Increasing Follow-Up Colonoscopy After Abnormal Stool Tests for Colorectal Cancer Using Patient Support and Education

What this Trial Is About

Researchers are evaluating whether a multilevel intervention can increase follow-up colonoscopy completion after abnormal fecal immunochemical test FIT results in colorectal cancer CRC screening. This trial focuses on patients aged 45 to 75 who have abnormal non-invasive CRC screening results and aims to address patient and health system barriers to completing recommended colonoscopy tests. The study is sponsored by Fred Hutchinson Cancer Center and involves a randomized design comparing usual care with an enhanced intervention. Participants are randomly assigned to one of two groups. Group I receives usual care from a CRC screening navigator who provides monthly phone calls and help with colonoscopy scheduling. Group II receives the same usual care plus additional support including access to an educational video addressing fears about colonoscopy and transportation assistance home after the procedure through a rideshare program arranged by the discharge nurse. After the intervention, participants are followed for 18 months to assess outcomes. During the study, participants undergo evaluations to track colonoscopy completion rates and timing, referrals, and scheduling up to 18 months after randomization. Researchers also assess intervention reach, acceptability, fidelity, and costs weekly for up to 8 months. Data collection includes surveys, interviews, and electronic health record reviews. Participants can expect regular monitoring and support throughout the study period, which continues until January 2030.

A Multilevel Intervention to Increase Colorectal Cancer Screening Tests in Patients With Abnormal Fecal Immunochemical Test Results, PROACT Trial