Effects of reduced sodium intake on hypertension control in older individuals: results from the Trial of Nonpharmacologic Interventions in the Elderly (TONE).
L J Appel, M A Espeland, L Easter...
https://pubmed.ncbi.nlm.nih.gov/11231700/Completed
Led by National Heart, Lung, and Blood Institute (NHLBI) · Updated on 2016-11-07
N/A
Participants Needed
4
Research Sites
N/A
Total Duration
To test the efficacy of weight loss and sodium restriction, alone and combined, in maintaining the normotensive state following withdrawal of antihypertensive medications in an elderly cohort. Conducted in collaboration with the National Institute on Aging.
CONDITIONS
Trial of Nonpharmacologic Interventions in Elderly (TONE)
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National Heart, Lung, and Blood Institute (NHLBI)
Lead Sponsor
National Institute on Aging (NIA)
Collaborating Sponsor
Men and women with a systolic blood pressure of less than 145 mm Hg and diastolic blood pressure of less than 85 mm Hg on single-drug therapy.
Study Type
INTERVENTIONAL
Masking
N/A
Allocation
RANDOMIZED
Model
FACTORIAL
Primary Purpose
TREATMENT
Number of Arms
0
L J Appel, M A Espeland, L Easter...
https://pubmed.ncbi.nlm.nih.gov/11231700/L J Appel, M Espeland, P K Whelton...
https://pubmed.ncbi.nlm.nih.gov/7795830/J B Kostis, M A Espeland, L Appel...
https://pubmed.ncbi.nlm.nih.gov/9874055/M Kyla Shea, Barbara J Nicklas, Denise K Houston...
https://pubmed.ncbi.nlm.nih.gov/21775558/John B Kostis, Alan C Wilson, W Craig Hooper...
https://pubmed.ncbi.nlm.nih.gov/12360157/P K Whelton, L J Appel, M A Espeland...
https://pubmed.ncbi.nlm.nih.gov/9515998/Shiriki K Kumanyika, Mark A Espeland, Judy L Bahnson...
https://pubmed.ncbi.nlm.nih.gov/11836455/Liwei Chen, Zhenzhen Zhang, Wen Chen...
https://pubmed.ncbi.nlm.nih.gov/27077348/P K Whelton, J Babnson, L J Appel...
https://pubmed.ncbi.nlm.nih.gov/9033517/M A Espeland, S Kumanyika, J B Kostis...
https://pubmed.ncbi.nlm.nih.gov/8855996/National Heart, Lung, and Blood Institute (NHLBI)
Lead Sponsor
National Institute on Aging (NIA)
Collaborating Sponsor