Long-Term Study Using Multimodal and Molecular Imaging to Understand and Diagnose Degenerative Dementia in Adults Aged 50 to 85

What this Trial Is About

Researchers are conducting a multicenter observational study to establish a long-term group of patients with Alzheimers disease and other dementias. This study uses neuroimaging, molecular imaging, biological markers, and digital markers to investigate dementia disease mechanisms, diagnosis, condition assessment, and prognosis. The study focuses on exploring new solutions to better understand and evaluate different dementia subtypes including Alzheimers disease, frontotemporal dementia, and dementia with Lewy bodies. The project collects multimodal MRI imaging data, various body fluid and digital markers, and uses advanced algorithms to analyze imaging features. Some participants also undergo special radionuclide imaging with new diagnostic probes to assess their potential for early Alzheimers diagnosis. Longitudinal follow-up of patients with mild cognitive impairment and amyloid positivity uses imaging fusion technology to study changes as they possibly progress to Alzheimers disease. Participants will undergo repeated evaluations including cognitive tests, MRI and PET scans, blood biomarker sampling, and assessments of daily living, speech, mood, and brain activity via EEG at baseline and annually for up to four years. Researchers will monitor changes in cognitive impairment incidence and various neurological and functional measures over time. The study includes informed consent and safety considerations such as MRI contraindications and cooperation with examinations.

Study on Multimodal Imaging and Molecular Imaging Techniques in Degenerative Dementia