Actively Recruiting
Led by Chang Gung Memorial Hospital · Updated on 2023-05-01
100
Participants Needed
1
Research Sites
N/A
Total Duration
Researchers are studying the use of hippocampal-sparing whole brain radiotherapy (HS-WBRT) in patients with brain metastases or those receiving prophylactic cranial irradiation mainly for small cell lung cancer. Whole brain radiotherapy (WBRT) is known to treat both visible and microscopic brain disease but can cause neurocognitive function (NCF) decline, especially affecting memory. This study aims to see if sparing the hippocampus during WBRT can preserve cognitive function better than traditional WBRT methods. Participants will receive HS-WBRT using volumetric modulated arc therapy (VMAT) with a Linac-based RapidArc device. Treatment involves a CT scan with a thermoplastic mask for head immobilization, followed by delivering 30 Gy in 12 fractions to the whole-brain planning target volume. This approach is used either after surgery to remove tumors or to treat limited brain metastases. The focus is on conformally avoiding the hippocampus to reduce radiation damage in this critical memory area. During the study, researchers will measure changes in verbal and non-verbal memory using the WMS III test at baseline and 4 months after starting HS-WBRT. Participants will also be monitored for overall survival and brain disease progression for up to 18 months. The study includes assessments such as brain MRI or CT scans and performance evaluations to track neurocognitive changes and treatment effects over time.
CONDITIONS
A Prospective Study of the Impact of Hippocampal Avoidance During Whole Brain Radiotherapy on Neurocognitive Function Decline
You may qualify if you...
You will not qualify if you...
Complete this quick 3-step screening to check your eligibility
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Approximately 2.5 weeks
Participants receive hippocampal-sparing whole brain radiotherapy using volumetric modulated arc therapy over multiple sessions.
12 treatment sessions
Duration - Up to 18 months
Participants are monitored for neurocognitive function and disease progression after treatment.
Visits at baseline, 4 months, and periodic assessments up to 18 months
Total: 1 location
1
Chang Gung Memorial Hospital
Taoyuan, Taiwan, 333
Actively Recruiting
C
Chi-Cheng Chuang, M.D.
S
Shinn-Yn Lin, M.D.
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
Have more questions? Get in touch with our team for quick support
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here
Shinn-Yn Lin, Din-Li Tsan, Chi-Cheng Chuang...
https://pubmed.ncbi.nlm.nih.gov/35096584Ping-Fang Tsai, Chi-Cheng Yang, Chi-Cheng Chuang...
https://pubmed.ncbi.nlm.nih.gov/26654128