Actively Recruiting
Vanderbilt Memory and Aging Project
Led by Vanderbilt University Medical Center · Updated on 2025-08-06
1000
Participants Needed
1
Research Sites
745 weeks
Total Duration
On this page
Sponsors
V
Vanderbilt University Medical Center
Lead Sponsor
N
National Institute on Aging (NIA)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study will use an observational cohort to cross-sectionally and longitudinally relate vascular health to clinical, imaging, and biological markers of early Alzheimer's disease and cerebrovascular disease among aging adults. Adjusting for relevant clinical covariates, we will test the hypothesis that vascular health is associated with clinical, brain magnetic resonance imaging (MRI), neuropsychological, and cerebrospinal fluid markers of early cerebrovascular and Alzheimer's disease changes (i.e., prior to the onset of significant cognitive decline or dementia). Secondarily, we will examine medical and genetic factors that might mediate associations between vascular health and brain aging, such as inflammatory processes, insulin resistance, and genetic factors (e.g., APOE, a susceptibility risk factor for dementia). Findings will advance knowledge regarding the role that vascular health plays in brain aging.
CONDITIONS
Official Title
Vanderbilt Memory and Aging Project
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 50 years and older
- Participants include approximately 150 individuals diagnosed with mild cognitive impairment without dementia
- Remaining participants are cognitively unimpaired adults aged 50 and older
- English must be the participant's primary language
You will not qualify if you...
- No reliable study partner available
- History of major psychiatric illnesses such as schizophrenia or bipolar disorder
- History of neurological illnesses including stroke, epilepsy, multiple sclerosis, Parkinson's disease, or dementia
- History of head injury with significant loss of consciousness
- Diagnosis of congestive heart failure
- Diagnosis of atrial fibrillation or other heart arrhythmias
- Diagnosis of chronic obstructive pulmonary disease
- Current diagnosis of cancer
- History of serious alcohol or drug abuse
- Unable to undergo MRI due to implanted medical devices, ferromagnetic implants, cerebral aneurysm clips, shrapnel, or excessive metal dental work
- Pregnancy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Vanderbilt University Medical Center
Nashville, Tennessee, United States, 37232
Actively Recruiting
Research Team
M
Mallory Rockwell
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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