recruiting
42
Carolina Cancer Research Center
Wilson, North Carolina, United States, 27893
Actively Recruiting
43
Gabrail Cancer Center Research
Canton, Ohio, United States, 44718
Actively Recruiting
44
The University of Texas, MD Anderson Cancer Center - Woodlands
Conroe, Texas, United States, 77384
Actively Recruiting
45
Renovatio Clinical - El Paso
El Paso, Texas, United States, 79915
Actively Recruiting
46
The University of Texas MD Anderson Cancer Center Diagnostic Imaging
Houston, Texas, United States, 77030
Actively Recruiting
47
The University of Texas MD Anderson Cancer Center Investigational Pharmacy Services
Houston, Texas, United States, 77030
Actively Recruiting
48
The University of Texas, MD Anderson Cancer Center- Interventional Radiology
Houston, Texas, United States, 77030
Actively Recruiting
49
University of Texas MD Anderson Cancer Center
Houston, Texas, United States, 77030
Actively Recruiting
50
The University of Texas MD Anderson Cancer Center Clinical Research Imaging
Houston, Texas, United States, 77054
Actively Recruiting
51
The University of Texas, MD Anderson Cancer Center - West Houston
Houston, Texas, United States, 77079
Actively Recruiting
52
Community Clinical Trials
Kingwood, Texas, United States, 77339
Actively Recruiting
53
The University of Texas, MD Anderson Cancer Center - League City
League City, Texas, United States, 77573
Actively Recruiting
54
The University of Texas, MD Anderson Cancer Center - Sugar Land
Sugar Land, Texas, United States, 77478
Actively Recruiting
55
Renovatio Clinical
The Woodlands, Texas, United States, 77380
Actively Recruiting
56
Woodlands Radiology
The Woodlands, Texas, United States, 77381
Actively Recruiting
57
American Oncology Network Vista Oncology Division-West office
Olympia, Washington, United States, 98502
Actively Recruiting
58
American Oncology Network Vista Oncology Division-East office
Olympia, Washington, United States, 98506
Actively Recruiting
59
Fundación Respirar
Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina, C1426ABP
Not Yet Recruiting
60
Centro de Investigación Pergamino
Pergamino, Buenos Aires, Argentina, B2700CPM
Not Yet Recruiting
61
Centro de Investigaciones Medicas y Desarrollo LC
Buenos Aires, Cdad. Autónoma de Buenos Aires, Argentina, C 1113
Actively Recruiting
62
Fundacion Ars Medica
San Salvador de Jujuy, Jujuy Province, Argentina, 4600
Not Yet Recruiting
63
Fundacion Medica de Rio Negro y Neuquen
Cipolletti, Río Negro Province, Argentina, 8324
Actively Recruiting
64
Fundacion Estudios Clinicos
Rosario, Santa Fe Province, Argentina, 2000
Not Yet Recruiting
65
Sanatorio Británico
Rosario, Santa Fe Province, Argentina, S2000CVB
Not Yet Recruiting
66
Sanatorio Parque
Rosario, Santa Fe Province, Argentina, S2000DSV
Not Yet Recruiting
67
Hospital Provincial del Centenario
Rosario, Santa Fe Province, Argentina, S2002KDS
Not Yet Recruiting
68
Centro Oncologico Korben
Buenos Aires, Argentina, 1426
Actively Recruiting
69
Instituto Argentino de Diagnóstico y Tratamiento (IADT)
Buenos Aires, Argentina, C1122AAL
Not Yet Recruiting
70
Centro Urológico Profesor Bengió
Córdoba, Argentina, 5000
Not Yet Recruiting
71
Sanatorio Privado de la Cañada
Córdoba, Argentina, 5000
Not Yet Recruiting
72
Hospital Privado Universitario de Córdoba
Córdoba, Argentina, 5016
Not Yet Recruiting
73
Centro Medico Privado CEMAIC
Córdoba, Argentina, X5008AAC
Not Yet Recruiting
