Actively Recruiting
Adaptive vs. Continuous Subthalamic Nucleus Deep Brain Stimulation in Parkinson's Disease
Led by Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Updated on 2026-01-29
130
Participants Needed
4
Research Sites
52 weeks
Total Duration
On this page
Sponsors
A
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Lead Sponsor
H
HagaZiekenhuis
Collaborating Sponsor
AI-Summary
What this Trial Is About
The objective of the CLOSE-PD study is to compare the efficacy of adaptive deep brain stimulation (aDBS) with continue deep brain stimulation (cDBS) in patients with Parkinson's disease. The main question it aims to answer is: \- whether the change in daily mean ON time without troublesome dyskinesia in aDBS is greater than cDBS over a six-month follow-up period? Researchers will compare aDBS to regular continue deep brain stimulation (cDBS). Participants will: * be set up to cDBS during the first programming visit (visit 2); * be randomized 1:1 to aDBS or cDBS two weeks after visit 2; * follow-up will be at three and six months after visit 2; * complete PD Home diary at baseline, two weeks, three months and at six months after visit 2.
CONDITIONS
Official Title
Adaptive vs. Continuous Subthalamic Nucleus Deep Brain Stimulation in Parkinson's Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of idiopathic Parkinson's disease based on UK Brain Bank criteria
- Age older than 18 years
- Previous bilateral implantation of Medtronic Percept PC/RC DBS electrodes targeting the subthalamic nucleus
- At least one optimal contact point compatible with adaptive DBS in one subthalamic nucleus
- Presence of a reliable beta peak in at least one subthalamic nucleus
- Ability to provide informed consent and follow the study protocol
- Understanding of the Dutch language
You will not qualify if you...
- Legally incompetent adults
- Current participation in other clinical trials involving neurological interventions
- Inability to distinguish between motor ON and OFF states
- Mild cognitive impairment or dementia
- Pregnancy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 4 locations
1
UZ Leuven
Leuven, Belgium
Not Yet Recruiting
2
Amsterdam UMC
Amsterdam, Netherlands
Actively Recruiting
3
Maastricht UMC+
Maastricht, Netherlands
Not Yet Recruiting
4
HagaZiekenhuis
The Hague, Netherlands
Not Yet Recruiting
Research Team
M
M. Beudel, MD, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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