Comparing NeutrophilLymphocyte and LactateAlbumin Ratios to Predict Sepsis Outcomes in ICU Patients With Lower Respiratory Infections

What this Trial Is About

This research aims to evaluate and compare the ability of two blood test ratios, the NeutrophilLymphocyte ratio NLR and the LactateAlbumin ratio LA ratio, to predict outcomes in patients with sepsis and septic shock caused by lower respiratory tract infections. Sepsis is a serious condition where the bodys response to infection causes organ dysfunction and can be life-threatening, especially in intensive care settings. The study focuses on understanding which ratio better predicts patient prognosis and mortality. Participants admitted to the intensive care unit with sepsis related to lower respiratory infections will undergo clinical assessments and laboratory tests. Data collected include demographics, vital signs, medication use, mental status, and organ function scores. Blood tests will measure neutrophils, lymphocytes, serum albumin, lactate, and other markers. Various body fluid cultures will be taken to identify infection sources. All tests are performed at a central lab. During the study, researchers will track patient outcomes such as mortality, length of ICU stay, use of vasoactive medications, and support therapies like mechanical ventilation or renal replacement. The main outcomes are mortality and the prognostic value of the two blood test ratios measured from ICU admission until discharge or death. The study will last 12 to 18 months, with careful monitoring to understand how these ratios relate to patient survival and recovery.

A Comparative Study Between Neutrophil/Lymphocyte Ratio and Lactate/Albumin Ratio as Predictive Inflammatory Markers for Sepsis