Actively Recruiting
Comparison of the Efficacy of Adrenaline and Dopamine in Treating Fluid Refractory Septic Shock in Children
Led by Laiba Qamar · Updated on 2025-12-09
90
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating the effectiveness of two drugs, adrenaline and dopamine, for treating fluid refractory septic shock in children. This serious condition requires urgent treatment, and the study aims to compare how well these drugs work by measuring heart rate, Glasgow Coma Scale (GCS), capillary refill time, peripheral pulse, urine output, and systolic blood pressure. This randomized control trial focuses on children diagnosed with this type of septic shock to determine which drug better corrects these vital parameters over time. Participants will be randomly assigned to receive either adrenaline at a dose of 0.1-0.3 micrograms per kilogram per minute or dopamine at a dose of 10-20 micrograms per kilogram per minute once diagnosed with fluid refractory septic shock. These drugs will be administered continuously during the trial period, and the treatment groups include Group A (adrenaline) and Group B (dopamine). The study does not involve any masking or blinding, and treatments are given based on random assignment. During the study, researchers will monitor participants closely for changes in blood pressure, pulse, capillary refill time, urine output, and GCS over a 6-hour period. Additional assessments include the Sequential Organ Failure Assessment (SOFA) score at 6 hours to evaluate organ function. The trial will enroll children aged 1 month to 12 years, and their vital signs and clinical status will be tracked to compare the effects of the two drugs. The participation duration covers the critical early hours of treatment when fluid refractory septic shock is addressed.
CONDITIONS
Brief Title
Adrenaline V/s Dopamine in Fuid Refractory Septic Shock
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients of both genders aged between 1 month and 12 years
- Diagnosis of fluid refractory septic shock as per operational definition
You will not qualify if you...
- Patients who had cardiopulmonary bypass surgery in the last 5 days
- Patients with chronic systemic diseases such as chronic kidney disease, cerebral palsy, or congenital heart disease
- Patients with neuromuscular disorders
- Patients with metabolic disorders
- Patients previously treated for hypovolemia at another center without medication records or presenting with sequential organ failure
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - Up to 6 hours
Participants receive either adrenaline or dopamine medication to treat fluid refractory septic shock.
1 treatment period with monitoring over 6 hours
Trial Site Locations
Total: 1 location
1
The Children Hospital and The Institute of Child Health Faisalabad
Faisalābad, Punjab Province, Pakistan, 38000
Actively Recruiting
Research Team
H
Hafiz Muhammad Abdullah Dr, MBBS
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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