Detecting Circulating Blood Clots Using Photoacoustic Flow Cytometry in Adults with Thromboembolism

What this Trial Is About

Researchers are evaluating the use of a new device called Photoacoustic Flow Cytometry PAFC to detect circulating blood clots in patients with thromboembolic disease or those at high risk for such conditions. Current standard methods have limited sensitivity, especially when clot numbers in the blood are low, so this study aims to test whether PAFC can improve detection and potentially reduce complications from undetected clots. Participants will undergo the PAFC procedure, which is a novel imaging technique designed to identify clots in the bloodstream. The study does not involve comparison with other treatments but focuses on assessing the feasibility and safety of this device. The research includes monitoring for any skin sensitivity or changes related to the PAFC method over a 30-day period. During the study, patients will be evaluated through PAFC scans and blood tests measuring D-dimer levels, which are markers of clot presence. Researchers will compare clot detection results between PAFC and D-dimer tests and monitor any skin reactions. The trial involves a 30-day follow-up to assess safety and the relationship between PAFC signals and actual circulating clots. Participants will be closely observed but will continue to receive their usual care.

In Vivo Detection of Circulating Clots in Patients With Thromboembolism