Study on Using Tumor Budding to Guide Surgery in Early-stage Oral Squamous Cell Carcinoma Comparing Surgery With or Without Neck Lymph Node Removal

What this Trial Is About

Oral squamous cell carcinoma is a common cancer in the mouth and face area that often spreads early to nearby lymph nodes. This research investigates if removing cervical lymph nodes is always necessary for early-stage cases or if it could sometimes be avoided. The study explores whether tumor budding can help guide personalized surgery plans to avoid unnecessary lymph node removal. Participants will be divided based on tumor budding levels into four groups. Some will have both the primary tumor removed and cervical lymph node dissection, while others will have only the primary tumor removed. This approach tests if tumor budding levels can help decide the best surgical treatment for early-stage oral squamous cell carcinoma. Participants will be followed for five years with regular check-ups every three months during the first year and every six months afterward. Researchers will assess survival rates, disease-free survival, recurrence rates, and quality of life. The study includes physical exams and MRI scans to monitor for cancer spread and overall health throughout the follow-up period.

A Study on Tumor Budding Guiding Individualized Surgical Planning of Early-stage Oral Squamous Cell Carcinoma.