Study of Platelet Population Changes Under Circulatory Support With ECMO

What this Trial Is About

Researchers are studying how different types of blood platelets change in adults receiving extracorporeal membrane oxygenation (ECMO) support, which is used for severe cardiac or respiratory failure. Advances in flow cytometry have shown four major platelet types with different functions, and changes in these types may relate to complications during ECMO treatment. This observational study aims to better understand these platelet population changes over time under ECMO support. The study observes adult patients treated with veno-arterial or veno-venous ECMO implanted within the previous 24 hours in intensive care units. There are no investigational treatments or interventions being administered; instead, platelet populations are monitored at specific time points after ECMO initiation, specifically on days 1, 3, and 7. This approach helps researchers document how platelet types shift during the first week of ECMO therapy. Participants will be involved in blood sample collections to assess platelet populations at the defined days after ECMO starts. These assessments involve flow cytometry techniques to measure the proportions of native, proaggregating, procoagulant, and apoptotic platelets. The primary outcome focuses on these proportional changes. The study is sponsored by University Hospital, Strasbourg, and participation lasts for the week following ECMO initiation, with no additional treatments provided as part of the study.

Study of Platelet Population Changes Under Circulatory Support With ECMO