Pilot Study of Personalized Accelerated Transcranial Magnetic Stimulation Using Brain Scans for Adults With PTSD

What this Trial Is About

Researchers are evaluating a new brain stimulation treatment called accelerated transcranial magnetic stimulation TMS for adults aged 18 to 65 with post-traumatic stress disorder PTSD. PTSD causes symptoms like flashbacks, avoidance, mood changes, and heightened alertness after trauma. This pilot study focuses on using brain scans to guide personalized TMS targeting the brain areas involved in fear and control to improve symptoms. The study aims to assess if this fast-paced treatment is practical, safe, and shows early signs of reducing PTSD symptoms. Participants first undergo a brain scan fMRI to map connections between their right amygdala fear center and right dorsolateral prefrontal cortex control area. Using this map, they receive accelerated continuous theta burst stimulation cTBS to the identified brain target. Treatment lasts 5 consecutive days with 10 short sessions each day, totaling 90,000 magnetic pulses. The procedure uses a neuronavigation system for precise coil placement and is monitored continuously for safety. During the study, participants have a screening and baseline phase, followed by the 5-day treatment and then a 3-month follow-up period. Researchers assess PTSD symptoms using questionnaires and interviews at baseline, after treatment, and at 1 and 3 months. Repeat brain scans evaluate changes in brain connectivity. Safety is closely monitored throughout, including side effects like headaches. Total participation lasts about 3.5 months.

Accelerated Transcranial Magnetic Stimulation for Post-Traumatic Stress Disorder