Actively Recruiting
SuperSaturated Oxygen Comprehensive Observational Registry
Led by TherOx · Updated on 2026-04-24
1000
Participants Needed
24
Research Sites
241 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The SuperSaturated Oxygen Comprehensive Observational Registry (SSCORE) registry, a prospectively designed observational study, aims to evaluate the clinical utility and effectiveness of SuperSaturated Oxygen (SSO2) Therapy versus percutaneous coronary intervention (PCI) alone among patients with anterior acute myocardial infarction (AMI) in routine clinical practice. The goal is to collect real-world data from patients treated with SSO2 Therapy to determine its impact on the overall heart failure (HF) burden on patients and healthcare systems compared with usual care for treatment of patients with AMI. The SSCORE Registry will generate effectiveness and healthcare resource utilization data that will be used in cost-effectiveness analysis modeling.
CONDITIONS
Official Title
SuperSaturated Oxygen Comprehensive Observational Registry
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Men or women aged 18 years or older
- Presentation with acute myocardial infarction (AMI) and successful revascularization of the infarct-related artery with PCI
- Provided written informed consent approved by the Institutional Review Board
- Primary culprit lesion in the left anterior descending (LAD) coronary tree (for Prospective Control and SSO2 Treated On-Label Cohorts)
- Successful primary PCI within 6 hours of symptom onset with less than 50% residual stenosis and TIMI Grades 2 or 3 flow
- No major complications such as perforation, serious bleeding, or cardiogenic shock
- Not pregnant or nursing
You will not qualify if you...
- Life expectancy less than 2 years
- No access to medical records from the index hospitalization or outpatient visits
- Currently participating in another investigational drug or device trial
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 24 locations
1
MemorialCare Orange Coast Medical Center
Fountain Valley, California, United States, 92708
Actively Recruiting
2
UCSD Health La Jolla - Sulpizio Cardiovascular Center
La Jolla, California, United States, 92037
Actively Recruiting
3
MemorialCare Saddleback Medical Center
Laguna Hills, California, United States, 92653
Actively Recruiting
4
MemorialCare Long Beach Medical Center
Long Beach, California, United States, 90806
Actively Recruiting
5
Ronald Reagan UCLA Medical Center
Los Angeles, California, United States, 90095
Actively Recruiting
6
UCSD Hillcrest Medical Center
San Diego, California, United States, 92103
Actively Recruiting
7
Baptist Health Baptist Hospital
Miami, Florida, United States, 33176
Actively Recruiting
8
NCH Baker Hospital
Naples, Florida, United States, 34102
Actively Recruiting
9
NCH North Naples
Naples, Florida, United States, 34110
Actively Recruiting
10
University of Chicago
Chicago, Illinois, United States, 60637
Actively Recruiting
11
Carle Health Methodist Hospital
Peoria, Illinois, United States, 61636
Actively Recruiting
12
Ascension Via Christi St Francis
Wichita, Kansas, United States, 67214
Actively Recruiting
13
Corewell Health Dearborn Hospital
Dearborn, Michigan, United States, 48124
Actively Recruiting
14
Mercy Hospital
Coon Rapids, Minnesota, United States, 55433
Actively Recruiting
15
Abbott Northwestern Hospital
Minneapolis, Minnesota, United States, 55407
Actively Recruiting
16
United Hospital
Saint Paul, Minnesota, United States, 55102
Actively Recruiting
17
RWJ- Jersey City Medical Center
Jersey City, New Jersey, United States, 07302
Actively Recruiting
18
Robert Wood Johnson University Hospital
New Brunswick, New Jersey, United States, 08901
Actively Recruiting
19
Newark Beth Israel Medical Center
Newark, New Jersey, United States, 07112
Actively Recruiting
20
North Shore University Hospital
Manhasset, New York, United States, 11030
Actively Recruiting
21
Long Island Jewish Hospital
Queens, New York, United States, 11040
Actively Recruiting
22
Charleston Area Medical Center
Charleston, West Virginia, United States, 25304
Actively Recruiting
23
St Mary's Medical Center
Huntington, West Virginia, United States, 25702
Actively Recruiting
24
Aurora St Luke's Medical Center
Milwaukee, Wisconsin, United States, 53215
Actively Recruiting
Research Team
J
Jennifer Gardner
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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