Actively Recruiting
TUBectomy With Delayed Oophorectomy in High Risk Women to Assess the Safety of Prevention
Led by University Medical Center Nijmegen · Updated on 2026-04-06
3000
Participants Needed
66
Research Sites
1041 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The aim of the project is to evaluate the risk-reducing salpingectomy with delayed oophorectomy as an alternative for risk-reducing salpingo-oophorectomy in high risk women with respect to ovarian cancer incidence.
CONDITIONS
Official Title
TUBectomy With Delayed Oophorectomy in High Risk Women to Assess the Safety of Prevention
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Women with a confirmed pathogenic BRCA1, BRCA2, RAD51C, RAD51D, or BRIP1 germline mutation
- Age 25 to 40 years for BRCA1 carriers
- Age 25 to 45 years for BRCA2 carriers
- Age 25 to 50 years for RAD51C, RAD51D, or BRIP1 carriers
- Completed childbearing
- Presence of at least one fallopian tube
- Personal history of non-ovarian cancer allowed
- Provided informed consent according to regulations
You will not qualify if you...
- Postmenopausal status (natural or treatment-induced)
- Planning risk-reducing oophorectomy within two years after salpingectomy
- Legally incapable of giving consent
- Prior removal of both fallopian tubes
- Personal history of ovarian, fallopian tube, or peritoneal cancer
- Current diagnosis or treatment for any malignant disease
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 66 locations
1
UChicago Medicine
Chicago, Illinois, United States, 60637
Actively Recruiting
2
Dana Farber Cancer Institute
Boston, Massachusetts, United States, 02215
Actively Recruiting
3
Mayo Clinic
Rochester, Minnesota, United States, 55905
Actively Recruiting
4
Washington University Medical Center
St Louis, Missouri, United States, 63110
Actively Recruiting
5
Mount Sinai Hospital
New York, New York, United States, 10029
Actively Recruiting
6
Memorial Sloan Kettering Cancer Center
New York, New York, United States, 10065
Actively Recruiting
7
Duke University Hospital
Durham, North Carolina, United States, 27705
Actively Recruiting
8
Hospital of the University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104
Actively Recruiting
9
Harris Health Lyndon B. Johnson Hospital
Houston, Texas, United States, 77026
Actively Recruiting
10
MD Anderson Cancer Centre
Houston, Texas, United States, 77030-4009
Actively Recruiting
11
University of Washington
Seattle, Washington, United States, 98195
Actively Recruiting
12
Chris O'Brien Lifehouse
Sydney, New South Wales, Australia, 2050
Actively Recruiting
13
Westmead hospital
Sydney, New South Wales, Australia, 2145
Actively Recruiting
14
St Andrew War Memorial Hospital
Brisbane, Queensland, Australia, 4001
Actively Recruiting
15
Royal Brisbane Hospital
Brisbane, Queensland, Australia, 4006
Actively Recruiting
16
Greenslopes Private Hospital
Brisbane, Queensland, Australia, 4120
Actively Recruiting
17
Royal Adelaide Hospital
Adelaide, South Australia, Australia, 5000
Actively Recruiting
18
Frances Perry House
Melbourne, Victoria, Australia, 3050
Actively Recruiting
19
Mercy Hospital
Melbourne, Victoria, Australia, 3084
Actively Recruiting
20
Epworth Hospital
Richmon, Victoria, Australia, 3121
Actively Recruiting
21
Western Health
St Albans, Victoria, Australia, 3021
Actively Recruiting
22
King Edward Memorial Hospital
Perth, Western Australia, Australia, 6008
Actively Recruiting
23
The Mater Hospital
Brisbane, Australia
Actively Recruiting
24
Monash Health
Melbourne, Australia
Actively Recruiting
25
Peter MacCallum Centre
Melbourne, Australia
Actively Recruiting
26
Royal Womens Hospital
Melbourne, Australia
Actively Recruiting
27
Medical University of Graz
Graz, Austria
Actively Recruiting
28
Hopital Universitaire Bruxelles
Brussels, Belgium
Actively Recruiting
29
Universitair Ziekenhuis Leuven
Leuven, Belgium
Actively Recruiting
30
AC Camargo Cancer Centre
São Paulo, Brazil
Actively Recruiting
31
Vancouver General Hospital
Vancouver, Canada
Actively Recruiting
32
Klinikum St. Marien Amberg
Amberg, Germany
Not Yet Recruiting
33
Evangelische Waldkrankenhaus Spandau Berlin
Berlin-Spandau, Germany
Actively Recruiting
34
Klinikum Lippe Detmold
Detmold, Germany
Not Yet Recruiting
35
Evang. Kliniken Essen-Mitte
Essen, Germany
Actively Recruiting
36
Cork University Hospital
Cork, Ireland
Actively Recruiting
37
Universita di Bologna
Bologna, Italy
Actively Recruiting
38
Humanitas San Pio X
Milan, Italy
Actively Recruiting
39
San Gerardo Hospital
Monza, Italy
Actively Recruiting
40
Gemelli Hospital
Rome, Italy
Actively Recruiting
41
Instituto Nacional de Cancerología
Mexico City, Mexico
Actively Recruiting
42
Radboudumc
Nijmegen, Gelderland, Netherlands
Actively Recruiting
43
Maastricht University Medical Center
Maastricht, Limburg, Netherlands
Actively Recruiting
44
Catharina Ziekenhuis
Eindhoven, North Brabant, Netherlands, 5623 EJ
Actively Recruiting
45
Elisabeth-TweeSteden Ziekenhuis
Tilburg, North Brabant, Netherlands
Actively Recruiting
46
Amsterdam University Medical Center
Amsterdam, Netherlands
Actively Recruiting
47
Antoni van Leeuwenhoek
Amsterdam, Netherlands
Actively Recruiting
48
Amphia
Breda, Netherlands
Actively Recruiting
49
Medisch Spectrum Twente
Enschede, Netherlands
Actively Recruiting
50
University Medical Center Groningen
Groningen, Netherlands
Actively Recruiting
51
Medical Center Leeuwarden
Leeuwarden, Netherlands
Actively Recruiting
52
Leiden University Medical Center
Leiden, Netherlands
Actively Recruiting
53
Erasmus Medical Center
Rotterdam, Netherlands
Actively Recruiting
54
University Medical Center Utrecht
Utrecht, Netherlands
Actively Recruiting
55
Maxima Medical Center
Veldhoven, Netherlands
Actively Recruiting
56
Isala Klinieken
Zwolle, Netherlands
Actively Recruiting
57
Akershus University Hospital
Nordbyhagen, Norway
Active, Not Recruiting
58
Oslo University Hospital
Oslo, Norway
Actively Recruiting
59
Stavanger Uniersity Hospital
Stavanger, Norway
Actively Recruiting
60
Gdynia Oncology Centre
Gdynia, Poland
Actively Recruiting
61
Bonifraterskie Centrum Medyczne
Katowice, Poland
Actively Recruiting
62
Medical University of Silesia
Katowice, Poland
Actively Recruiting
63
National Cancer Institute Warsaw
Warsaw, Poland
Actively Recruiting
64
Vall D'Hebron Barcelona
Barcelona, Spain
Actively Recruiting
65
Karolinksa Institutet
Stockholm, Sweden
Actively Recruiting
66
Hospital Británico
Montevideo, Uruguay
Actively Recruiting
Research Team
J
Joanne A. de Hullu, MD, PhD
CONTACT
K
Karen H. Lu, MD, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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