Actively Recruiting

Phase Not Applicable
Age: 55Years - 70Years
All Genders
Healthy Volunteers
NCT07171190

Targeted Abdominal CT in Conjunction With Lung Cancer Screening

Led by University of Cambridge · Updated on 2025-12-19

6272

Participants Needed

1

Research Sites

98 weeks

Total Duration

On this page

Sponsors

U

University of Cambridge

Lead Sponsor

H

Hull University Teaching Hospitals NHS Trust

Collaborating Sponsor

AI-Summary

What this Trial Is About

Early detection through screening can improve cancer survival by identifying it when it's most treatable. The NHS now offers Lung Cancer Screening (LCS) assessments to people aged 55-74 who have ever smoked. Those at higher risk of lung cancer are offered a lung scan. This group also has a high risk of developing abdominal cancers, such as kidney cancer. A recent study explored whether it would be feasible to extend the lung scan to include the abdomen. Results showed most participants supported this addition, and the number of serious findings was similar to those detected in UK breast or bowel cancer screening programmes. However, the abdominal scan was only offered on the day of the lung scan, giving little time for people to consider their decision. The process also added too much time to be practical for widespread implementation. This new study will: * Test whether mentioning the possible abdominal scan in the initial LCS invitation affects participation in LCS assessments. * Test new processes to assess if the abdominal scan can be added to the lung scan with minimal extra time. * Check if participants can be split between the lung scan only group and lung and abdominal scan group using an approach called 'cluster randomisation'. This will be important in case a bigger trial is needed. * See whether the additional processes are acceptable People aged 55-70 who are invited to the lung cancer screening will be eligible to take part in this study. Only those who are found to be at a high risk of lung cancer after their assessment, and therefore offered a lung scan, will be offered the abdominal scan, provided they have not had an abdominal scan in the previous 12 months or one booked in the next 3 months. This study will take place in two existing lung cancer screening locations in Yorkshire.

CONDITIONS

Official Title

Targeted Abdominal CT in Conjunction With Lung Cancer Screening

Who Can Participate

Age: 55Years - 70Years
All Genders
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  • Be eligible for the first round of lung cancer screening in specified Yorkshire and North Yorkshire areas as a smoker or ex-smoker
  • Be registered with a GP in England
  • Be aged between 55 and 70 years 364 days at invitation
  • Have been randomized to receive an invitation mentioning the possible abdominal scan and booked a lung cancer screening assessment
  • Be at high risk for lung cancer based on PLCOM2012 or Liverpool Lung Project risk models
  • Have attended the lung scan appointment
  • Have provided written or electronic consent to participate
Not Eligible

You will not qualify if you...

  • Unable to give informed consent
  • Weight or size exceeds scanner limits (over 200 kg)
  • Unable to lie flat
  • Poor physical fitness making curative treatment unsuitable
  • Had a full lung CT scan meeting program standards within the last 12 months, with appointment deferred beyond study timeframe
  • Had an abdominal CT scan in the previous 12 months or has one booked within the next 3 months

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Trial Site Locations

Total: 1 location

1

Hull Teaching Hospitals Trust

Hull, United Kingdom, HU3 2JZ

Actively Recruiting

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Research Team

G

Grant Stewart

CONTACT

J

Jessica Kitt

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

SINGLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

SCREENING

Number of Arms

4

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