Study of Heart Rhythm and Fibrosis Changes After Mitral Valve Surgery in Patients with Arrhythmic and Non-Arrhythmic Mitral Valve Prolapse

What this Trial Is About

This research aims to understand how mitral valve surgery affects ventricular arrhythmias and fibrosis markers in patients with arrhythmogenic mitral valve prolapse MVP who have mitral regurgitation. The study will also explore the molecular characteristics of arrhythmogenic MVP. It involves both patients with arrhythmogenic MVP and control patients without arrhythmogenic MVP, all scheduled for mitral valve surgery. Participants will undergo mitral valve surgery, which includes either repair or replacement due to mitral regurgitation, following the current standard of care. The study will use cardiac magnetic resonance imaging CMR and continuous seven-day arrhythmic monitoring before surgery and again six months afterward to assess changes. During surgery, tissue samples from the mitral valve and endocardial biopsies will be collected for detailed molecular analysis. Participants will be closely monitored through imaging and arrhythmia tracking before and six months after surgery. Researchers will measure ventricular arrhythmias and extracellular volume as primary outcomes to evaluate changes after surgery. The study involves 90 patients and includes molecular phenotyping to better understand the disease mechanisms. The total study time for each participant is at least six months following their surgery.

Ventricular Arrhythmias in Patients Undergoing Mitral Valve Surgery