Study of 7T Brain MRI to Detect Small Brain Metastases in Adults With Small-cell Lung Cancer Who Decline Preventive Brain Radiation

What this Trial Is About

Researchers are studying patients diagnosed with small-cell lung cancer SCLC who have declined prophylactic cranial irradiation PCI. The study compares the use of a 7-tesla 7t brain MRI scan to standard care 1.5t or 3t MRI scans to determine if the 7t MRI can detect brain metastases earlier than current methods. Patients must have had a recent standard MRI that showed no brain metastases to participate. Participants will first undergo a 7t MRI brain scan, followed by up to 12 months of standard care MRI scans either 1.5t or 3t. The study will monitor patients regularly through these scans to observe if and when brain metastases develop. Once brain metastases are confirmed by standard scans, the results will be compared to the earlier 7t MRI images to evaluate the potential for earlier detection. Throughout the study, participants will be followed for up to one year or until brain metastases are detected. The primary outcome is the detection of brain metastases using the 7t MRI at 3, 6, 9, and 12 months after the initial 7t scan. Patients will continue their regular clinical care and surveillance with brain MRI scans. The study involves no treatment changes but focuses on imaging assessment and monitoring.

7T Brain MRI Scan for Micro-brain Metastasis (microBM) Detection for Patients With Small-cell Lung Cancer (SCLC), Who Decline Prophylactic Cranial Irradiation (PCI)