Actively Recruiting
Age-related Conditions in the Context of Multimorbidity and Frailty: Relative Weight of Frailty in Determining the Course and Outcomes of Different Chronic Diseases and Viceversa
Led by IRCCS San Raffaele · Updated on 2025-06-22
500
Participants Needed
1
Research Sites
8 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are conducting an observational study to assess how frailty and sarcopenia develop over time and to identify related biomarkers. This study involves participants from the earlier FRASNET study as well as patients with mild cognitive impairment and dementia who are being followed at the Neurologic Unit of the San Raffaele Hospital. The aim is to better understand the role of frailty in the progression and outcomes of various chronic diseases. Participants include older volunteers who were previously classified as robust or frail, and patients with cognitive impairments. The study involves comprehensive evaluations including completing scales and questionnaires, venous blood sampling, muscle and cardiac ultrasounds, electrocardiograms, and bioelectrical impedance analysis. These assessments are performed during multidimensional visits to gather detailed clinical and diagnostic data. During the study, participants will undergo these evaluations to monitor frailty, sarcopenia, and cognitive impairment markers. Researchers aim to identify new molecular markers of frailty and sarcopenia by February 2026 and assess how these markers relate to cognitive decline by April 2026. The study is sponsored by IRCCS San Raffaele and will follow participants from March 2024 until April 2026.
CONDITIONS
Brief Title
Age-related Conditions in the Context of Multimorbidity and Frailty: Relative Weight of Frailty in Determining the Course and Outcomes of Different Chronic Diseases and Viceversa
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Having participated in the FRASNET study or being a patient with mild cognitive impairment or dementia followed up at the Neurologic Unit of the San Raffaele Hospital
- Ability to sign written informed consent
- Older than 18 years
You will not qualify if you...
- Life expectancy less than 6 months
- Unwillingness to participate in the study
- Unstable clinical disease such as serious acute pathologies
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 4 years until study completion in April 2026
Participants complete scales and questionnaires and undergo venous blood sampling, muscle ultrasound, cardiac ultrasound, electrocardiogram, and bioelectrical impedance analysis as part of a multidimensional geriatric evaluation.
1 visit (in-person)
Trial Site Locations
Total: 1 location
1
San Raffaele Hospital
Milan, Italy
Actively Recruiting
Research Team
P
Patrizia Rovere Querini, PhD, MD
S
Sarah Damanti, PhD, MD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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