Effect of 6 Weeks of Blood Flow Restriction Training on Immune Cell Function and Energy Use in Adults with Type 2 Diabetes

What This Trial Is About

This research aims to understand how six weeks of blood flow restriction BFR training affects immune cell function and energy use in adults living with type 2 diabetes. The study compares two groups one walking on a treadmill regularly and another walking with BFR. Participants are adults aged 19 to 64 with type 2 diabetes and moderate physical activity levels. Participants will be randomly assigned to either the treadmill walking group or the treadmill walking with BFR group. Both groups exercise three times a week for six weeks, starting with 21 minutes per session in week one and increasing to 32 minutes for the remaining weeks. The treadmill is set to keep heart rate within 40-50% of reserve. In the BFR group, cuffs inflate based on each persons limb occlusion pressure, starting at 60% and gradually rising to 80% over six weeks, with safety breaks every 10 minutes. Participants will be assessed before starting and after completing the six-week program. Researchers will measure changes in T-cell oxygen consumption and various immune cell markers using blood tests and flow cytometry. These include changes in CD4, CD8, regulatory T cells, and inflammatory markers. The study tracks immune responses and energy use in cells to understand how BFR exercise might influence health in people with type 2 diabetes.

6-Weeks of Blood Flow Restriction Training on Immune Cell Function and Bioenergetics