Actively Recruiting
Ultra Sound Guided Genicular Nerves Cooled Radiofrequency Ablation in Total Knee Replacement Surgeries
Led by Ain Shams University · Updated on 2025-02-24
66
Participants Needed
1
Research Sites
8 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to evaluate the effectiveness of genicular nerves cooled radiofrequency ablation guided by ultrasound in improving rehabilitation quality for patients undergoing total knee replacement surgery due to osteoarthritis of the knee. Total knee replacement is a common surgery for patients experiencing persistent pain and limited movement, but post-operative pain can still significantly affect recovery, hospital stay, lifestyle, and patient satisfaction. The study seeks to explore new approaches to enhance the multimodal management plan for these patients. Participants in the study will be randomly assigned to one of three groups receiving different anesthesia and nerve ablation treatments. One group will receive epidural anesthesia during surgery. The second group will receive lumbar epidural anesthesia combined with unilateral genicular nerve cooled radiofrequency ablation before surgery. The third group will receive lumbar epidural anesthesia combined with bilateral genicular nerve cooled radiofrequency ablation before surgery. These procedures are designed to assess the impact on pain management and rehabilitation. During the study, participants will be closely monitored for pain control, with the primary outcome measure being the need for epidural rescue doses within the first 48 hours after surgery. Researchers will also evaluate the overall quality of rehabilitation following the nerve ablation procedures. The study includes assessments during and after surgery to understand how these interventions affect patient recovery and satisfaction. The study is sponsored by Ain Shams University and is expected to run until mid-2025.
CONDITIONS
Brief Title
Ultra Sound Guided Genicular Nerves Cooled Radiofrequency Ablation in Total Knee Replacement Surgeries
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Undergoing a scheduled unilateral total knee replacement surgery
You will not qualify if you...
- Allergy to any of the drugs used in the study
- Alcohol or drug abuse
- Psychiatric disease
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Day of surgery
Participants receive lumbar epidural anesthesia during surgery and may receive unilateral or bilateral genicular nerve cooled radiofrequency ablation pre-operatively.
1 pre-operative visit and 1 intra-operative procedure
Duration - 48 hours post-surgery
Participants receive epidural analgesia and are monitored for pain management and recovery after surgery.
Visits during the first 48 hours post-operative
Trial Site Locations
Total: 1 location
1
faculty of medicine Ain Shams University
Cairo, Egypt, 02
Actively Recruiting
Research Team
A
Abdallah soudi, M.D.
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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