Actively Recruiting
The Utility of Thromboelastography for Predicting the Risk of Coagulation-Related Damages Secondary to Traumatic Brain Injury
Led by Shanghai 6th People's Hospital · Updated on 2025-03-17
500
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating how hemocoagulation disorders affect patients with traumatic brain injury (TBI). This study focuses on the use of thromboelastography, a test to evaluate blood clotting, to determine whether posttraumatic coagulation problems lead to additional damage after head trauma and how these issues influence patient outcomes. The goal is to develop and validate prediction models or risk scores to better foresee coagulation-related complications following TBI. The study includes patients who arrive at the hospital within 24 hours of head trauma and have isolated traumatic brain injury, defined by specific injury scoring criteria for other body regions. Researchers will observe and analyze these patients without administering experimental treatments, focusing on natural progression and outcomes related to coagulation status. Participants will be monitored for their clinical outcomes using tools such as the Glasgow Outcome Scale at six months after injury. Data collection will likely involve thromboelastography and other clinical assessments to evaluate coagulation-related damage. The study spans from 2018 to 2027, allowing long-term observation of patient recovery and complications related to blood clotting after TBI.
CONDITIONS
Brief Title
The Utility of Thromboelastography in Traumatic Brain Injury
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients who arrive at the hospital within 24 hours after head trauma
- Patients with isolated traumatic brain injury, defined by an abbreviated injury score (AIS) of 3 or less for other body regions
- Adults aged 18 to 80 years
You will not qualify if you...
- Patients with existing prior neurological disease
- Patients with known coagulation disorders
- Patients on anticoagulants or medications affecting coagulation within 30 days before trauma
- Patients who received blood components before blood draw
- Patients who deteriorate and die before coagulation-related damage can be determined
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Within 24 hours after head trauma
Participants undergo assessments including thromboelastography to evaluate coagulation-related damages after traumatic brain injury.
1 visit (in-person)
Duration - Up to 6 months
Participants are monitored to assess outcomes such as Glasgow Outcome Scale scores over time.
Follow-up visits as scheduled during the monitoring period
Trial Site Locations
Total: 1 location
1
Shanghai Sixth People's Hospital
Shanghai, China, 200233
Actively Recruiting
Research Team
H
Hao Chen, M.D., Ph.D.
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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