Study of Adults and Children with Stills Disease to Understand Its Causes and Improve Care

What this Trial Is About

Adult Onset Still Disease AOSD and Systemic onset Juvenile Idiopathic Arthritis SoJIA are rare inflammatory diseases considered two forms of the same syndrome. They involve symptoms like high fever, joint pain or arthritis, skin rash, and a high neutrophil count. These diseases affect both children and adults differently, with variable disease courses including flare-ups or chronic joint problems. The underlying causes remain unknown, though inflammatory pathways and immune system abnormalities are believed to play a role. The study aims to improve understanding of these diseases, compare pediatric and adult forms, identify early markers, and support new therapy evaluation through standardized patient follow-up. This observational study involves adult and pediatric patients diagnosed with Stills disease using established criteria. Participants will be followed over time with regular collection of clinical and biological data, including signs of disease activity, inflammation markers, and quality of life assessments. The study does not involve treatment interventions but gathers detailed information to inform better disease management and research. Participants will be monitored for general and clinical disease signs, biological test results, and the impact on daily life at yearly intervals for up to 5 years. Additional assessments include quality of life scores, disease activity indices, prospective biomarkers, and family history of autoinflammatory diseases. This long-term follow-up aims to track disease progression and outcomes to enhance knowledge and care strategies for Stills disease.

Acostill ( RaDiCo Cohort) (RaDiCo Acostill)