Actively Recruiting
Web-based Application to Test for Long-term Cognitive Deficits in BioCog Patients
Led by Charite University, Berlin, Germany · Updated on 2025-11-21
434
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
C
Charite University, Berlin, Germany
Lead Sponsor
U
University Hospital, Bonn
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are conducting a long-term follow-up study to explore changes in cognitive abilities and daily functioning among former BioCog study participants from Berlin. This observational research examines cognitive performance 7 to 10 years after the original study inclusion, using classifications from ICD-10 and DSM-5, as well as computer-based cognitive tests and questionnaires related to memory, depression, and daily activities. The study is a collaboration between several German universities and medical centers. The study involves contacting former BioCog patients and non-surgical comparison subjects who previously completed baseline cognitive tests and provided plasma samples. Follow-up assessments include a medical telephone or video visit, and participants complete cognitive tests and usability questionnaires online from home. The research team uses specialized algorithms to evaluate mild and major neurocognitive disorders. Participants will be assessed through various online cognitive tests and questionnaires covering memory, depression, daily functioning, and quality of life. Researchers will monitor changes in cognitive performance and collect data on acceptance, usability, new diagnoses, medication use, comorbidities, falls, nutrition, body mass index, and mortality. The total follow-up period is 7 to 10 years after the initial BioCog study enrollment. Data analysis will help understand long-term cognitive effects in this population.
CONDITIONS
Brief Title
Web-based Application to Test for Long-term Cognitive Deficits in BioCog Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients of Berliner BioCog cohort with baseline cognitive testing (CANTAB Research Suite) and available plasma samples who can be contacted
- Written informed consent for participation in the BioCog-Web study
- Data and reserve samples from patients in the Berlin BioCog cohort who cannot be contacted
- BioCog subjects from the non-operated comparison cohort in Berlin with baseline cognitive testing who are contactable
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person or remote)
Duration - 7 to 10 years
Participants undergo long-term follow-up to assess changes in cognitive performance, self-care, functionality, and quality of life approximately 7 to 10 years after their baseline cognitive testing in the BioCog main study.
1 web-based cognitive testing session and questionnaire assessments
Trial Site Locations
Total: 1 location
1
Department of Anesthesiology and Intensive Care Medicine (CCM/CVK), Charité - University Medicine Berlin
Berlin, Germany, 13355
Actively Recruiting
Research Team
C
Claudia Spies, MD, Prof.
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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