74
Instituto San Marcos
San Juan, Argentina, 5400
Not Yet Recruiting
75
Coffs Harbour Health Campus
Coffs Harbour, New South Wales, Australia, 2450
Actively Recruiting
76
Macquarie University
North Ryde, New South Wales, Australia, 2109
Actively Recruiting
77
Campbelltown Hospital
Sydney, New South Wales, Australia, 2560
Actively Recruiting
78
Sunshine Coast University Hospital
Birtinya, Queensland, Australia, 4575
Actively Recruiting
79
Townsville University Hospital
Douglas, Queensland, Australia, 4814
Actively Recruiting
80
Gympie Hospital
Gympie, Queensland, Australia, 4570
Actively Recruiting
81
Nambour General Hospital
Nambour, Queensland, Australia, 4560
Actively Recruiting
82
Princess Alexandra Hospital
Woolloongabba, Queensland, Australia, 4102
Actively Recruiting
83
Sir Charles Gairdner Hospital
Perth, Western Australia, Australia, 6009
Actively Recruiting
84
Ordensklinikum Linz GmbH Elisabethinen
Linz, Upper Austria, Austria, 4020
Actively Recruiting
85
Medizinische Universität Graz
Graz, Austria, 8036
Not Yet Recruiting
86
Medizinische Universität Wien
Vienna, Austria, 1090
Not Yet Recruiting
87
AZ Sint-Maarten
Mechelen, Antwerpen, Belgium, 2800
Actively Recruiting
88
UZ Brussel
Brussels, Bruxelles-capitale, Région de, Belgium, 1090
Actively Recruiting
89
Grand Hôpital de Charleroi
Charleroi, Hainaut, Belgium, 6060
Actively Recruiting
90
Algemeen Ziekenhuis klina
Brasschaat, Belgium, 2930
Actively Recruiting
91
Centre Hospitalier Universitaire de Liège - Domaine Universitaire du Sart Tilman
Liège, Belgium, 4000
Actively Recruiting
92
Crio - Centro Regional Integrado de Oncologia
Fortaleza, Ceará, Brazil, 60336232
Actively Recruiting
93
Centro de Pesquisa Clínica do Instituto do Câncer do Ceará
Fortaleza, Ceará, Brazil, 60430235
Actively Recruiting
94
Afecc Associacao Feminina Educacao Combate Cancer
Vitória, Espírito Santo, Brazil, 29043-260
Actively Recruiting
95
Instituto D'Or de Pesquisa e Ensino - Hospital São Rafael
Salvador, Estado de Bahia, Brazil, 41253-190
Actively Recruiting
96
Clinica Amo - Rio Vermelho
Salvador, Estado de Bahia, Brazil, 41950- 640
Actively Recruiting
97
Onco-Vida - Instituto Especializado De Oncologia
Brasília, Federal District, Brazil, 70390-150
Not Yet Recruiting
98
Hospital Erasto Gaertner
Curitiba, Paraná, Brazil, 81520-060
Actively Recruiting
99
Real Hospital Portugues
Recife, Pernambuco, Brazil, 52010-075
Actively Recruiting
100
Vencer Centro de Pesquisa LTDA
Teresina, Piauí, Brazil, 64049-200
Actively Recruiting
101
Liga Norte Riograndense Contra o Câncer
Natal, Rio Grande do Norte, Brazil, 59062-000
Actively Recruiting
102
ONCOSITE - Centro de Pesquisa Clinica em Oncologia
Ijuí, Rio Grande do Sul, Brazil, 98700-000
Actively Recruiting
103
Hospital Moinhos de Vento
Porto Alegre, Rio Grande do Sul, Brazil, 90560032
Not Yet Recruiting
104
Hospital São Lucas da PUCRS
Porto Alegre, Rio Grande do Sul, Brazil, 90610-000
Not Yet Recruiting
105
Fundação Pio XII - Hospital de Câncer de Barretos
Barretos, São Paulo, Brazil, 14784400
Actively Recruiting
106
Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo (USP)
Ribeirão Preto, São Paulo, Brazil, 14051-140
Actively Recruiting
107
Faculdade de Medicina do ABC
Santo André, São Paulo, Brazil, 09060-650
Not Yet Recruiting
108
Fundação Faculdade Regional de Medicina de São José do Rio Preto
São José do Rio Preto, São Paulo, Brazil, 15090000
