Actively Recruiting
Natural History, Genetics, and Pathophysiology of Systemic Juvenile Idiopathic Arthritis, Adult-Onset Still's Disease, and Related Conditions
Led by National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) · Updated on 2026-04-13
2000
Participants Needed
1
Research Sites
1649 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Background: Inflammatory conditions can cause symptoms like fevers, arthritis, and rash. Systemic juvenile idiopathic arthritis (sJIA) is one of these conditions. So is adult-onset Still s disease (AOSD). Their causes are unknown. Researchers want to learn more about these conditions. This includes genetic changes and environmental factors. Objective: To study sJIA and AOSD in children and adults over time. Eligibility: People with known or suspected sJIA, AOSD, or similar inflammatory condition Design: Participants will be screened with a phone call. Participants will have 1 visit. It may be outpatient or they may be admitted to the clinic. The visit may last up to 5 days. Participants will have: * Medical history * Physical exam * Musculoskeletal exam * Questions about overall health and quality of life, disease activity, functional status, and cognitive ability. Participants may also have: * Pictures taken of their skin, joints, or spine * Blood, urine, and stool tests * Scans or X-rays of joints with arthritis * Chest X-ray * Heart tests * Skin biopsy. The skin will be numbed. The top layers of a small area will be scraped off. Participants who have a joint aspiration may provide a fluid sample. The joint will be prepared, then fluid is removed by needle. A corticosteroid may be injected. Participants who have a bone marrow biopsy may provide sample cells. Participants may be seen by NIH specialists. Members of the participant s family and healthy volunteers may give blood or saliva samples for genetic testing. Participants may repeat some study tests every 6 months.
CONDITIONS
Official Title
Natural History, Genetics, and Pathophysiology of Systemic Juvenile Idiopathic Arthritis, Adult-Onset Still's Disease, and Related Conditions
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Known or suspected systemic juvenile idiopathic arthritis (sJIA), adult-onset Still's disease (AOSD), or similar inflammatory condition
- For sJIA: patients under 16 years meeting ILAR criteria or 16 years and older who previously met ILAR criteria
- For AOSD: patients 16 years and older meeting Yamaguchi criteria or with past diagnosis
- Family members of patients included under the above criteria
- Controls for clinical and genetic testing who are not pregnant
- Ability to provide informed consent or have a legal guardian provide consent
You will not qualify if you...
- Adults unable to provide informed consent and without a legally authorized representative
- Minors without a parent or guardian to provide consent
- Any medical condition that may confuse study interpretation
- Inability or unwillingness to follow up with study visits
- Pregnancy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892
Actively Recruiting
Research Team
M
Michelle R Millwood
CONTACT
M
Michael J Ombrello, M.D.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
5
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