Actively Recruiting
Ventricular Arrhythmias in Patients Undergoing Mitral Valve Surgery
Led by Karolinska Institutet · Updated on 2025-09-11
90
Participants Needed
1
Research Sites
105 weeks
Total Duration
On this page
Sponsors
K
Karolinska Institutet
Lead Sponsor
K
Karolinska University Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
Study objectives: * To assess the impact of mitral valve surgery for mitral regurgitation on ventricular arrhythmic burden and surrogate markers of fibrosis in patients with arrhytmogenic mitral valve prolapse (MVP) from baseline to 6 months after surgery * To characterize the molecular landscape of arrhytmogenic MVP Study design: -Prospective explorative observational study Study population: -90 patients with arrhytmogenic MVP and without arrhytmogenic MVP (controls) eligible for mitral valve surgery for mitral regurgitation will be enrolled. All patients will be evaluated with cardiac magnetic resonance (CMR) imaging and continuous seven day arrhythmic monitoring before and at 6 months after mitral valve surgery
CONDITIONS
Official Title
Ventricular Arrhythmias in Patients Undergoing Mitral Valve Surgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 and over
- Patients with and without (controls) arrhythmogenic MVP in need of mitral valve surgery for primary mitral regurgitation according to current standard of care
You will not qualify if you...
- Secondary mitral regurgitation
- Primary mitral regurgitation not due to degenerative disease (including rheumatic disease)
- Co-existing moderate or severe aortic valve disease
- Congenital heart disease
- Inherited or acquired cardiomyopathy
- Non-incidental or symptomatic coronary artery disease
- Uncontrolled atrial fibrillation (resting heart rate > 100/min)
- Pregnancy
- Unable to undergo CMR
AI-Screening
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Trial Site Locations
Total: 1 location
1
Karolinska Univeristy Hospital
Stockholm, Stockholm County, Sweden, 171 76
Actively Recruiting
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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