Using Brain MRI to Predict Satisfaction After Total Knee Replacement Surgery in Adults

What this Trial Is About

Knee replacement surgery is commonly used to relieve pain and improve mobility in patients with knee osteoarthritis and related conditions. However, up to 20% of patients remain dissatisfied after surgery due to ongoing pain or difficulty with daily activities, and currently, it is difficult for clinicians to predict these outcomes. This research aims to study patterns of brain activity using brain MRI scans to help predict patient satisfaction after total knee arthroplasty TKA. Participants will undergo a functional MRI fMRI brain scan before surgery to measure resting-state brain connectivity. The MRI scan will be repeated approximately two months after surgery to observe changes in brain networks. This study focuses on linking brain network changes to patient-reported pain and function to identify brain-based markers that may predict satisfaction after knee replacement. During the study, researchers will collect patient-reported outcomes using tools such as the Patient-Reported Outcomes Measurement Information System PROMIS and the Oxford Knee Score OKS before surgery. Brain connectivity will be evaluated preoperatively and again up to 12 months postoperatively to assess changes. The study will measure how brain network patterns relate to postoperative satisfaction and monitor participants over a year. Participation involves MRI scans and completing questionnaires to help researchers understand the relationship between brain activity and recovery after knee replacement.

Advanced Brain Imaging-TKA (fMRI-TKA)