Death by clot: acute coronary syndromes, ischemic stroke, pulmonary embolism, and disseminated intravascular coagulation.
Diane K Dressler
https://pubmed.ncbi.nlm.nih.gov/19411875Actively Recruiting
Phase Not Applicable
Age: 18Years +
All Genders
ID05301348
In Vivo Detection of Circulating Clots in Patients With Thromboembolism
Led by University of Arkansas · Updated on 2026-02-19
30
Participants Needed
1
Research Sites
4 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating the use of a new device called Photoacoustic Flow Cytometry (PAFC) to detect circulating blood clots in patients with thromboembolic disease or those at high risk for such conditions. Current standard methods have limited sensitivity, especially when clot numbers in the blood are low, so this study aims to test whether PAFC can improve detection and potentially reduce complications from undetected clots. Participants will undergo the PAFC procedure, which is a novel imaging technique designed to identify clots in the bloodstream. The study does not involve comparison with other treatments but focuses on assessing the feasibility and safety of this device. The research includes monitoring for any skin sensitivity or changes related to the PAFC method over a 30-day period. During the study, patients will be evaluated through PAFC scans and blood tests measuring D-dimer levels, which are markers of clot presence. Researchers will compare clot detection results between PAFC and D-dimer tests and monitor any skin reactions. The trial involves a 30-day follow-up to assess safety and the relationship between PAFC signals and actual circulating clots. Participants will be closely observed but will continue to receive their usual care.
CONDITIONS
Brief Title
In Vivo Detection of Circulating Clots in Patients With Thromboembolism
Who Can Participate
Age: 18Years +
All Genders
Eligibility Criteria
You may qualify if you...
- Men and women, 18 years old and older
- Evidence of current venous or arterial thromboembolic disease diagnosed by standard of care clinical, radiographic, or laboratory testing or acute ischemic stroke
- Informed consent provided by the subject
You will not qualify if you...
- Pulmonary embolus requiring mechanical ventilation or other ventilator support beyond oxygen by nasal cannula or mask at FiO2 ≤ 0.40
- Acute coronary syndrome including unstable angina
- Significant cardiac arrhythmia (except controlled atrial fibrillation)
- Intracardiac thrombus
- Embolus or thrombus requiring vascular surgery or interventional radiology for acute embolectomy or thrombectomy
- Sickle cell disease with vaso-occlusive crisis
- Sepsis or life-threatening infection
- Traumatic injury requiring hospitalization within 30 days prior to enrollment
- Pregnancy or breastfeeding
- Severe mental illness
- Other conditions deemed by investigators to increase subject risk
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Implementation
Duration - Up to 30 days
Participants undergo the Photoacoustic Flow Cytometry (PAFC) procedure to detect circulating blood clots.
1 procedure visit
Long-term Monitoring
Duration - Up to 30 days
Participants are monitored for safety and outcomes related to the PAFC procedure including skin sensitivity and skin property changes.
Follow-up assessments during the 30-day period
Trial Site Locations
Total: 1 location
1
Univerisity of Arkansas for Medical Sciences
Little Rock, Arkansas, United States, 72205
Actively Recruiting
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Research Team
S
Sanjeeva Onteddu, MD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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Published Research Related To This Trial
Synergy of photoacoustic and fluorescence flow cytometry of circulating cells with negative and positive contrasts.
Dmitry A Nedosekin, Mustafa Sarimollaoglu, Ekaterina I Galanzha...
https://pubmed.ncbi.nlm.nih.gov/22903924Noninvasive label-free detection of circulating white and red blood clots in deep vessels with a focused photoacoustic probe.
Mazen A Juratli, Yulian A Menyaev, Mustafa Sarimollaoglu...
https://pubmed.ncbi.nlm.nih.gov/30460154Epidemiology and risk factors for venous thrombosis.
Mary Cushman
https://pubmed.ncbi.nlm.nih.gov/17433897Venous thromboembolism: disease burden, outcomes and risk factors.
J A Heit
https://pubmed.ncbi.nlm.nih.gov/16102026A population-based perspective of the hospital incidence and case-fatality rates of deep vein thrombosis and pulmonary embolism. The Worcester DVT Study.
F A Anderson, H B Wheeler, R J Goldberg...
https://pubmed.ncbi.nlm.nih.gov/2025141Real-Time Label-Free Embolus Detection Using In Vivo Photoacoustic Flow Cytometry.
Mazen A Juratli, Yulian A Menyaev, Mustafa Sarimollaoglu...
https://pubmed.ncbi.nlm.nih.gov/27227413In vivo flow cytometry of circulating clots using negative photothermal and photoacoustic contrasts.
Ekaterina I Galanzha, Mustafa Sarimollaoglu, Dmitry A Nedosekin...
https://pubmed.ncbi.nlm.nih.gov/21976458Photoacoustic flow cytometry.
Ekaterina I Galanzha, Vladimir P Zharov
https://pubmed.ncbi.nlm.nih.gov/22749928