Vanderbilt Memory and Aging Project studying vascular health and early Alzheimers and brain aging in adults 60 and older

What this Trial Is About

Researchers are investigating how vascular health relates to early signs of Alzheimers disease and cerebrovascular disease in aging adults. This observational study aims to understand the connections between vascular health and changes seen in brain imaging, cognitive tests, and biological markers before significant memory or thinking problems begin. The study also explores how factors like inflammation, insulin resistance, and genetics, including the APOE gene, may influence brain aging. Participants include adults aged 50 and older, both cognitively healthy and those with mild cognitive impairment but no dementia. The study follows them over time, using detailed brain MRI scans, blood tests, cerebrospinal fluid collection via lumbar puncture, and neuropsychological assessments. These procedures help monitor brain structure, blood flow, and biological markers related to Alzheimers and vascular health. Participants undergo a thorough initial screening visit lasting about four hours to assess cognitive status. Regular follow-ups include imaging, biological sample collection, and cognitive testing over several years. Researchers measure changes in brain areas, blood flow, heart function, and genetic markers to better understand how vascular health impacts brain aging. The study is sponsored by Vanderbilt University Medical Center and involves continuous monitoring to capture early disease changes.

Vanderbilt Memory and Aging Project