Actively Recruiting
AutoInflammatory Disease Alliance Registry (AIDA)
Led by University of Siena · Updated on 2025-07-10
3500
Participants Needed
112
Research Sites
521 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Autoinflammatory diseases (AID) are clinical entities characterized by recurrent inflammatory attacks in absence of infection, neoplasm or deregulation of the adaptive immune system. Among them, hereditary periodic syndromes, also known as monogenic AID, represent the prototype of this disease group, caused by mutations in genes involved in the regulation of innate immunity, inflammation and cell death. Based on recent experimental acquisitions in the field of monogenic AID, several immunologic disorders have been reclassified as polygenic/multifactorial AID, sharing pathogenetic and clinical features with hereditary periodic fevers. This has paved the way to new treatment targets for patients suffering from rare diseases of unknown origin, including Behçet's disease, Still disease, Schnitzler's disease, PFAPA (periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis) syndrome, chronic recurrent multifocal osteomyelitis (CRMO), non-infectious uveitis and scleritis. Gathering information on such rare conditions is made difficult by the small number of patients, along with the difficulty of obtaining an accurate diagnosis in non-specialized clinical settings. In this context, the AIDA project promotes international collaboration among clinical centres to develop a permanent registry aimed at collecting demographic, genetic, clinical and therapeutic data of patients affected by monogenic and polygenic AID, in order to expand the current knowledge of these rare conditions.
CONDITIONS
Official Title
AutoInflammatory Disease Alliance Registry (AIDA)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosed with a monogenic autoinflammatory disease confirmed by clinical phenotype and genotype
- Diagnosed with familial Mediterranean fever, Behcet's disease, Still disease, PFAPA syndrome, Schnitzler's disease, or chronic recurrent multifocal osteomyelitis using accepted clinical criteria
- Diagnosed with undifferentiated systemic autoinflammatory disease
- Diagnosed with non-infectious uveitis according to standard nomenclature criteria
- Diagnosed with anterior or posterior non-infectious scleritis
- Diagnosed with spondyloarthritis according to ASAS and/or New York criteria
- Diagnosed with Castleman disease
You will not qualify if you...
- Patient or legal representative has not provided informed consent or assent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 112 locations
1
University Algiers 1
Algiers, Algeria
Actively Recruiting
2
Université M'Hamed Bougara de Boumerdas
Boumerdas, Algeria
Actively Recruiting
3
Flinders University
Adelaide, Australia
Actively Recruiting
4
University of Adelaide
Adelaide, Australia
Actively Recruiting
5
Antwerp University Hospital
Antwerp, Belgium
Actively Recruiting
6
Hospital das Clinicas da Faculdade de Medicina HCFMUSP
São Paulo, Brazil
Actively Recruiting
7
Peking University People's Hospital
Beijing, China
Actively Recruiting
8
The First Affiliated Hospital of Chongqing Medical University
Chongqing, China
Actively Recruiting
9
Universidad del Rosario - Escuela de Medicina Y Ciencias de La Salud
Bogotá, Colombia
Actively Recruiting
10
Mansoura University, Faculty of Medicine
Al Mansurah, Egypt
Actively Recruiting
11
Al-Azhar University
Cairo, Egypt
Actively Recruiting
12
Cairo University
Cairo, Egypt
Actively Recruiting
13
Universitätsklinikum Schleswig-Holstein
Lübeck, Germany
Actively Recruiting
14
Evangelismos General Hospital
Athens, Greece
Actively Recruiting
15
National and Kapodistrian University of Athens
Athens, Greece
Actively Recruiting
16
National and Kapodistrian University of Athens
Athens, Greece
Actively Recruiting
