Actively Recruiting
Brain Network-based Precision Medicine to Predict Dissatisfaction Following Total Knee Arthroplasty
Led by Ottawa Hospital Research Institute · Updated on 2026-03-11
50
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Knee replacement surgery is commonly used to relieve pain and improve mobility in patients with knee osteoarthritis and related conditions. However, up to 20% of patients remain dissatisfied after surgery due to ongoing pain or difficulty with daily activities, and currently, it is difficult for clinicians to predict these outcomes. This research aims to study patterns of brain activity using brain MRI scans to help predict patient satisfaction after total knee arthroplasty (TKA). Participants will undergo a functional MRI (fMRI) brain scan before surgery to measure resting-state brain connectivity. The MRI scan will be repeated approximately two months after surgery to observe changes in brain networks. This study focuses on linking brain network changes to patient-reported pain and function to identify brain-based markers that may predict satisfaction after knee replacement. During the study, researchers will collect patient-reported outcomes using tools such as the Patient-Reported Outcomes Measurement Information System (PROMIS) and the Oxford Knee Score (OKS) before surgery. Brain connectivity will be evaluated preoperatively and again up to 12 months postoperatively to assess changes. The study will measure how brain network patterns relate to postoperative satisfaction and monitor participants over a year. Participation involves MRI scans and completing questionnaires to help researchers understand the relationship between brain activity and recovery after knee replacement.
CONDITIONS
Brief Title
Advanced Brain Imaging-TKA (fMRI-TKA)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male and female patients aged 18 years or older
- Scheduled for primary total knee arthroplasty (TKA)
- Diagnosed with osteoarthritis, inflammatory arthritis, or osteonecrosis
You will not qualify if you...
- Unable or unwilling to sign informed consent
- Non-English or French speaking without available translator or substitute decision maker
- History of major neurological disorders such as traumatic brain injury, epilepsy, or multiple sclerosis
- Cognitive impairment or dementia
- Undergoing revision or bilateral total knee arthroplasty
- Chronic opioid use
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - From preoperative baseline to 12 months post-operative
Participants undergo a total knee arthroplasty and have brain MRI scans to evaluate brain network connectivity.
1 preoperative MRI scan and 1 MRI scan 2 months after surgery
Trial Site Locations
Total: 1 location
1
The Ottawa Hospital
Ottawa, Ontario, Canada
Actively Recruiting
Research Team
S
Sanjula Costa
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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