Study to Determine Normal PSA Levels in Transgender Women and Non-binary People with Prostates Aged 40 and Older

What this Trial Is About

Prostate specific antigen PSA blood tests help diagnose prostate problems, including cancer. This research focuses on understanding normal PSA levels in transgender women and non-binary people who have prostates. Since hormonal treatments and surgeries can affect PSA levels, this study aims to fill a knowledge gap to improve prostate cancer detection in these groups. The study will involve 500 transgender women and non-binary participants aged 40 or older who have prostates and are undergoing hormone therapy or have had related surgery. Participants will have their PSA levels measured at the start and again six months later. If a high PSA level is found, further testing may be recommended. Participants will provide blood samples and share health information during the study. The main measurement is PSA concentration six months after enrollment. Researchers will monitor prostate cancer occurrence during this time. The study lasts for about six months after enrollment, with a follow-up call to check health status.

Trans and Non-binary Prostate-Specific Antigen Reference Interval Determination Study