Actively Recruiting
99mTc-PSMA-I&S Biodistribution in Patients With Prostate Cancer
Led by Jonsson Comprehensive Cancer Center · Updated on 2026-03-13
30
Participants Needed
1
Research Sites
318 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This exploratory study conducted under the RDRC program studies the biodistribution of 99mTc-PSMA-I\&S in patients with prostate cancer who undergo pelvic lymph node dissection. Prostate specific membrane antigen (PSMA)-targeted radio-guided surgery uses the preoperative intravenous administration of a PSMA-ligand called PSMA-imaging and surgery (I\&S) labeled with the gamma-emitter radioisotope Technetium-99m (99mTc). Giving 99mTc-PSMA-I\&S may detect PSMA-expressing lymph nodes during surgery using a gamma probe and may help guide doctors to detect prostate cancer that has spread to the lymph nodes.
CONDITIONS
Official Title
99mTc-PSMA-I&S Biodistribution in Patients With Prostate Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Men with prostate cancer (primary or recurrent disease)
- Men who have had a 68Ga-PSMA-11 PET/CT scan for staging or restaging
- Men with lymph node-positive disease shown on 68Ga-PSMA-11 PET/CT
- Men scheduled for pelvic lymph node dissection surgery
- Men able to give oral and written informed consent
- Men able to follow study procedures
You will not qualify if you...
- Patients who started any prostate cancer treatment between enrollment and surgery
- Patients with lymph nodes in locations that are technically inaccessible
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
UCLA / Jonsson Comprehensive Cancer Center
Los Angeles, California, United States, 90095
Actively Recruiting
Research Team
D
Deepu Varughese
CONTACT
A
Ankush Sachdeva
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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