Actively Recruiting
The Vanguard Study: Testing a New Way to Screen for Cancer
Led by National Cancer Institute (NCI) ยท Updated on 2026-06-01
24000
Participants Needed
37
Research Sites
21 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating multi-cancer detection (MCD) tests as new tools to screen for multiple cancers at once by measuring markers in the blood. This trial aims to explore how well these tests work for cancer screening, their impact on patients and doctors in making care decisions, and how to conduct such studies in the future. Adults aged 45 to 75 without cancer are included to help assess the feasibility and performance of these MCD tests compared to standard care. Participants are randomly assigned to one of three groups: two groups undergo blood collection for different MCD tests called Shield and Avantect at enrollment and after one year, and a control group undergoes blood collection without MCD testing. Some study sites provide participants with their test results (unblinded) while others only provide abnormal results (blinded). Those with abnormal results are advised to follow up with their clinicians for further testing. After the intervention, participants are followed passively for up to 10 years. Throughout the study, participants complete questionnaires and provide blood samples at specified times. Researchers collect medical record data and monitor adherence to the protocol, timing of test result returns, diagnostic follow-ups for abnormal results, and participants' anxiety and cancer worry. The study measures feasibility outcomes such as enrollment, follow-up completion, and diagnostic resolution, as well as clinical performance of the MCD tests. Safety and long-term outcomes, including cancer incidence and mortality, are also observed.
CONDITIONS
Brief Title
The Vanguard Study: Testing a New Way to Screen for Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Ages 45-75 years old
- Agree to provide blood samples for possible MCD testing at enrollment and at 1 year following enrollment
- Agree to allow collection of information from their medical records for study-related purposes
- Understand and be able to complete informed consent and participant questionnaires in English, Spanish, or Arabic
- Note: Eligibility for Spanish and Arabic languages are at the Hub's discretion
You will not qualify if you...
- Solid malignant tumor or blood cancer diagnosis, with or without treatment, within the last 5 years
- Ongoing cancer diagnostic work-up
- Ongoing participation in another study of an investigational cancer screening test or technology
- Currently breastfeeding or pregnant, or planning to become pregnant in the next year
- Note: Persons with a history of in situ cancers or nonmelanoma skin cancer are eligible
AI-Screening
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Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person) for enrollment and initial blood collection
Duration - 1 year
Participants undergo blood collection for Multi-Cancer Detection (MCD) testing at enrollment and after one year on study. Participants with abnormal results follow up with their clinician for additional testing as needed.
2 visits (in-person) for blood collection at enrollment and at 1 year
Duration - Up to 10 years
After completion of the initial study intervention, participants are followed passively for up to 10 years to assess outcomes and health status.
No scheduled visits; passive follow-up through health records
Trial Site Locations
Total: 37 locations
1
Kaiser Permanente-Division of Research
Pleasanton, California, United States, 94588
Actively Recruiting
2
Keefe Memorial Hospital
Cheyenne Wells, Colorado, United States, 80810
Actively Recruiting
3
Kaiser Permanente-Franklin
Denver, Colorado, United States, 80205
Actively Recruiting
4
Poudre Valley Hospital
Fort Collins, Colorado, United States, 80524
Actively Recruiting
5
Cancer Care and Hematology-Fort Collins
Fort Collins, Colorado, United States, 80528
Actively Recruiting
6
UCHealth Greeley Hospital
Greeley, Colorado, United States, 80631
Actively Recruiting
7
Kaiser Permanente-Rock Creek
Lafayette, Colorado, United States, 80026
Actively Recruiting
8
Kaiser Permanente-Lone Tree
Lone Tree, Colorado, United States, 80124
Actively Recruiting
9
Medical Center of the Rockies
Loveland, Colorado, United States, 80538
Actively Recruiting
10
Kaiser Permanente Moanalua Medical Center
Honolulu, Hawaii, United States, 96819
Actively Recruiting
11
Henry Ford Cancer Institute-Downriver
Brownstown, Michigan, United States, 48183
Actively Recruiting
12
Henry Ford Health Center - Brownstown
Brownstown, Michigan, United States, 48183
Actively Recruiting
13
Henry Ford Health Center - Chesterfield
Chesterfield, Michigan, United States, 48047
Actively Recruiting
14
Henry Ford Macomb Hospital-Clinton Township
Clinton Township, Michigan, United States, 48038
Actively Recruiting
15
Henry Ford Medical Center-Fairlane
Dearborn, Michigan, United States, 48126
Actively Recruiting
16
Henry Ford Hospital
Detroit, Michigan, United States, 48202
Actively Recruiting
17
Henry Ford Medical Center - Detroit Northwest
Detroit, Michigan, United States, 48235
Actively Recruiting
18
Henry Ford Medical Center-Cottage
Grosse Pointe Farms, Michigan, United States, 48236
Actively Recruiting
19
Henry Ford Medical Center - Livonia
Livonia, Michigan, United States, 48150
Actively Recruiting
20
Henry Ford Medical Center-Columbus
Novi, Michigan, United States, 48377
Actively Recruiting
21
Henry Ford Medical Center - Plymouth
Plymouth, Michigan, United States, 48170
Actively Recruiting
22
Henry Ford Medical Center - Royal Oak
Royal Oak, Michigan, United States, 48067
Actively Recruiting
23
Henry Ford Medical Center
Sterling Heights, Michigan, United States, 48310
Actively Recruiting
24
Henry Ford Medical Center - Troy
Troy, Michigan, United States, 48083
Actively Recruiting
25
Henry Ford West Bloomfield Hospital
West Bloomfield, Michigan, United States, 48322
Actively Recruiting
26
Henry Ford Wyandotte Hospital
Wyandotte, Michigan, United States, 48192
Actively Recruiting
27
Saint Luke's Hospital of Kansas City
Kansas City, Missouri, United States, 64111
Actively Recruiting
28
Washington University School of Medicine
St Louis, Missouri, United States, 63110
Actively Recruiting
29
UNC Lineberger Comprehensive Cancer Center
Chapel Hill, North Carolina, United States, 27599
Actively Recruiting
30
University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma, United States, 73104
Actively Recruiting
31
Sentara Martha Jefferson Hospital
Charlottesville, Virginia, United States, 22911
Actively Recruiting
32
Inova Schar Cancer Institute
Fairfax, Virginia, United States, 22031
Actively Recruiting
33
Inova Fair Oaks Hospital
Fairfax, Virginia, United States, 22033
Actively Recruiting
34
Sentara Norfolk General Hospital
Norfolk, Virginia, United States, 23507
Actively Recruiting
35
VCU Massey Cancer Center at Stony Point
Richmond, Virginia, United States, 23235
Actively Recruiting
36
VCU Massey Comprehensive Cancer Center
Richmond, Virginia, United States, 23298
Actively Recruiting
37
VCU Community Memorial Health Center
South Hill, Virginia, United States, 23970
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SCREENING
Number of Arms
3
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