Study Comparing Adaptive and Continuous Deep Brain Stimulation for Parkinsons Disease Using the Medtronic Percept Device

What this Trial Is About

Researchers are comparing two types of deep brain stimulation DBS treatments, adaptive DBS aDBS and continuous DBS cDBS, in people with Parkinsons disease. The main goal is to see if aDBS increases the daily average time patients spend in an ON state without troublesome involuntary movements more than cDBS over six months. This study involves patients who already have Medtronic Percept DBS electrodes implanted targeting specific brain areas. Participants will first have their devices set to continuous DBS during an initial programming visit. Two weeks later, they will be randomly assigned to either continue with cDBS or switch to aDBS, where the device adapts stimulation based on brain signals. The study follows participants for six months, with check-ins at three and six months. Throughout the study, participants will complete Parkinsons disease home diaries at several time points to track symptoms. During the study, researchers will monitor changes using the home diary from baseline through six months. Other assessments include motor function scales MDS-UPDRS III and IV, cognitive tests, mood and sleep questionnaires, medication use, and brain signal measurements. Safety and side effects will also be tracked. Participants will be evaluated on treatment burden and satisfaction after six months. Overall participation lasts about six months after device programming.

Adaptive vs. Continuous Subthalamic Nucleus Deep Brain Stimulation in Parkinson's Disease