Actively Recruiting

Age: 18Years +
All Genders
NCT07279402

TRIMPACT: Real-World First-Line Atezolizumab Use in Stage IV NSCLC With PD-L1 ≥50%

Led by Antalya Training and Research Hospital · Updated on 2026-04-30

150

Participants Needed

25

Research Sites

106 weeks

Total Duration

On this page

Sponsors

A

Antalya Training and Research Hospital

Lead Sponsor

H

Hoffmann-La Roche

Collaborating Sponsor

AI-Summary

What this Trial Is About

This prospective, multicenter, real-world observational study aims to evaluate the clinical outcomes of first-line atezolizumab monotherapy in patients with stage IV non-small cell lung cancer (NSCLC) with PD-L1 tumor cell expression ≥50% and no targetable mutations. The study aim to determine how atezolizumab performs in routine clinical practice with respect to survival, treatment response, and safety outcomes in this patient population in Türkiye.

CONDITIONS

Official Title

TRIMPACT: Real-World First-Line Atezolizumab Use in Stage IV NSCLC With PD-L1 ≥50%

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Signed informed consent form
  • Diagnosis of stage IV non-small cell lung cancer
  • Male or female patients aged 18 years or older
  • Patients prescribed atezolizumab according to routine clinical practice and approved indication in Trkiye
  • Patients who have received up to 3 cycles of atezolizumab at screening visit
Not Eligible

You will not qualify if you...

  • Patients not receiving atezolizumab for lung cancer according to standard care and approved indication
  • Known or suspected hypersensitivity to atezolizumab
  • Pregnant or breastfeeding women

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 25 locations

1

Adana City Hospital

Adana, Turkey (Türkiye)

Actively Recruiting

2

Afyonkarahisar Health Sciences University Hospital

Afyonkarahisar, Turkey (Türkiye), 03100

Actively Recruiting

3

Ankara Oncology Training and Research Hospital

Ankara, Turkey (Türkiye), 06200

Not Yet Recruiting

4

Memorial Ankara Hospital

Ankara, Turkey (Türkiye), 06560

Not Yet Recruiting

5

Ankara Bilkent City Hospital

Ankara, Turkey (Türkiye), 06800

Not Yet Recruiting

6

Ankara Atatürk Sanatoryum Training and Research Hospital

Ankara, Turkey (Türkiye)

Actively Recruiting

7

Antalya Training and Research Hospital

Antalya, Turkey (Türkiye), 07100

Actively Recruiting

8

Antalya City Hospital

Antalya, Turkey (Türkiye)

Actively Recruiting

9

Adnan Menderes University Faculty of Medicine Hospital

Aydin, Turkey (Türkiye), 09100

Actively Recruiting

10

Dicle University Hospital

Diyarbakır, Turkey (Türkiye), 21280

Not Yet Recruiting

11

Trakya University Faculty of Medicine Hospital

Edirne, Turkey (Türkiye), 22030

Actively Recruiting

12

Gaziantep City Hospital

Gaziantep, Turkey (Türkiye)

Actively Recruiting

13

Bahçelievler Memorial Hospital

Istanbul, Turkey (Türkiye), 34180

Not Yet Recruiting

14

İstanbul Medipol Mega Hospital

Istanbul, Turkey (Türkiye), 34214

Not Yet Recruiting

15

Ümraniye Training and Research Hospital

Istanbul, Turkey (Türkiye), 34766

Not Yet Recruiting

16

Marmara Üniversitesi Pendik Eğitim ve Araştırma Hastanesi

Istanbul, Turkey (Türkiye), 34899

Not Yet Recruiting

17

Başakşehir Çam and Sakura City Hospital

Istanbul, Turkey (Türkiye)

Actively Recruiting

18

Dokuz Eylul University Faculty of Medicine Hospital

Izmir, Turkey (Türkiye), 35340

Actively Recruiting

19

Ege University Hospital

Izmir, Turkey (Türkiye)

Actively Recruiting

20

Necmettin Erbakan University Meram Faculty of Medicine Hospital

Konya, Turkey (Türkiye), 42080

Actively Recruiting

21

Mersin University Faculty of Medicine Hospital

Mersin, Turkey (Türkiye), 33110

Actively Recruiting

22

Ordu State Hospital

Ordu, Turkey (Türkiye), 52200

Not Yet Recruiting

23

Sakarya University Faculty of Medicine Hospital

Sakarya, Turkey (Türkiye), 54050

Actively Recruiting

24

Medical Park Samsun Hospital

Samsun, Turkey (Türkiye), 55080

Not Yet Recruiting

25

Karadeniz Technical University Farabi Hospital

Trabzon, Turkey (Türkiye), 61080

Actively Recruiting

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Research Team

D

Derya Kıvrak Salim

CONTACT

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

1

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TRIMPACT: Real-World First-Line Atezolizumab Use in Stage IV NSCLC With PD-L1 ≥50% | DecenTrialz