Investigation of the Natural History, Genetics, and Pathophysiology of Systemic Juvenile Idiopathic Arthritis, Adult-Onset Still's Disease and Related Inflammatory Conditions

What this Trial Is About

Researchers are investigating systemic juvenile idiopathic arthritis (sJIA), adult-onset Still's disease (AOSD), and related inflammatory conditions to better understand their causes and progression. These conditions cause symptoms like fever, arthritis, and rash, but their origins are unknown. The study focuses on genetics, environmental factors, and the natural history of these diseases, aiming to develop a detailed clinical and molecular understanding over time. Participants include children and adults with known or suspected sJIA, AOSD, or similar inflammatory symptoms, as well as family members and healthy volunteers. The study involves one visit that can last up to five days, including medical history, physical and musculoskeletal exams, and various tests such as blood, urine, stool samples, imaging, skin biopsies, and joint fluid or bone marrow samples when applicable. Some participants may be seen by specialists, and family members may provide genetic samples. During the study, participants complete questionnaires on health, disease activity, and quality of life. Tests may be repeated every six months to monitor changes. Researchers will perform genetic sequencing and collect biological samples to study the diseases' causes and progression. The study includes ongoing safety and follow-up evaluations, with data collected to identify new treatment targets and improve understanding of these inflammatory conditions.

Natural History, Genetics, and Pathophysiology of Systemic Juvenile Idiopathic Arthritis, Adult-Onset Still's Disease, and Related Conditions