17
Prabha Eye Clinic & Research Centre
Bangalore, India
Actively Recruiting
18
Postgraduate Institute of Medical Education and Research
Chandigarh, India
Actively Recruiting
19
Shariati Hospital - Tehran University of Medical Sciences
Tehran, Iran
Actively Recruiting
20
Azienda Ospedaliero-Universitaria Senese
Siena, Tuscany, Italy, 53100
Actively Recruiting
21
AOUC Policlinico di Bari
Bari, Italy
Actively Recruiting
22
University of Bari Medical School
Bari, Italy
Actively Recruiting
23
University-Hospital of Bari - UOC Medicina Interna
Bari, Italy
Actively Recruiting
24
University-Hospital of Bari - UOC Pediatria
Bari, Italy
Actively Recruiting
25
University-Hospital of Bari - UOC Reumatologia
Bari, Italy
Actively Recruiting
26
Central Hospital of Bolzano
Bolzano, Italy
Actively Recruiting
27
ASST degli Spedali Civili - P.O. Ospedale dei Bambini
Brescia, Italy
Actively Recruiting
28
ASST degli Spedali Civili
Brescia, Italy
Actively Recruiting
29
Azienda Ospedaliera Universitaria di Cagliari
Cagliari, Italy
Actively Recruiting
30
AOU Policlinico Vittorio Emanuele - Dip. Materno-Infantile
Catania, Italy
Actively Recruiting
31
ARNAS Garibaldi - Catania
Catania, Italy
Actively Recruiting
32
Azienda Ospedaliera di Catanzaro Pugliese Ciaccio
Catanzaro, Italy
Actively Recruiting
33
Ospedale SS Annunziata
Chieti, Italy
Actively Recruiting
34
Ospedale San Paolo
Civitavecchia, Italy
Actively Recruiting
35
Arcispedale Sant'Anna
Ferrara, Italy
Actively Recruiting
36
Azienda Ospedaliera Universitaria Careggi - SOD Medicina Interna Interdisciplinare
Florence, Italy
Actively Recruiting
37
Azienda Ospedaliero-Universitaria Careggi - SOD Immunologia e Terapie Cellulari
Florence, Italy
Actively Recruiting
38
Azienda Ospedaliero-Universitaria Meyer
Florence, Italy
Actively Recruiting
39
Azienza Ospedaliero-Universitaria Careggi - SOD Reumatologia
Florence, Italy
Actively Recruiting
40
Ospedale San Giovanni di Dio
Florence, Italy
Actively Recruiting
41
Sapienza University - Polo Pontino
Latina, Italy
Actively Recruiting
42
Ospedale Vito Fazzi
Lecce, Italy
Actively Recruiting
43
ASL1 Avezzano, Sulmona, L'Aquila
L’Aquila, Italy
Actively Recruiting
44
Università degli Studi di L'Aquila - UOC Medicina Interna e Nefrologia
L’Aquila, Italy
Actively Recruiting
45
AOU Policlinico G. Martino
Messina, Italy
Actively Recruiting
46
ASST Gaetano Pini/ CTO
Milan, Italy
Actively Recruiting
47
Policlinico di Milano
Milan, Italy
Actively Recruiting
48
ASST Fatebenefratelli Sacco - UO Medicina Generale
Milan, Italy
Actively Recruiting
49
ASST Fatebenefratelli Sacco - UOC Reumatologia
Milan, Italy
Actively Recruiting
50
ASST Gaetano Pini/CTO
Milan, Italy
Actively Recruiting
51
IRCCS Ospedale San Raffaele
Milan, Italy
Actively Recruiting
52
Ospedale Fatebenefratelli e Oftalmico
Milan, Italy
Actively Recruiting
53
Ospedale Fatebenefratelli e Oftalmico
Milan, Italy
Actively Recruiting
54
AORN Cardarelli
Naples, Italy
Actively Recruiting
55
AOU Federico II
Naples, Italy
Actively Recruiting
56
AOU Federico II
Naples, Italy
Actively Recruiting
57
AOU Luigi Vanvitelli - UO Reumatologia
Naples, Italy
Actively Recruiting
58
AOU Luigi Vanvitelli - UOC Pediatria 2
Naples, Italy
Actively Recruiting
59
Azienda Ospedaliera Universitaria di Padova
Padova, Italy
Actively Recruiting
60
ARNAS Civico Di Cristina Benfratelli
Palermo, Italy
Actively Recruiting
61
ARNAS Ospedale Civico di Cristina Benfratelli
Palermo, Italy
Actively Recruiting
62
Azienda Ospedaliera Ospedali Riuniti Villa Sofia-Cervello
Palermo, Italy
Actively Recruiting
63
Università degli Studi di Palermo
Palermo, Italy
Actively Recruiting
64
Fondazione IRRCS San Matteo - SC Reumatologia
Pavia, Italy
Actively Recruiting
65
Azienda Ospedaliera di Perugia
Perugia, Italy
Actively Recruiting
66
Azienda Ospedaliero Universitaria Pisana
Pisa, Italy
Actively Recruiting
67