Actively Recruiting
109
Hospital Alemao Oswaldo Cruz
São Paulo, São Paulo, Brazil, 01327-001
Actively Recruiting
110
Fundação Doutor Amaral Carvalho
Jaú, Brazil, 17210-080
Not Yet Recruiting
111
Icesp - Instituto Do Câncer Do Estado de São Paulo
São Paulo, Brazil, 01246-000
Not Yet Recruiting
112
MBAL Uni Hospital
Panagyurishte, Pazardzhik, Bulgaria, 4500
Actively Recruiting
113
Complex Oncology Center - Burgas
Burgas, Bulgaria, 8000
Actively Recruiting
114
Medical Center Futuremeds
Plovdiv, Bulgaria, 4000
Not Yet Recruiting
115
MHAT for Women's Health Nadezhda
Sofia, Bulgaria, 1330
Actively Recruiting
116
Acibadem City Clinic University Multiprofile Hospital for Active Treatment Tokuda EAD
Sofia, Bulgaria, 1407
Actively Recruiting
117
University Specialized Hospital for Active Treatment of Oncology EAD
Sofia, Bulgaria, 1756
Not Yet Recruiting
118
BC Cancer Abbotsford
Abbotsford British Columbia, British Columbia, Canada, V2S 0C2
Actively Recruiting
119
CIUSSS de l'Est-de-l'Île-de-Montréal
Montreal, Quebec, Canada, H1T 2M4
Actively Recruiting
120
Centre de Services Ambulatoire de St-Jerome
Saint-Jérôme, Quebec, Canada, J7Y 0L1
Actively Recruiting
121
Unité de Recherche Clinique du CISSS des Laurentides
Saint-Jérôme, Quebec, Canada, J7Z 2V4
Actively Recruiting
122
Clínica Alemana Valdivia
Valdivia, Los Ríos Region, Chile, 5090000
Actively Recruiting
123
Oncocentro Valdivia
Valdivia, Los Ríos Region, Chile, 5690000
Actively Recruiting
124
Iceg Clinic
La Florida, Santiago Metropolitan, Chile, 8241479
Actively Recruiting
125
Fundación Arturo Lopéz Pérez
Providencia, Santiago Metropolitan, Chile, 750000
Actively Recruiting
126
FALP
Providencia, Santiago Metropolitan, Chile, 7500836
Actively Recruiting
127
Fundacion Arturo Lopez Perez
Providencia, Santiago Metropolitan, Chile, 7500966
Actively Recruiting
128
Profar
Providencia, Santiago Metropolitan, Chile, 7501010
Actively Recruiting
129
FALP
Santiago, Santiago Metropolitan, Chile, 7500921
Actively Recruiting
130
Clínica Vespucio
Santiago, Santiago Metropolitan, Chile, 8241479
Actively Recruiting
131
Instituto Nacional del Cancer
Santiago, Santiago Metropolitan, Chile, 8380455
Actively Recruiting
132
Sociedad Oncovida SA
Santiago, Santiago Metropolitan, Chile, 8380456
Actively Recruiting
133
Oncocentro Apys
Viña del Mar, Valparaiso, Chile, 2520598
Actively Recruiting
134
Anhui Provincial Cancer Hospital
Hefei, Anhui, China, 230031
Not Yet Recruiting
135
Beijing Cancer hospital
Beijing, Beijing Municipality, China, 100142
Not Yet Recruiting
136
Beijing Chest Hospital,Capital Medical University
Beijing, Beijing Municipality, China, 101149
Actively Recruiting
137
Fujian Cancer Hospital
Fuzhou, Fujian, China, 350014
Not Yet Recruiting
138
Nanfang Hospital of Southern Medical University
Guangzhou, Guangdong, China, 510515
Not Yet Recruiting
139
Huizhou Central People's Hospital
Huizhou, Guangdong, China, 516001
Actively Recruiting
140
Guangxi Medical University Affiliated Tumor Hospital
Nanning, Guangxi, China
Actively Recruiting
141
Harbin Medical University Cancer Hospital
Harbin, Heilongjiang, China, 150081
Not Yet Recruiting
142
The First Affiliated Hospital of Henan University of Science &Technology
Luoyang, Henan, China, 471003
Not Yet Recruiting
143
Henan Cancer Hospital
Zhengzhou, Henan, China, 450008
Actively Recruiting
144
Wuhan Union Hospital Cancer Center
Wuhan, Hubei, China, 430048
Not Yet Recruiting
