Randomized Placebo-Controlled Trial of Ubiquinol for Fatigue and Muscle Strength in Adults Using GLP-1 Weight Loss Medications

What This Trial Is About

Researchers are evaluating whether taking a daily ubiquinol supplement can reduce fatigue and help maintain muscle strength in adults aged 30 to 65 who are using GLP-1 weight loss medications such as Wegovy4 or Mounjaro4. Ubiquinol is a natural form of Coenzyme Q10 that supports energy production in the body. The study aims to compare ubiquinol with a placebo to see if it helps reduce fatigue and support muscle strength during weight loss treatment. Participants will be randomly assigned to take either a 100 mg ubiquinol capsule or a placebo capsule daily for 9 months. The placebo looks similar to the active supplement and both are taken with the first meal of the day. The study is conducted fully remotely, with no clinic visits required. Nurses will visit participants homes four times during the study at months 0, 3, 6, and 9 to collect blood samples, measure body metrics, and supervise a sit-to-stand exercise test. Participants will also have monthly video calls with a dietitian and regularly log their diet and exercise using a smartphone app. Throughout the study, participants will complete questionnaires and track their diet and exercise habits. Researchers will measure self-reported fatigue after 9 months as the primary outcome. Secondary outcomes include quality of life, muscle function, body mass, and various blood markers such as Coenzyme Q10, vitamin levels, cholesterol, and blood sugar control. The study will last 9 months of active participation, with ongoing monitoring through remote visits and app-based data collection.

A Study on Ubiquinol on Fatigue and Muscle Strength in Healthy Adults Taking GLP-1 Agonists