Actively Recruiting
Understanding Immunity to the Flu Vaccine in COVID-19 Patients
Led by Stanford University · Updated on 2026-03-18
230
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
S
Stanford University
Lead Sponsor
N
National Institute of Allergy and Infectious Diseases (NIAID)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are studying how immunity to the flu vaccine changes over time in people who have had COVID-19, including those with other health conditions like obesity, type 2 diabetes, chronic fatigue, or long-term COVID-19 symptoms. This study includes children and adults aged 9 to 64, comparing those who had COVID-19 with those who did not. The goal is to better understand how prior COVID-19 infection affects flu vaccine response. All participants will receive one flu shot during the study. The study groups include people who have had COVID-19 and a control group without COVID-19. The flu vaccine is given once, and the immune response will be tracked over time. The study is observational and led by Stanford University. Participants will be monitored at one week and one month after vaccination to test their immune response to the flu vaccine. Assessments may include blood tests to measure immunity. The study involves several visits for these tests, and participants will be observed throughout the study period, which runs until April 2028. The study aims to collect detailed information on how immunity develops and changes after flu vaccination in people with different health backgrounds.
CONDITIONS
Brief Title
Understanding Immunity to the Flu Vaccine in COVID-19 Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 9 through 64 years
- Diagnosed with COVID-19 at least 2 months prior enrollment
- Patients with or without obesity, diabetes, chronic fatigue and/or long term COVID-19 symptoms
- Patients without COVID-19 diagnosis for controls
You will not qualify if you...
- Received the influenza vaccine less than 4 months ago
- Pregnant or lactating
- Patients with special risks attendant to venipuncture
- Use of immunomodulatory medications that may impact vaccine immune response per clinician's judgment
- Contraindication to the flu vaccine
- Immunodeficiency or autoimmune disease that may impact vaccine immune responses per clinician's judgement
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - 1 month
Participants receive a single flu vaccine shot to study immunity response.
1 visit (in-person) at vaccination and 2 follow-up visits for immunity testing at 1 week and 1 month
Trial Site Locations
Total: 1 location
1
Stanford University
Palo Alto, California, United States, 94304
Actively Recruiting
Research Team
S
SNP Center Inquiry
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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