145
Hubei Cancer Hospital
Wuhan, Hubei, China, 430079
Not Yet Recruiting
146
Hunan Cancer Hospital
Changsha, Hunan, China, 410013
Not Yet Recruiting
147
The First People's Hospital of Changzhou
Changzhou, Jiangsu, China, 213003
Actively Recruiting
148
Jiangsu Province Hospital
Nanjing, Jiangsu, China, 210029
Not Yet Recruiting
149
The Affiliated Hospital of Xuzhou Medical College
Xuzhou, Jiangsu, China, 221006
Not Yet Recruiting
150
The First Affiliated Hospital of Nanchang University
Nanchang, Jiangxi, China, 330200
Actively Recruiting
151
Jilin Province Tumor Hospital
Changchun, Jilin, China, 130000
Not Yet Recruiting
152
The First Affiliated Hospital of Xi'an Jiaotong University
Xi'an, Shaanxi, China, 710061
Not Yet Recruiting
153
Jinan Central Hospital
Jinan, Shandong, China, 250013
Not Yet Recruiting
154
Shandong Cancer Hospital
Jinan, Shandong, China, 250117
Not Yet Recruiting
155
LinYi Cancer Hospital
Linyi, Shandong, China, 276001
Not Yet Recruiting
156
Shanghai Chest Hospital
Shanghai, Shanghai Municipality, China, 200030
Not Yet Recruiting
157
Fudan University Shanghai Cancer Center
Shanghai, Shanghai Municipality, China, 200032
Actively Recruiting
158
Sichuan Cancer hospital
Chengdu, Sichuan, China, 610041
Not Yet Recruiting
159
West China Hospital, Sichuan University
Chengdu, Sichuan, China, 610041
Not Yet Recruiting
160
Tianjin Medical University General Hospital
Tianjin, Tianjin Municipality, China, 300052
Not Yet Recruiting
161
Yunnan Province Cancer Hospital
Kunming, Yunnan, China, 650118
Not Yet Recruiting
162
Sir Run Run Shaw Hospital of Zhejiang University School of Medicine
Hangzhou, Zhejiang, China, 310016
Not Yet Recruiting
163
Taizhou Hospital of Zhejiang Province
Taizhou, Zhejiang, China, 317000
Actively Recruiting
164
The First Affiliated Hospital of Wenzhou Medical University
Wenzhou, Zhejiang, China, 325000
Actively Recruiting
165
Fakultni Thomayerova nemocnice
Prague, Praha 4, Czechia, 140 59
Actively Recruiting
166
Krajska nemocnice Liberec, a.s.
Liberec1, Czechia, 460 01
Actively Recruiting
167
Nemocnice AGEL Novy Jicin a.s.
Nový Jičín, Czechia, 741 01
Actively Recruiting
168
Fakultni nemocnice Olomouc
Olomouc, Czechia, 779 00
Actively Recruiting
169
Fakultni Nemocnice Motol a Homolka
Prague, Czechia, 150 00
Actively Recruiting
170
CHU Bordeaux Haut-Leveque
Pessac, Aquitaine, France, 33604
Actively Recruiting
171
Centre Hospitalier de Cornouaille Quimper - Concarneau
Quimper, Finistère, France, 29107
Actively Recruiting
172
CHU de Toulouse - Hopital Larrey
Toulouse, Haute-garonne, France, 31059
Actively Recruiting
173
Centre Hospitalier Universitaire de Rennes - Hôpital Pontchaillou
Rennes, Ille-et-vilaine, France, 35033
Actively Recruiting
174
Centre de Cancérologie du Grand Montpellier
Montpellier, Languedoc-roussillon, France, 34070
Actively Recruiting
175
Hôpital Nord Guillaume-et-René-Laennec / CHU de Nantes
Saint-Herblain, Loire-atlantique, France, 44800
Actively Recruiting
176
Institut de Cancérologie de l'Ouest
Saint-Herblain, Loire-atlantique, France, 44805
Actively Recruiting
177
Centre Hospitalier de Cholet
Cholet, PAYS de Loire, France, 49300
Actively Recruiting
178
Centre Hospitalier intercommunal de Toulon La Seyne sur Mer
Toulon, Provence-Alpes-Côte d'Azur Region, France, 83100
Actively Recruiting
179
Centre Hospitalier Intercommunal de Créteil
Créteil, Val-de-marne, France, 94010
