Actively Recruiting
Advanced Brain Imaging-TKA (fMRI-TKA)
Led by Ottawa Hospital Research Institute · Updated on 2026-03-11
50
Participants Needed
1
Research Sites
143 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Knee replacement surgery is a common and effective treatment for pain and mobility loss, yet up to 1 in 5 patients remain dissatisfied after surgery due to ongoing pain or difficulty with daily activities. Currently, clinicians cannot reliably predict which patients will experience these challenges. This study uses MRI scan of the brain to investigate whether specific patterns of brain activity can predict patient satisfaction after total knee arthroplasty (TKA). By comparing brain networks before surgery and afterward, and linking these changes to patient-reported pain and function, we aim to identify brain-based markers that can help predict outcomes, to improve satisfaction after knee replacement surgery.
CONDITIONS
Official Title
Advanced Brain Imaging-TKA (fMRI-TKA)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male and female patients aged 18 years or older
- Patients scheduled for their first total knee arthroplasty (primary TKA)
- Diagnosis of osteoarthritis, inflammatory arthritis, or osteonecrosis
You will not qualify if you...
- Unable or unwilling to sign informed consent
- Non-English or French speaking without an available translator or substitute decision maker
- History of major neurological disorders such as traumatic brain injury, epilepsy, or multiple sclerosis
- Cognitive impairment or dementia
- Prior revision or bilateral total knee arthroplasty
- Chronic opioid use
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
The Ottawa Hospital
Ottawa, Ontario, Canada
Actively Recruiting
Research Team
S
Sanjula Costa
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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