Study of the Natural History and Genetics of Systemic Juvenile Idiopathic Arthritis, Adult-Onset Stills Disease, and Related Inflammatory Conditions

What this Trial Is About

Researchers are studying systemic juvenile idiopathic arthritis sJIA, adult-onset Stills disease AOSD, and related inflammatory conditions to understand their natural history, genetics, and underlying biological mechanisms. These diseases often cause symptoms like fevers, arthritis, and rash, with significant variability in severity and response to treatment. The causes of sJIA and AOSD are not well understood, and there are no specific diagnostic tests or biomarkers. The study aims to collect detailed clinical information and biological samples to identify genetic factors and develop a molecular library for future research. Participants include children and adults with known or suspected sJIA, AOSD, or similar inflammatory conditions, as well as their family members and healthy volunteers. The study involves one visit that may last up to five days and can be outpatient or inpatient. During this visit, participants undergo medical history review, physical and musculoskeletal exams, questionnaires about health and quality of life, and may have skin, joint, or spine photos taken. Additional procedures may include blood, urine, stool tests, imaging of joints and chest, heart tests, skin biopsy, joint fluid aspiration, or bone marrow biopsy. Family members and healthy volunteers may provide blood or saliva for genetic testing. Participants may be followed over time with some tests repeated every six months. Assessments include genetic sequencing and comprehensive clinical evaluations. The study is observational, and participants may be seen by specialists. The research collects data and samples to better understand these diseases and identify new treatment targets. The total duration of participation varies depending on follow-up testing needs.

Natural History, Genetics, and Pathophysiology of Systemic Juvenile Idiopathic Arthritis, Adult-Onset Still's Disease, and Related Conditions