Actively Recruiting
180
Assistance Publique Hôpitaux de Marseille - Hôpital Nord
Marseille, France, 13915
Actively Recruiting
181
Centre Antoine Lacassagne
Nice, France, 06189
Actively Recruiting
182
Hopitaux Universitaires Paris Centre-Hopital Cochin
Paris, France, 75014
Actively Recruiting
183
Institut Curie
Paris, France, 75248
Actively Recruiting
184
Johannes Apotheke Gröbenzell
Gröbenzell, Bavaria, Germany, 82194
Not Yet Recruiting
185
Klinikum Traunstein
Traunstein, Bavaria, Germany, 83278
Actively Recruiting
186
UKGM Gießen/Marburg
Giessen, Hesse, Germany, 35392
Actively Recruiting
187
Klinikum Kassel
Kassel, Hesse, Germany, 34125
Not Yet Recruiting
188
InVO Institut für Versorgungsforschung in der Onkologie
Koblenz, Rhineland-Palatinate, Germany, 56068
Actively Recruiting
189
Klinikum Chemnitz gGmbH
Chemnitz, Saxony, Germany, 09113
Actively Recruiting
190
Klinikum Chemnitz - Flemmingstraße
Chemnitz, Saxony, Germany, 09116
Actively Recruiting
191
ohO Research GmbH
Oldenburg in Holstein, Schleswig-Holstein, Germany, 23758
Actively Recruiting
192
Charité Campus Virchow-Klinikum
Berlin, Germany, 13353
Actively Recruiting
193
Labor Berlin
Berlin, Germany, 13353
Not Yet Recruiting
194
Vivantes Humboldt Klinikum Apotheke Nord
Berlin, Germany, 13509
Not Yet Recruiting
195
Vivantes Hospital Spandau
Berlin, Germany, 13585
Not Yet Recruiting
196
Asklepios Klinik Gauting GmbH
Gauting, Germany, 82131
Not Yet Recruiting
197
LungenClinic Grosshansdorf
Großhansdorf, Germany, 22927
Actively Recruiting
198
Radiologie München
München, Germany, 81377
Not Yet Recruiting
199
Thoracic General Hospital of Athens "I Sotiria"
Athens, Attikí, Greece, 115 27
Actively Recruiting
200
Metropolitan General Hospital
Athens, Attikí, Greece, 155 62
Actively Recruiting
201
Metropolitan Hospital
Athens, Attikí, Greece, 185 47
Actively Recruiting
202
Hygeia Hospital
Marousi, Attikí, Greece, 151 23
Actively Recruiting
203
European Interbalkan Medical Center
Thessaloniki, Thessaloníki, Greece, 570 01
Actively Recruiting
204
Errikos Dunant Hospital Center
Athens, Greece, 115 26
Actively Recruiting
205
University General Hospital of Larissa, Urology Department
Larissa, Greece, 41110
Actively Recruiting
206
Agios Loukas Clinic
Thessaloniki, Greece, 552 36
Actively Recruiting
207
Farkasgyepui Tudogyogyintezet
Farkasgyepű, Veszprém megye, Hungary, 8582
Not Yet Recruiting
208
Fejér Vármegyei Szent György Egyetemi Oktató Kórház
Székesfehérvár, Hungary, 8000
Not Yet Recruiting
209
Komárom-Esztergom Vármegyei Szent Borbála Kórház
Tatabánya, Hungary, 2800
Not Yet Recruiting
210
Spandana Oncology Centre (SOC)
Bengaluru, Karnataka, India, 560069
Actively Recruiting
211
Sahyadri Super Speciality Hospital
Pune, Maharashtra, India, 411004
Actively Recruiting
212
Bhakti Vedanta Hospital and Research Institute
Thane, Maharashtra, India, 401107
Actively Recruiting
213
Dr B. L. Kapur Memorial Hospital
New Delhi, National Capital Territory of Delhi, India, 110005
Actively Recruiting
214
Venkateshwar Hospital
New Delhi, National Capital Territory of Delhi, India, 110075
Actively Recruiting
215
Fortis Hospital
New Delhi, National Capital Territory of Delhi, India, 110088
Not Yet Recruiting
216
AIG Hospitals
Hyderabad, Telangana, India, 500032
Not Yet Recruiting
217
Shaare Zedek Medical Center
Jerusalem, Jerusalem, Israel, 9013102
Not Yet Recruiting
218
Clalit Health Services through Rabin Medical Center
