Actively Recruiting
Cardiac Remodelling Following Endovascular Repair of the Aorta
Led by Lisbon Academic Medical Center - Centro Académico de Medicina de Lisboa · Updated on 2026-02-17
40
Participants Needed
2
Research Sites
52 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to evaluate the effects of endovascular aortic repair (EVAR) on heart structure and function in patients with aortic diseases such as degenerative aneurysms, penetrating ulcers, or intramural hematomas. The study focuses on how EVAR might influence cardiac remodeling by closely monitoring changes in heart measurements over time. It is an observational study conducted by the Lisbon Academic Medical Center. Participants who have undergone EVAR will receive detailed assessments before surgery and again at 6 and 12 months after the procedure. These evaluations include clinical exams, blood tests, CT scans, echocardiography, and cardiac magnetic resonance imaging to gather comprehensive data on heart morphology and function. The study will analyze how these heart measurements change following the intervention. During the study, participants will have their heart's left ventricular mass, volume, and strain measured and compared at baseline, 6 months, and 12 months. Researchers will also observe blood pressure trends as potential early indicators of heart changes after EVAR. This monitoring helps to understand the relationship between the repair's anatomical factors and cardiac remodeling. The total participation includes pre-surgery evaluation and follow-up visits at 6 and 12 months.
CONDITIONS
Brief Title
Cardiac Remodelling Following Endovascular Repair of the Aorta
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients over 18 years old
- Diagnosed with degenerative arch, descending thoracic or abdominal aortic aneurysms, penetrating aortic ulcers, or intramural hematomas
- Managed with total endovascular aortic repair (EVAR) in an elective setting
You will not qualify if you...
- Heart failure with ejection fraction less than 35 to 50% or New York Heart Association class III or IV
- Left ventricular wall motion abnormality
- Moderate to severe valve disease
- History of or expected cardiac/aortic surgery during the study
- Coronary artery disease
- Atrial fibrillation
- Congenital heart disease
- Connective tissue disorders
- Chronic kidney disease with eGFR less than 30 mL/min/173 m2
- Moderate to severe pulmonary disease with FEV1 less than 50% predicted or mMRC dyspnoea scale 3-4
- Contraindications to cardiac magnetic resonance (non-compatible pacemakers, metal implants, claustrophobia)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Within 1 month before surgery
Participants undergo pre-surgery evaluations including clinical evaluation, blood sampling, CT scan, echocardiography, and cardiac magnetic resonance to assess cardiac function before endovascular repair of the aorta.
1 visit (in-person)
Duration - 12 months
Participants are evaluated at 6 and 12 months post-surgery with clinical evaluation, blood sampling, CT scan, echocardiography, and cardiac magnetic resonance to monitor cardiac remodelling following endovascular repair.
2 visits (in-person) at 6 and 12 months post-surgery
Trial Site Locations
Total: 2 locations
1
Unidade Local de Saúde Santa Maria
Lisbon, Portugal, 1649-028
Actively Recruiting
2
Unidade Local de Saúde de Santa Maria, E.P.E.
Lisbon, Portugal
Not Yet Recruiting
Research Team
A
Augusto Ministro Augusto Ministro
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here