Actively Recruiting
Targeting Collagen VII Antibodies With IV IgG in Dystrophic Epidermolysis Bullosa
Led by M. Peter Marinkovich · Updated on 2026-05-05
8
Participants Needed
1
Research Sites
82 weeks
Total Duration
On this page
Sponsors
M
M. Peter Marinkovich
Lead Sponsor
E
Epidermolysis Bullosa Research Partnership
Collaborating Sponsor
AI-Summary
What this Trial Is About
The study objective is to see if IV IgG treatment in Recessive Dystrophic Epidermolysis Bullosa (RDEB) skin in conjunction with VYJUVEK treatment improves wound healing and affects the levels of C7 and HSV-1 antibody levels in serum. Fewer wounds, more rapidly healing wounds, and decreased C7 and HSV-1 antibodies could improve quality of life.
CONDITIONS
Official Title
Targeting Collagen VII Antibodies With IV IgG in Dystrophic Epidermolysis Bullosa
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of generalized Recessive dystrophic epidermolysis bullosa (RDEB) confirmed by COL7A1 mutations
- Diagnosis of Epidermolysis Bullosa Acquisita (EBA) with serum C7 antibody levels above normal range
- Baseline skin blistering greater than 5% of total body surface area
- At least one wound 20 cm² or larger that can be treated entirely with VYJUVEK weekly
- At least one wound 20 cm² or larger that has never been treated with VYJUVEK
- Ongoing VYJUVEK treatment
You will not qualify if you...
- History of blood clotting events (thrombotic events)
- History of heart failure
- History of kidney failure
- IgA deficiency
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Stanford University
Redwood City, California, United States, 94163
Actively Recruiting
Research Team
K
Kunju Clinical Research Coordinator, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here