Petah Tikva, Israel, 4941492
Actively Recruiting
219
Istituto Nazionale Tumori IRCCS Fondazione Pascale
Naples, Campania, Italy, 80131
Actively Recruiting
220
IRCCS - Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori"
Meldola, Emilia-Romagna, Italy, 47014
Actively Recruiting
221
Azienda Ospedaliero-Universitaria San Luigi Gonzaga
Orbassano, Piedmont, Italy, 10043
Actively Recruiting
222
Istituto Nazionale Tumori Regina Elena
Rome, ROMA, Italy, 00144
Actively Recruiting
223
Ospedale Isola Tiberina - Gemelli Isola
Rome, ROMA, Italy, 00186
Actively Recruiting
224
Policlinico "G. Rodolico"
Catania, Sicily, Italy, 95123
Actively Recruiting
225
Azienda Ospedaliera San Giuseppe Moscati
Avellino, Italy, 83100
Actively Recruiting
226
Ospedale San Raffaele
Milan, Italy, 20132
Actively Recruiting
227
Istituto Europeo di Oncologia IRCCS
Milan, Italy, 20141
Actively Recruiting
228
Istituto Oncologico Veneto IRCCS
Padova, Italy, 35128
Actively Recruiting
229
Ehime University Hospital
Tōon, Ehime, Japan, 791-0295
Not Yet Recruiting
230
Kurume University Hospital
Kurume, Fukuoka, Japan, 830-0011
Actively Recruiting
231
Gunma Prefectural Cancer Center
Otashi, Gunma, Japan, 373-8550
Not Yet Recruiting
232
National Hospital Organization Asahikawa Medical Center
Asahikawa, Hokkaido, Japan, 0708644
Actively Recruiting
233
Kobe City Medical Center General Hospital
Kobe, Hyōgo, Japan, 650-0047
Actively Recruiting
234
Kanagawa cancer center
Yokohama, Kanagawa, Japan, 2418515
Not Yet Recruiting
235
Mie Chuo Medical Center
Tsu, Mie-ken, Japan, 514-1101
Actively Recruiting
236
Sendai Kousei Hospital
Sendai, Miyagi, Japan, 9810914
Actively Recruiting
237
NHO Kinki Chuo Chest Medical Center
Sakai, Osaka, Japan, 591-8555
Not Yet Recruiting
238
The University of Osaka Hospital
Suita, Osaka, Japan, 565-0871
Not Yet Recruiting
239
Nippon Medical School Hospital
Bunkyo-ku, Tokyo, Japan, 113-8603
Not Yet Recruiting
240
National Cancer Center Hospital
Chuo-ku, Tokyo, Japan, 104-0045
Actively Recruiting
241
The Cancer Institute Hospital of JFCR
Koto, Tokyo, Japan, 135-8550
Actively Recruiting
242
National Hospital Organization Tokyo Medical Center
Meguro-Ku, Tokyo, Japan, 152-8902
Not Yet Recruiting
243
Yamagata University Hospital
Yamagata, Yamagata, Japan, 990-9585
Actively Recruiting
244
National Hospital Organization Kyushu Medical Center
Fukuoka, Japan, 810-8563
Actively Recruiting
245
National Hospital Organization Kyushu Cancer Center
Fukuoka, Japan, 811-1395
Actively Recruiting
246
National Hospital Organization Kyoto Medical Center
Kyoto, Japan, 612-8555
Actively Recruiting
247
National Hospital Organization Okayama Medical Center
Okayama, Japan, 701-1154
Actively Recruiting
248
Osaka International Cancer Institute
Osaka, Japan, 541-8567
Actively Recruiting
249
Clinica Integral Internacional de Oncología
Puebla City, Mexico, 72530
Actively Recruiting
250
Ziekenhuis St. Jansdal
Harderwijk, Gelderland, Netherlands, 3844 DG
Not Yet Recruiting
251
Amphia Ziekenhuis, locatie Breda Molengracht
Breda, North Brabant, Netherlands, 4818 CK
Not Yet Recruiting
252
Isala, locatie Zwolle
Zwolle, Overijssel, Netherlands, 8025 AB
Not Yet Recruiting
253
Frisius Medisch Centrum
Leeuwarden, Provincie Friesland, Netherlands, 8934 AD
Not Yet Recruiting
254
St. Antonius Ziekenhuis, locatie Utrecht
Utrecht, Netherlands, 3543 AZ
Not Yet Recruiting
255
Med-Polonia Sp. z o. o.
