Status:
COMPLETED
Multicenter Study of Hydroxyurea in Patients With Sickle Cell Anemia (MSH)
Lead Sponsor:
National Heart, Lung, and Blood Institute (NHLBI)
Conditions:
Anemia, Sickle Cell
Hematologic Diseases
Eligibility:
All Genders
18-50 years
Phase:
PHASE3
Brief Summary
To assess the efficacy and safety of orally administered hydroxyurea in the treatment of painful crises in patients with sickle cell anemia.
Detailed Description
BACKGROUND: In spite of the fact that advances have been made in the management or prevention of some of the complications of sickle cell disease, the management of the most common complication--the ...
Eligibility Criteria
Men and women, ages 18 to 50, who had at least three emergency room visits or hospitalizations for sickle cell anemia during the year prior to recruitment. Patients with greater than 20 crises per year were included. A total of 295 patients had Hb ss and four had Hb SB thalassemia.
Key Trial Info
Start Date :
January 1 1992
Trial Type :
INTERVENTIONAL
End Date :
June 1 1994
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT00000586
Start Date
January 1 1992
End Date
June 1 1994
Last Update
April 14 2016
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