University of Pisa
Pisa, Italy
Actively Recruiting
68
AOU Policlinico Umberto I
Roma, Italy
Actively Recruiting
69
Azienda Ospedaliera San Camillo Forlanini
Roma, Italy
Actively Recruiting
70
IRCCS Fondazione PU Agostino Gemelli - UOC Medicina Interna Columbus
Roma, Italy
Actively Recruiting
71
IRCCS Fondazione PU Agostino Gemelli - UOC Pediatria
Roma, Italy
Actively Recruiting
72
Ospedale Pediatrico Bambino Gesù
Roma, Italy
Actively Recruiting
73
Ospedale Universitario Campus Bio-Medico
Roma, Italy
Actively Recruiting
74
Sapienza University - Polo Pontino
Roma, Italy
Actively Recruiting
75
Università di Roma Tor Vergata
Roma, Italy
Actively Recruiting
76
Azienda Ospedaliera Universitaria di Salerno
Salerno, Italy
Actively Recruiting
77
ATS Sardegna
Tempio Pausania, Italy
Actively Recruiting
78
AO Ordine Mauriziano
Torino, Italy
Actively Recruiting
79
A.S.L. Vercelli - Ospedale S. Andrea
Vercelli, Italy
Actively Recruiting
80
Azienda Ospedaliera Universitaria Integrata
Verona, Italy
Actively Recruiting
81
Tripoli Children Hospital
Tripoli, Libya
Actively Recruiting
82
Tripoli Children Hospital
Tripoli, Libya
Actively Recruiting
83
University Hospital of Martinique
Fort-de-France, Martinique
Actively Recruiting
84
Asociacion para Evitar la Ceguera en México
Mexico City, Mexico
Actively Recruiting
85
Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
Mexico City, Mexico
Actively Recruiting
86
Medical University of Lodz
Lodz, Poland
Actively Recruiting
87
Central Clinical Hospital of the Ministry of National Defense - Military Institute of Medicine
Warsaw, Poland
Actively Recruiting
88
Sf. Maria Hospital - University of Medicine and Pharmacy "Carol Davila"
Bucharest, Romania
Actively Recruiting
89
Jazan University
Jizan, Saudi Arabia
Actively Recruiting
90
King Faisal Specialist Hospital and Research Center
Riyadh, Saudi Arabia
Actively Recruiting
91
King Saud University
Riyadh, Saudi Arabia
Actively Recruiting
92
Hospital Universitario Cruces - Instituto de investigación sanitaria Biocruces
Barakaldo, Spain
Actively Recruiting
93
Hospital Universitario Cruces
Barakaldo, Spain
Actively Recruiting
94
Hospital Clinic of Barcelona
Barcelona, Spain
Actively Recruiting
95
Hospital Fundación Jiménez Díaz
Madrid, Spain
Actively Recruiting
96
Hospital Ramón y Cajal
Madrid, Spain
Actively Recruiting
97
Hospital Universitario Fundación Jiménez Díaz/Hospital Universitario Rey Juan Carlos
Madrid, Spain
Actively Recruiting
98
Hospital Universitario Marqués de Valdecilla
Santander, Spain
Actively Recruiting
99
Hospital Universitari Doctor Peset
Valencia, Spain
Actively Recruiting
100
Farhat Hached Hospital
Sousse, Tunisia
Actively Recruiting
101
Çukurova University
Adana, Turkey (Türkiye)
Actively Recruiting
102
Ankara Yıldırım Beyazıt University
Ankara, Turkey (Türkiye)
Actively Recruiting
103
Gazi University
Ankara, Turkey (Türkiye)
Actively Recruiting
104
Hacettepe University Faculty of Medicine
Ankara, Turkey (Türkiye)
Actively Recruiting
105
Başakşehir Çam and Sakura City Hospital
Istanbul, Turkey (Türkiye)
Actively Recruiting
106
Cerrahpasa Medical School Istanbul University
Istanbul, Turkey (Türkiye)
Actively Recruiting
107
Marmara University, Research And Education Hospital
Istanbul, Turkey (Türkiye)
Actively Recruiting
108
Dokuz Eylul University School of Medicine
Izmir, Turkey (Türkiye)
Actively Recruiting
109
Manisa Celal Bayar University
Manisa, Turkey (Türkiye)
Actively Recruiting
110
Sakarya University
Sakarya, Turkey (Türkiye)
Actively Recruiting
111
Sivas Cumhuriyet University
Sivas, Turkey (Türkiye)
Actively Recruiting
112
I. Horbachevsky Ternopil National Medical University - Ternopil Regional Children's Hospital
Ternopil, Ukraine
Actively Recruiting
Research Team
L
Luca Cantarini, MD,PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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