Poznan, Greater Poland Voivodeship, Poland, 60-693
Actively Recruiting
256
Instytut Genetyki i Immunologii GENIM
Lublin, Lublin Voivodeship, Poland, 20-609
Actively Recruiting
257
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy w Warszawie
Warsaw, Masovian Voivodeship, Poland, 02-781
Actively Recruiting
258
Uniwersyteckie Centrum Kliniczne
Gdansk, Poland, 80-214
Not Yet Recruiting
259
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie Panstwowy Instytut Badawczy
Gliwice, Poland, 44-102
Not Yet Recruiting
260
Wielkopolskie Centrum Pulmonologii i Torakochirurgii im. Eugenii i Janusza Zeylandow
Poznan, Poland, 60-569
Actively Recruiting
261
Instytut MSF Sp zoo
Lodz, Łódź Voivodeship, Poland, 90-302
Actively Recruiting
262
Institutul Oncologic Bucuresti "Prof. Dr. Alexandru Trestioreanu"
Bucharest, Bucharest, Romania, 022338
Not Yet Recruiting
263
SC Medisprof SRL
Cluj-Napoca, Cluj, Romania, 400641
Actively Recruiting
264
SC Radiotherapy Center Cluj SRL
Florești, Cluj, Romania, 407280
Actively Recruiting
265
Ovidius Clinical Hospital OCH
Ovidiu, Constanța County, Romania, 905900
Not Yet Recruiting
266
S C Oncocenter Oncologie Clinica S R L
Timișoara, Timiș County, Romania, 300166
Not Yet Recruiting
267
Univerzitná nemocnica Bratislava - Nemocnica Ružinov
Bratislava, Bratislava Region, Slovakia, 821 01
Actively Recruiting
268
Vychodoslovensky Onkologicky Ustav a.s.
Košice, Košice Region, Slovakia, 040 01
Actively Recruiting
269
Nemocnica AGEL Komarno
Komárno, Nitra Region, Slovakia, 945 05
Actively Recruiting
270
Fakultna nemocnica Trnava
Trnava, Trnava Region, Slovakia, 917 02
Actively Recruiting
271
Fakultna nemocnica s poliklinikou Nove Zamky
Nové Zámky, Slovakia, 94034
Actively Recruiting
272
POKO Poprad s.r.o.
Poprad, Slovakia, 058 01
Actively Recruiting
273
Chonnam National University Hwasun Hospital
Hwasun-gun, Jeonranamdo, South Korea, 58128
Actively Recruiting
274
Seoul National University Bundang Hospital
Seongnam, Kyǒnggi-do, South Korea, 13620
Actively Recruiting
275
The Catholic University Of Korea St. Vincent's Hospital
Suwon, Kyǒnggi-do, South Korea, 16247
Actively Recruiting
276
Ajou University Hospital
Suwon, Kyǒnggi-do, South Korea, 16499
Actively Recruiting
277
Pusan National University Hospital
Busan, Pusan-kwangyǒkshi, South Korea, 49241
Actively Recruiting
278
Inje University Haeundae Paik Hospital
Haeundae-gu, Pusan-kwangyǒkshi, South Korea, 48108
Actively Recruiting
279
Severance Hospital, Yonsei University Health System
Seoul, Seoul-teukbyeolsi [seoul], South Korea, 03722
Actively Recruiting
280
Boramae Medical Center
Seoul, Seoul-teukbyeolsi [seoul], South Korea, 07061
Actively Recruiting
281
Korea University Guro Hospital
Seoul, Seoul-teukbyeolsi [seoul], South Korea, 08308
Actively Recruiting
282
Kyungpook National University Chilgok Hospital
Deagu, Taegu-kwangyǒkshi, South Korea, 41404
Actively Recruiting
283
CHUAC-Complejo Hospitalario Universitario A Coruña
A Coruña, A Coruña [LA Coruña], Spain, 15006
Actively Recruiting
284
Hospital General Universitario de Elche
Elche, Alicante, Spain, 03203
Actively Recruiting
285
Hospital Universitari Dexeus
Barcelona, Barcelona [barcelona], Spain, 08028
Actively Recruiting
286
Hospital de la Santa Creu i Sant Pau
Barcelona, Catalunya [cataluña], Spain, 08041
Actively Recruiting
287
Institut Català d'Oncologia - L'Hospitalet
L'Hospitalet de Llobregat, Catalunya [cataluña], Spain, 08908
Actively Recruiting
288
Hospital Jerez de la Frontera
Jerez de la Frontera, Cádiz, Spain, 11407
Actively Recruiting
289
Hospital Son Llàtzer
Palma, Illes Balears [islas Baleares], Spain, 07198
Actively Recruiting
290
Hospital Universitario 12 de Octubre
Madrid, Madrid, Comunidad de, Spain, 28041
Actively Recruiting
291
Hospital Clinico de Valencia
Valencia, Valenciana, Comunitat, Spain, 46010
