Actively Recruiting
Enrichment of Lung Cancer Screening Through Unexplained Weight Loss to Improve Early Detection and Survival
Led by Memorial Sloan Kettering Cancer Center · Updated on 2026-01-23
409
Participants Needed
8
Research Sites
N/A
Total Duration
On this page
Sponsors
M
Memorial Sloan Kettering Cancer Center
Lead Sponsor
A
AstraZeneca
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are investigating whether people aged 50 to 80 who experience unexplained weight loss and undergo lung cancer screening are more likely to have or develop lung cancer than those without unexplained weight loss. The study focuses on using low-dose computed tomography (LDCT) scans, which produce detailed lung images with minimal radiation, to detect tumors. Additionally, researchers will analyze blood samples to explore the potential for blood tests to aid in diagnosing lung cancer. All participants will receive annual LDCT scans to monitor their lungs, with imaging performed at the start of the study and again after one year. At these same time points, blood samples will be collected for later analysis of circulating tumor DNA (ctDNA). Participants will also complete a screening questionnaire at baseline and one year after enrollment to collect relevant health information. Throughout the study, participants will be monitored for lung cancer incidence over two years. Researchers will evaluate the occurrence of lung cancer in those with unexplained weight loss. The study involves regular imaging, blood draws, and questionnaires to gather data. Participants are expected to comply with study procedures and will be followed to assess outcomes and safety during the study period.
CONDITIONS
Brief Title
A Study of Lung Cancer Screening in People With Unexplained Weight Loss
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 50 and 80 years old
- At least 20 pack-years history of smoking
- Unexplained weight loss of 3-10% within the past 18 months not due to an underlying medical condition
- Eligible for American Cancer Society lung cancer screening
- Life expectancy greater than 1 year as assessed by the treating clinician
You will not qualify if you...
- Currently pregnant or trying to become pregnant
- Chest CT scan (LDCT or standard) performed within the past 12 months
- Prior history of non-small cell lung cancer
- Undergoing or referred for diagnostic evaluation due to suspicion of malignancy
- Patients with germline pathogenic genetic variant who had whole body MRI within past 12 months
- Unable to comply with study procedures
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - 1 day
Participants undergo Low Dose CT imaging and blood draws at baseline to assess lung health and collect biospecimens.
1 visit (in-person) at baseline
Duration - 2 years
Participants are monitored with annual Low Dose CT imaging, blood draws, and screening questionnaires to detect lung cancer early.
1 visit (in-person) at Year 1
Trial Site Locations
Total: 8 locations
1
Memorial Sloan Kettering at Basking Ridge (All Protocol Activities)
Basking Ridge, New Jersey, United States, 07920
Actively Recruiting
2
Memorial Sloan Kettering Monmouth (All Protocol Activities)
Middletown, New Jersey, United States, 07748
Actively Recruiting
3
Memorial Sloan Kettering Bergen (All Protocol Activities)
Montvale, New Jersey, United States, 07645
Actively Recruiting
4
Memorial Sloan Kettering Suffolk-Commack (All Protocol Activities)
Commack, New York, United States, 11725
Actively Recruiting
5
Memorial Sloan Kettering Westchester (All Protocol Activities)
Harrison, New York, United States, 10604
Actively Recruiting
6
Memorial Sloan Kettering Cancer Center (All Protocol Activities)
New York, New York, United States, 10065
Actively Recruiting
7
Montefiore Health Systems (Montefiore Medical Center)
The Bronx, New York, United States, 10467
Actively Recruiting
8
Memorial Sloan Kettering Nassau (All Protocol Activities)
Uniondale, New York, United States, 11553
Actively Recruiting
Research Team
P
Puneeth Iyengar, MD, PhD
B
Bernard Park, MD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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