Actively Recruiting
Evaluation of 3D DL oZTEo in the Detection of Osseous Changes in Patients With Inflammatory Arthritis
Led by Mayo Clinic · Updated on 2025-12-17
25
Participants Needed
1
Research Sites
26 weeks
Total Duration
On this page
Sponsors
M
Mayo Clinic
Lead Sponsor
G
GE Healthcare
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are evaluating a new MRI pulse sequence called 3D DL oZTEo to detect bone erosions in the hands of patients with inflammatory arthritis. The study aims to validate this technique against current standard methods like radiography and conventional MRI, as these structural changes are important for diagnosis and treatment decisions in rheumatic conditions. This is an interventional study conducted at Mayo Clinic. Participants will have the FDA-approved oZTEo MRI pulse sequence added to their routine hand MRI scan. The oZTEo images will be anonymized and processed using a deep learning algorithm developed by GE Healthcare. This additional sequence is assessed alongside the standard MRI to compare its ability to detect bone erosions. During the study, researchers will analyze MRI scans with and without the 3D DL oZTEo sequence to determine the presence and number of bone erosions in the hand. Participants must have recent hand radiographs confirming erosions and are scheduled for hand MRI as part of their clinical care. The study measures outcomes on the day of imaging and monitors the accuracy of erosion detection.
CONDITIONS
Brief Title
3D DL Ozteo in the Detection of Osseous Changes in Patients With Inflammatory Arthritis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult patients 18 years of age
- Hand radiographs performed within the past 3-6 months with imaging results available for analysis
- Hand radiographs confirm the presence of bony erosions
- Scheduled for a hand MRI as part of their routine clinical care at Mayo Clinic Rochester
You will not qualify if you...
- Less than 18 years of age
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 1 day
Participants undergo a standard of care hand MRI examination with the addition of the FDA approved oZTEo MRI pulse sequence to detect osseous erosions of the hand.
1 MRI visit (in-person)
Duration - Up to 6 months
Participants are observed following the MRI evaluation to assess the presence and number of bony erosions using the 3D DL oZTEo sequence.
No additional visits required
Trial Site Locations
Total: 1 location
1
Mayo Clinic in Rochester
Rochester, Minnesota, United States, 55905
Actively Recruiting
Research Team
N
Naveen S Murthy, MD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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