Actively Recruiting
292
Fundació Hospital Universitari Vall d'Hebron - Institut de Recerca (hereinafter, "VHIR")
Barcelona, Spain, 08035
Actively Recruiting
293
Fundación Privada Instituto de Investigación Oncológica de Vall Hebron (hereinafter, "VHIO"
Barcelona, Spain, 08035
Actively Recruiting
294
Hospital Universitari Vall D Hebron
Barcelona, Spain, 08035
Actively Recruiting
295
Hospital General Universitario Gregorio Marañon
Madrid, Spain, 28007
Actively Recruiting
296
Hospital Universitario Fundación Jiménez Díaz
Madrid, Spain, 28040
Actively Recruiting
297
Hospital Quirón Málaga
Málaga, Spain, 29004
Actively Recruiting
298
Hospital Universitario Virgen Del Rocio
Seville, Spain, 41013
Actively Recruiting
299
Inselspital Bern
Bern, Canton of Bern, Switzerland, 3010
Actively Recruiting
300
UniversitätsSpital Zürich
Zurich, Switzerland, 8091
Actively Recruiting
301
Chi Mei Hospital - Liouying Branch
Tainan, Tainan, Taiwan, 73657
Not Yet Recruiting
302
National Taiwan University Cancer Center (NTUCC)
Taipei City, Taipei, Taiwan, 106
Not Yet Recruiting
303
Kaohsiung Medical University Chung-Ho Memorial Hospital
Kaohsiung City, Taiwan, 807
Not Yet Recruiting
304
Chang Gung Memorial Hospital at Kaohsiung
Kaohsiung City, Taiwan, 833401
Not Yet Recruiting
305
Taichung Veterans General Hospital
Taichung, Taiwan, 407
Not Yet Recruiting
306
National Cheng Kung University Hospital
Tainan, Taiwan, 704
Actively Recruiting
307
National Taiwan University Hospital
Taipei, Taiwan, 10002
Not Yet Recruiting
308
Taipei Veterans General Hospital
Taipei, Taiwan, 11217
Actively Recruiting
309
Medipol Mega Universite Hastanesi
Istanbul, İ̇stanbul, Turkey (Türkiye), 34214
Actively Recruiting
310
İ.A.Ü VM Medical Park Florya Hastanesi
Istanbul, İ̇stanbul, Turkey (Türkiye), 34295
Actively Recruiting
311
TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi
Istanbul, İ̇stanbul, Turkey (Türkiye), 34722
Not Yet Recruiting
312
Ankara University Health Practice and Research Hospitals
Ankara, Turkey, Turkey (Türkiye), 06230
Actively Recruiting
313
Adana Medical Park Seyhan Hastanesi
Adana, Turkey (Türkiye), 01140
Actively Recruiting
314
Gulhane Egitim Arastirma Hastanesi
Ankara, Turkey (Türkiye), 06010
Actively Recruiting
315
Hacettepe Universite Hastaneleri
Ankara, Turkey (Türkiye), 06230
Actively Recruiting
316
Memorial Ankara Hastanesi
Ankara, Turkey (Türkiye), 06520
Actively Recruiting
317
Gazi University Health Research and Application Center Gazi Hospital
Ankara, Turkey (Türkiye), 06560
Actively Recruiting
318
Liv Hospital Ankara
Ankara, Turkey (Türkiye), 06680
Actively Recruiting
319
Ankara Bilkent Şehir Hastanesi
Ankara, Turkey (Türkiye), 06800
Actively Recruiting
320
Antalya Egitim ve Arastırma Hastanesi
Antalya, Turkey (Türkiye), 07100
Actively Recruiting
321
Dicle Üniversitesi
Diyarbakır, Turkey (Türkiye), 21200
Actively Recruiting
322
Istanbul Universitesi Cerrahpasa
İstanbul - Fatih, Turkey (Türkiye), 34098
Actively Recruiting
323
Royal Cornwall Hospitals NHS Trust
Truro, Carnwall, United Kingdom, TR1 3LJ
Actively Recruiting
324
Weston Park Hospital
Sheffield, England, United Kingdom, S10 2SJ
Not Yet Recruiting
325
Mount Vernon Hospital
Northwood, Hillingdon, United Kingdom, HA6 2RN
Not Yet Recruiting
326
St Bartholomew's Hospital
London, London, CITY of, United Kingdom, EC1A 7BE
Actively Recruiting
327
Musgrove Park Hospital
Taunton, Somerset, United Kingdom, TA1 5DA
Not Yet Recruiting
328
Ipswich Hospital
Ipswich, Suffolk, United Kingdom, IP4 5PD
Not Yet Recruiting
329
The Christie NHS Foundation Trust
Manchester, United Kingdom, M20 4BX
Actively Recruiting
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Research Team
P
Pfizer CT.gov Call Center
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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